3.4.24.23: matrilysin

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For detailed information about matrilysin, go to the full flat file.

Reaction

Cleavage of Ala14-/-Leu and Tyr16-/-Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I) =

Synonyms

cyclic matrix metalloproteinase, human matrix metalloproteinase 7, matrilysin, matrilysin 1, matrilysin-1, Matrin, matrix metallopeptidase 7, matrix metalloprotease-7, Matrix metalloproteinase 7, Matrix metalloproteinase pump 1, Matrix metalloproteinase-7, matrix-metalloproteinase-7, metalloproteinase-7, MMP, MMP 7, MMP-7, MMP7, More, Proteinase, metallo-, pump-1, Proteinase, PUMP-1, PUMP, PUMP-1, Pump-1 protease, Putative (or punctuated) metalloproteinase-1, Putative metalloproteinase, Uterine metalloendopeptidase, Uterine metalloproteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.23 matrilysin

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Results	in table
17	Activating Compound
13	AA Sequence
31	Application
1	CAS Registry Number
35	Cloned(Commentary)
3	Crystallization (Commentary)
7149	Disease/ Diagnostics
25	Expression
84	General Information
4	IC50 Value
190	Inhibitors
6	kcat/KM [mM/s]
24	Ki Value [mM]
24	KM Value [mM]
62	Localization
50	Metals/Ions
13	Molecular Weight [Da]
79	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
524	Organism
13	PDB ID
24	pH Optimum
5	pH Range
14	Posttranslational Modification
47	Protein Variants
16	Purification (Commentary)
1	Reaction
1	Reaction Type
174	Reference
4	Renatured (Commentary)
272	Source Tissue
3	Specific Activity [micromol/min/mg]
215	Substrates and Products (Substrate)
10	Subunits
252	Synonyms
23	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
21	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.24.23 - matrilysin

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4

Homo sapiens

-

purified mutants are stable at

649827

50 - 60

Homo sapiens

P09237

purified enzyme with or without heparin and cholesterol sulfate, 10 min, 10-40% activity remaining, overview

733534

69 - 76

Homo sapiens

-

50% of the activity is lost upon incubation at 69°C for 10 min, activity decreases to zero as temperature is raised to 76°C

651772

70

Homo sapiens

P09237

purified enzyme, inactivation within 10 min

733534

additional information

2 entries

additional information

Homo sapiens

P09237

in thermal incubation of the enzyme at 50-70°C, heparin increases the relative activity (the ratio of kcat/Km of MMP-7 with incubation to that without it), while cholesterol sulfate decreases the relative activity

733534

additional information

Homo sapiens

-

in thermal incubation of the enzyme at 50-70°C, heparin increases the relative activity (the ratio of kcat/Km of MMP-7 with incubation to that without it), while cholesterol sulfate decreases the relative activity

733534