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3.4.24.34: neutrophil collagenase

This is an abbreviated version!
For detailed information about neutrophil collagenase, go to the full flat file.

Word Map on EC 3.4.24.34

Reaction

Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen additional information slowly than type I =

Synonyms

collagenase-2, collagenases-8, EC 3.4.24.7, HNC, human neutrophil collagenase, matrix metalloproteinase, Matrix metalloproteinase 8, Matrix metalloproteinase-8, metalloproteinase-8, MetMMP-8, MMP-7, MMP-8, MMP8, neutrophil collagenase, neutrophil collagenase MMP-8, neutrophil interstitial collagenase, PheMMP-8, PMNL collagenase, PMNL-CL, polymorphonuclear leukocyte collagenase, whMMP-8

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.34 neutrophil collagenase

Expression

Expression on EC 3.4.24.34 - neutrophil collagenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
dexamethasone (Dex) significantly increases MMP-8 mRNA transcripts in a concomitant dry eye and corneal alkali burn murine model
ibuprofen upregulates expressions of matrix metalloproteinase-8, as well as MMP-1, MMP-9, and MMP-13, without affecting expressions of types I and III collagen in tendon cells
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MMP-7 is upregulated after stroke in brain in the infarcted tissue compared to healthy control areas, overview
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MMP8 expression is upregulated in the activated microglia of M/R-challenged brains
MMP8 is induced during intestinal injury
the amount of plasma MMP-8 is increased by whole pelvic irradiation (2.8fold by 0.5 Gy and 5.3fold by 2 Gy) in comparison with controls
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