3.4.24.23: matrilysin
This is an abbreviated version!
For detailed information about matrilysin, go to the full flat file.
Word Map on EC 3.4.24.23
-
3.4.24.23
-
metalloproteinases
-
mmp-2
-
metastasis
-
timp-1
-
colorectal
-
fibrosis
-
collagen
-
endothelial
-
node
-
gelatinase
-
e-cadherin
-
clinicopathological
-
zymography
-
interstitial
-
gastric
-
epithelium
-
tumour
-
adenocarcinoma
-
pulmonary
-
basement
-
prostate
-
invasiveness
-
tumorigenesis
-
beta-catenin
-
gelatin
-
carcinogenesis
-
resect
-
mt1-mmp
-
cyclin
-
c-myc
-
adenoma
-
plasminogen
-
transwell
-
osteopontin
-
metalloelastase
-
stromelysin-1
-
laminin-5
-
hemopexin-like
-
pharmacology
-
upa
-
drug development
-
alpha-defensins
-
collagenase-3
-
analysis
-
medicine
-
diagnostics
-
gelatinolytic
-
matrix-degrading
-
paneth
-
membrane-type
- 3.4.24.23
- metalloproteinases
- mmp-2
- metastasis
- timp-1
- colorectal
- fibrosis
- collagen
- endothelial
- node
- gelatinase
- e-cadherin
-
clinicopathological
-
zymography
-
interstitial
- gastric
- epithelium
- tumour
- adenocarcinoma
- pulmonary
-
basement
- prostate
-
invasiveness
- tumorigenesis
- beta-catenin
- gelatin
- carcinogenesis
-
resect
- mt1-mmp
- cyclin
- c-myc
- adenoma
- plasminogen
-
transwell
- osteopontin
- metalloelastase
- stromelysin-1
- laminin-5
-
hemopexin-like
- pharmacology
- upa
- drug development
- alpha-defensins
- collagenase-3
- analysis
- medicine
- diagnostics
-
gelatinolytic
-
matrix-degrading
-
paneth
-
membrane-type
Reaction
Cleavage of Ala14-/-Leu and Tyr16-/-Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I) =
Synonyms
cyclic matrix metalloproteinase, human matrix metalloproteinase 7, matrilysin, matrilysin 1, matrilysin-1, Matrin, matrix metallopeptidase 7, matrix metalloprotease-7, Matrix metalloproteinase 7, Matrix metalloproteinase pump 1, Matrix metalloproteinase-7, matrix-metalloproteinase-7, metalloproteinase-7, MMP, MMP 7, MMP-7, MMP7, More, Proteinase, metallo-, pump-1, Proteinase, PUMP-1, PUMP, PUMP-1, Pump-1 protease, Putative (or punctuated) metalloproteinase-1, Putative metalloproteinase, Uterine metalloendopeptidase, Uterine metalloproteinase
ECTree
3.4.24.23 matrilysinAdvanced search results
results (
results (Engineering
Engineering on EC 3.4.24.23 - matrilysin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
G137D
-
a naturally occuring polymorphism, the Asp137 genetic variant of MMP-7 is susceptible to liver cirrhosis, MMP-7 D137 shows an increased level in its distribution to the plasma membrane of HSCs and an enhanced ability on cell migration, overview. It converts to its active form in specific microdomains
Y193F
-
site-directed mutagenesis, the mutant shows no pH-dependence shift, as does mutants Y219X
Y216F
-
site-directed mutagenesis, the mutant shows no pH-dependence shift, as does mutants Y219X
Y219A
-
site-directed mutagenesis, the mutant variant retains its catalytic activity, but exhibits narrower pH-dependence than the wild-type MMP-7
Y219C
-
site-directed mutagenesis, the mutant variant retains its catalytic activity, but exhibits narrower pH-dependence than the wild-type MMP-7
Y219D
-
site-directed mutagenesis, the mutant variant retains its catalytic activity, but exhibits narrower pH-dependence than the wild-type MMP-7
Y219F
-
site-directed mutagenesis, the mutant variant retains its catalytic activity, but exhibits narrower pH-dependence than the wild-type MMP-7
Y219S
-
site-directed mutagenesis, the mutant variant retains its catalytic activity, but exhibits narrower pH-dependence than the wild-type MMP-7
additional information
additional information
-
induction of specific natural killer cells using monocyte-derived dendritic cells electroporated with MMP-7-mRNA. The induced CTLs elicit an antigen-specific and HLA-restricted cytolytic activity against tumor cells endogenously expressing the MMP-7 protein. MMP-7-specific natural killer cells could be induced using peripheral blood mononuclear cells from a patient with acute lymphoblastic leukemia capable of recognizing the autologous leukemic blasts while sparing nonmalignant cells
additional information
-
a form of MMP-7 containing an Glu to Gln mutation in the catalytic domain is catalytically inactive
additional information
-
allergen-challenged Mmp7-/- mice show less airway hyperreactivity and production of allergic inflammatory cytokines and higher expression of retinal dehydrogenase 1. Inhibition of retinal dehydrogenase 1 restores the asthma phenotype of Mmp7-/- mice and inhibits the responses of lung regulatory T cells, whereas exogenous administration of retinoic acid attenuates the asthma phenotype, overview
additional information
-
determination of MMP-7 181A/G polymorphisms involved in colorectal cancer, the MMP-3 5A allele is involved in the progression of adenoma to cancer, overview
additional information
-
genotype and allele frequencies of transforming growth factor-B1, TGF-B1, and MMP-7 polymorphisms do not differ between patients with Helicobacter pylori-associated gastric precancerous lesions and control persons, overview. But CagA-positive patients carrying MMP-7 -181 G allele have a risk for lymphoid follicle formation. Thus, the present study reveal significant association of functional MMP-7 and TGF-B1 gene variants toward susceptibility to Helicobacter pylori-induced precancerous gastric lesions
