Application | Comment | Organism |
---|---|---|
drug development | andrographolide is a chemotherapeutic agent due to its ability of inhibiting tumor cell proliferation and inflammation by e.g. supprressing MMP-7 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
andrographolide | a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, downregulates MMP-7 in colorectal carcinoma LoVo cells leading to inhibition of cell migration and invasion, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloprotease-7 | - |
Homo sapiens |
MMP-7 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | andrographolide diminishes the activity and the mRNA and protein levels of MMP-7, but not MMP-2 or MMP-9. The downregulation of MMP-7 appears to be via the inactivation of activator protein-1, AP-1, overview | down |