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analysis
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method to localize enzyme activity within tissues by selective degradation of crosslinked carboxymethylated transferrin on polyethylene films
analysis
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use of substrate PB-M7vis as a proteolytic beacon and optical molecular imaging contrast reagent for in vivo detection of enzyme activity
diagnostics
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associated expression of metalloproteinase-1, metalloproteinase-7 and VEGF in colorectal adenocarcinoma is related to the incidence of disease recurrence
diagnostics
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clinical utility of circulating MMP-7, CC chemokine ligand 18, and CC chemokine ligand 11 as markers for diagnosis of epithelial ovarian cancer, detection method validation, overview
diagnostics
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elevated MMP-7 levels correlate with lymph node invasion and can be predictive for a shorter survival of cancer patients of 2-5 years, elevations of MMP-7 serum levels in the Helicobacter pylori-infected gastric cancer patients can serve as potential biomarker to correlate with poor survival
diagnostics
endometase is putative early biomarker for human carcinomas
diagnostics
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high MMP-7 expression is associated with a worse overall survival of patients with acinic cell carcinoma, while low MMP-7 expression is associated with worse disease-specific survival of patients with acinic cell carcinoma
diagnostics
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MMP-7 immunohistochemistry may be a valuable aid for identification of the cell proliferation center in oral carcinoma in situ and dysplasia
diagnostics
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MMP-7 is a potential biomarker of intrinsic cisplatin sensitivity, ICS, which cisplatin treatment outcome in cancer therapy for advanced head and neck squamous cell carcinomas, overview
diagnostics
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MMP-7 overexpression is an independent prognostic marker in gastric cancer
diagnostics
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preoperative circulating MMP-7 levels in serum samples of patients with clinically localized prostate cancer have prognostic value, elevated serum matrix metalloproteinase 7 levels predict poor prognosis after radical prostatectomy, overview
diagnostics
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the serum MMP-7 can be a diagnostic marker for cholangiocarcinoma, since its level is significantly higher in the patients with cholangiocarcinoma compared to benign biliary tract disease patients. The detection of the serum MMP-7 level is reasonably accurate in differentiating cholangiocarcinoma from benign biliary tract disease patients
diagnostics
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usefulness of the combination of fecal cyclooxygenase 2, COX-2, mRNA and MMP-7 mRNA assays as a marker of colorectal cancer, evaluation of the feces screening method, overview
diagnostics
matrix metalloproteinase 7 is a useful marker for 5-fluorouracil-based adjuvant chemotherapy in stage II and stage III colorectal cancer patients
diagnostics
the enzyme is a potential marker for diagnosis of colorectal cancer
diagnostics
the enzyme MMP-7 may be a prognostic factor for disease-free survival in men with rectal cancer without distant metastasis
diagnostics
matrix metalloproteinase-7 (MMP-7) is an early and valuable biomarker for predicting severe acute kidney injury (AKI) and poor outcomes in patients after cardiac surgery
drug development
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andrographolide is a chemotherapeutic agent due to its ability of inhibiting tumor cell proliferation and inflammation by e.g. supprressing MMP-7
drug development
matrilysin is an ideal biological target to developl inhibitors because it is overexpressed in malignant tumour cells
medicine
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developing and searching for effective inhibitors of matrilysin for cancer diagnosis and therapy
medicine
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development of effective inhibitors useful for cancer therapy
medicine
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matrilysin is overexpressed in cancer cells of variuos organs including prostate, colorectum, brain, and stomach, important role in tumor invasion and metastasis
medicine
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enzyme is involved in cell dissociation and the subsequent invasion of pancreatic cancer cells. It induces the disruption of tight junction structure and forms a positive feedback loop with activation of the epidermal growth factor receptor mediated MEK-ERK signalling pathway
medicine
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overexpression of enzyme correlates with breast cancer in vitro invasiveness, enzyme may promote invasion by increasing the secretion and activation of matrix metalloproteinases proMMP-2 and pro-MMP-9
medicine
MMP-7 promotes tolerance of incompatibel allografts and may help in development of strategies to improve long-term graft outcome in transplantation
medicine
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among patients with pT3 rectosigmoid cancer, fortyfive percent of the rectosigmoid cancers show strong expression of MMP-7. Membranous or cytoplasmic beta-catenin expression is significantly related to E-cadherin and MMP-7 expression. No significant association is seen between E-cadherin, beta-catenin, or MMP-7 expression and some clinicopathologic features
medicine
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induction of specific natural killer cells using monocyte-derived dendritic cells electroporated with MMP-7-mRNA. The induced CTLs elicit an antigen-specific and HLA-restricted cytolytic activity against tumor cells endogenously expressing the MMP-7 protein. MMP-7-specific natural killer cells could be induced using peripheral blood mononuclear cells from a patient with acute lymphoblastic leukemia capable of recognizing the autologous leukemic blasts while sparing nonmalignant cells
medicine
MMP-7 genetic polymorphisms are significant determinants of survival among Chinese women with breast cancer
medicine
serum matrilysin level predicts recurrence in curatively resected colorectal cancer patients. Patients with matrilysin level higher than the median 4.3 ng/ml are more likely to relapse. Median time to progression in relapsed patients is 8 months if matrilysin is above 4.3 ng/ml and 18 months if matrilysin is below 4.3 ng/ml. Node-negative patients with low matrilysin level have a predicted probability of relapse-free survival at 4 years of 88%; if the matrilysin level is higher than the median value, this probability is 77%
pharmacology
MMP-7 is an important target for antimetastasis therapy of colorectal cancer because it is a strong proteolytic factor secreted from the cancer cell itself and it induces tumor angiogenesis
pharmacology
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in sulindac-treated ApcMin/+ mice, a genetic model of human familial adenomatous polyposis, collagen genes, viz. Col1a2, Col5a2, Col6a2, and Col6a3, are upregulated, and matrilysin matrix metalloproteases-7 is downregulated. Mmp7 is found in hot spot areas within the tumors of ApcMin/+ mice treated with the vehicle, but is greatly diminished in those mice treated with sulindac