additional information
-
host MMP-7 contributes to mammary tumor growth in the bone microenvironment after injection of human tumor cells into tibias of mice
additional information
-
MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview
additional information
-
MMP-7 polymorphisms increase the risk for endometrial cancer in women over 50. The frequencies of MMP-7 -181 G/G and A/G genotypes are found to be significantly higher in cancer patients compared with healthy controls
additional information
-
MMP-7 tethered to cancer cell surface via cholesterol sulfate degrades fibronectin and laminin-332 coated on a culture plate
additional information
-
overexpression of MMP-7, and knocked-down using small inhibitory RNAs
additional information
-
generation of MMP-7 pro-domain mutants lacking the N-terminal linker of the pro-domain (DELTAN, residues 9-79), the C-terminal linker (DELTAC, residues 1-73), or both (DELTANC, residues 9-73), secondary structure homology modeling analysis. Mutant DELTANC retains the triple alpha-helical structure
additional information
generation of mutant MMP-7(29,33,51,55/M2)DELTAC3, a variant of MMP-7 lacking affinity for cell surface cholesterol sulfate (CS)
additional information
MMP-7 siRNA-mediated knockdown and immunoneutralization of MMP-7 in OE33 cells causes increased migration and invasion in response to conditioned media of myofibroblasts
additional information
construction of MMP-7 knockout mice, which show higher content of pathogens in the small intestine two weeks after vaginal infection with Chlamydia trachomatis mouse pneumonitis as compared to wild-type C57BL/6 mice, because MMP-7 KO mice are deficient in active intestinal alpha-defensins, which play a role in regulating colonization of the gastrointestinal tract by Chlamydia, overview
additional information
-
construction of MMP-7 knockout mice, which show higher content of pathogens in the small intestine two weeks after vaginal infection with Chlamydia trachomatis mouse pneumonitis as compared to wild-type C57BL/6 mice, because MMP-7 KO mice are deficient in active intestinal alpha-defensins, which play a role in regulating colonization of the gastrointestinal tract by Chlamydia, overview
additional information
enzyme-deficient MMP7-/- mice show a lower mortality rate compared to wild-type mice in case of colon mucosal injury and inflammation, while neutrophil influx is similar in both cases, overview
additional information
MMP-7-deficient cells do not show activation of Notch-1, which can be restored by recombinant MMP-7, phenotype, overview
additional information
-
ApcMin/+ Mmp7-/- double-deficient mice demonstrate reciprocal relationships of Mmp7 expression and the levels of the collagens Col1a2, Col5a2, Col6a2, and Col6a3 in vivo
additional information
-
construction of MMP-7 null mice that show lower levels of full-length peroxiredoxin-1 and -2 and higher levels of the full-length peroxiredoxin-3, suggesting MMP-7 deletion may also indirectly regulate protein levels through nonenzymatic mechanisms. Null mice also show reduced fibronectin and tenascin-C fragment generation, which is restored by exogenous administration of MMP-7
additional information
-
introduction of an Mmp7 knockout mutation into the cis-Apc/Smad4 mutant mouse, a model of invasive colon cancer in which SMAD4-dependent TGF-beta family signaling is inactivated. Lack of MMP7 reduces the number and size of tumors in the cis-Apc/Smad4 mice
additional information
-
knockdown of MMP-7 by siRNA attenuates hypertension, inhibits ADAM-12 overexpression, and prevents cardiac hypertrophy. Resistance to acute hypertension in mice lacking active MMP-7
additional information
-
MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview
additional information
-
MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview
-
additional information
-
MMP-7-deficient cells do not show activation of Notch-1, which can be restored by recombinant MMP-7, phenotype, overview
-
additional information
-
construction of MMP-7 knockout mice, which show higher content of pathogens in the small intestine two weeks after vaginal infection with Chlamydia trachomatis mouse pneumonitis as compared to wild-type C57BL/6 mice, because MMP-7 KO mice are deficient in active intestinal alpha-defensins, which play a role in regulating colonization of the gastrointestinal tract by Chlamydia, overview
-
additional information
-
enzyme-deficient MMP7-/- mice show a lower mortality rate compared to wild-type mice in case of colon mucosal injury and inflammation, while neutrophil influx is similar in both cases, overview
-
additional information
-
MMP-7 gene knockout or knockdown of MMP-7 by RNA interference, results in attenuation of hypertension and stops development of cardiac hypertrophy in spontaneously hypertensive rats, and in decreased levels of myocardial ADAM-12 mRNA
