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3.4.24.34: neutrophil collagenase

This is an abbreviated version!
For detailed information about neutrophil collagenase, go to the full flat file.

Word Map on EC 3.4.24.34

Reaction

Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen additional information slowly than type I =

Synonyms

collagenase-2, collagenases-8, EC 3.4.24.7, HNC, human neutrophil collagenase, matrix metalloproteinase, Matrix metalloproteinase 8, Matrix metalloproteinase-8, metalloproteinase-8, MetMMP-8, MMP-7, MMP-8, MMP8, neutrophil collagenase, neutrophil collagenase MMP-8, neutrophil interstitial collagenase, PheMMP-8, PMNL collagenase, PMNL-CL, polymorphonuclear leukocyte collagenase, whMMP-8

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.34 neutrophil collagenase

KM Value

KM Value on EC 3.4.24.34 - neutrophil collagenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0279 - 0.0622
(7-methoxycoumarin-4-yl)acetyl-Pro-cyclohexylalanine-Gly-norvaline-His-Ala-Arg-NH2
0.0184
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-diaminipropionyl-Ala-Arg-NH2
-
pH 7.0, 37°C, 1-protonated and 2-protonated substrate
-
0.0265 - 0.046
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-diaminopropionyl-Ala-Arg-NH2
0.0208
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-DIAMIONOPROPIONYL-Ala-Arg-NH2
-
pH 7.0, 37°C, unprotonated substrate
0.0194 - 0.0465
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-L-diaminopropionyl-Ala-Arg-NH2
0.000208 - 14.4
bovine collagen I
0.0006
guinea pig collagen type I
-
37°C
-
0.0007
human collagen type I
-
37°C
-
0.0011
human collagen type II
-
37°C
-
0.0018
human collagen type III
-
37°C
-