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3.4.24.23: matrilysin

This is an abbreviated version!
For detailed information about matrilysin, go to the full flat file.

Word Map on EC 3.4.24.23

Reaction

Cleavage of Ala14-/-Leu and Tyr16-/-Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I) =

Synonyms

cyclic matrix metalloproteinase, human matrix metalloproteinase 7, matrilysin, matrilysin 1, matrilysin-1, Matrin, matrix metallopeptidase 7, matrix metalloprotease-7, Matrix metalloproteinase 7, Matrix metalloproteinase pump 1, Matrix metalloproteinase-7, matrix-metalloproteinase-7, metalloproteinase-7, MMP, MMP 7, MMP-7, MMP7, More, Proteinase, metallo-, pump-1, Proteinase, PUMP-1, PUMP, PUMP-1, Pump-1 protease, Putative (or punctuated) metalloproteinase-1, Putative metalloproteinase, Uterine metalloendopeptidase, Uterine metalloproteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.23 matrilysin

Expression

Expression on EC 3.4.24.23 - matrilysin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
1,25-dihydroxyvitamin D3, i.e. 1, 25(OH)2D3, significantly reduces the MMP-7 and MMP-9 and increases the TIMP-1 inhibitor level in Mycobacterium tuberculosis antigen stimulated and unstimulated mononuclear cell cultures of pulmonary tunerculosis patients as compared to healthy persons
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andrographolide diminishes the activity and the mRNA and protein levels of MMP-7, but not MMP-2 or MMP-9. The downregulation of MMP-7 appears to be via the inactivation of activator protein-1, AP-1, overview
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dominant negative insulin-like growth factor-I receptor, i.e. IGF-IR/dn, suppresses MMP-7 expression in invasive subcutaneous tumors. IGF-stimulated secretion of matrilysin and IGF-IR/dn blocks IGF-mediated matrilysin induction in three gastrointestinal cancers, overview
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expression of MMP-7 is downregulated by tamoxifen and 5-fluorouracil in combination in HT-29 cells
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fibulin-5 downregulates MMP-7, suppression of fibulin-5, as well as deletion of its RGD motif, induces MMP-7 expression in lung. Suppression of MMP-7 expression by fibulin-5 is mediated by an integrin-binding RGD motif via the extracellular signal-regulated kinase pathway
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Helicobacter pylori infection upregulates the expression of matrix metalloproteinases, involved in chronic inflammation, ulceration, and cancer development
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Helicobacter pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro
IGF stimulates matrilysin expression in gastrointestinal cancer cell lines
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infection by Mycobacterium tuberculosis upregulates MMP-7 expression
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inhibition of hyaluronan synthases HAS2 and HAS3 highly decreases MMP-7 expression and activity in SW620 cells
lung injury promotes the expression of matrix metalloproteinase-7
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MMP-7 expression is induced in te epidermis by physiological processes such as wound healing, but also malignant transformation of epidermal cells
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MMP7 is upregulated by oxaliplatin in colon cancer cell lines. FasL expression is also upregulated by oxaliplatin treatment but decreased in the plasma membrane of resistant cells
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Mycobacterium tuberculosis infection and its antigen cause an increase in MMP-7 expression in mononuclear cell cultures of pulmonary tunerculosis patients as compared to healthy persons untreated with 1,25-dihydroxyvitamin D3
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no apparent regulation of the expression of MMP-7 by either tumor necrosis factor or enamel matrix derivative
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possibly SFRP5 downregulation upregulates MMP-7 via the noncanonical Wnt pathway, overview
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resveratrol inhibits MMP7 expression
serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction
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syndecan-2 enhances both expression and secretion of MMP-7, directly interacts with pro-MMP-7, and potentiates the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells, overview
the enzyme expression is increased in epithelium by bacterial infection, inflammation, fibrosis, and in a lot of carcinomas
TIMP-1 from gingival and dermal fibroblasts forms complexes with MMP-7 and inhibits its expression and activity. TGF-1beta mediates the secretion of MMP-7, but TGF-1beta inhibits MMP-7 expression. The MMP-7 gene has three TGF-beta1 inhibitory element, TIE, sites
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YAP, EGFR, integrin-alpha2beta1 and MRLC produce a positive feedback loop that enhances MMP-7 expression. Stiff substrates enhance colorectal cancer cell viability by upregulating MMP-7 expression through a positive feedback loop
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yes-associated protein (YAP) knockdown decreases MMP-7 expression. Treatment with inhibitors of epidermal growth factor receptor (EGFR) and myosin regulatory light chain (MRLC) and integrin-alpha2 or integrin-beta1 knockdown downregulate MMP-7 expression
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