Literature summary for 3.4.24.23 extracted from

Jovanovic, V.; Dugast, A.S.; Heslan, J.M.; Ashton-Chess, J.; Giral, M.; Degauque, N.; Moreau, A.; Pallier, A.; Chiffoleau, E.; Lair, D.; Usal, C.; Smit, H.; Vanhove, B.; Soulillou, J.P.; Brouard, S.
Implication of matrix metalloproteinase 7 and the noncanonical wingless-type signaling pathway in a model of kidney allograft tolerance induced by the administration of anti-donor class II antibodies (2008), J. Immunol., 180, 1317-1325.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	enzyme expression is upregulated in kidneys that are MHC-incompatible allografts but are tolerated through induction by the administration of anti-donor class II antibodies, as part of the pivotal non-canonical wingless-type signaling pathway, overview	Rattus norvegicus

Application

Application	Comment	Organism
medicine	MMP-7 promotes tolerance of incompatibel allografts and may help in development of strategies to improve long-term graft outcome in transplantation	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	the enzyme is involved in the pivotal wingless-type signaling pathway and in tolerance of MHC-incompatible allografts, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P50280	LEW.1A and LEW.1W rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	expression analysis in hearts after transplantation, overview	Rattus norvegicus	-
kidney	expression analysis in kidneys after transplantation, overview	Rattus norvegicus	-
vascular smooth muscle cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is involved in the pivotal wingless-type signaling pathway and in tolerance of MHC-incompatible allografts, overview	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
Matrix metalloproteinase 7	-	Rattus norvegicus
MMP7	-	Rattus norvegicus

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Release 2023.1 (January 2023)