3.4.23.B8: human T-cell leukemia virus type 1 protease

This is an abbreviated version!
For detailed information about human T-cell leukemia virus type 1 protease, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

C2A HTLV-1 PR, HTLV-1 PR, HTLV-1 protease, HTLV-I PR, HTLV-I protease, human T cell leukemia virus PR, human T cell leukemia virus protease, human T-cell leukemia virus type 1 protease, human T-lymphotropic virus type I protease, More, retropepsin (human T-cell leukemia virus), simian T-cell leukemia virus endopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B8 human T-cell leukemia virus type 1 protease

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	AA Sequence
4	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Crystallization (Commentary)
6	General Information
68	IC50 Value
164	Inhibitors
11	kcat/KM [mM/s]
39	Ki Value [mM]
61	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
38	Organism
5	pH Optimum
1	pH Range
1	Posttranslational Modification
25	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
2	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
10	Subunits
27	Synonyms
5	Temperature Optimum [°C]
66	Turnover Number [1/s]

KI Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

KI Value on EC 3.4.23.B8 - human T-cell leukemia virus type 1 protease

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Ki Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000306

(2R)-2-[(3-[[(R)-amino(hydroxy)methyl][2-hydroxy-2-(naphthalen-2-yl)ethyl]amino]-3-cyclopentylpropyl)amino]-N-benzyl-2-hydroxyethanesulfonamide

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

0.000202

2-(4-tert-butylphenyl)-N-carbamoyl-N-[3-([[(pyridin-1(2H)-ylmethyl)sulfamoyl]carbonyl]amino)-3-(pyrrolidin-1-yl)propyl]acetamide

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

-

0.0000477

2-(4-tert-butylphenyl)-N-carbamoyl-N-[3-[([[(3,5-dichloro-4-oxopyridin-1(4H)-yl)methyl]sulfamoyl]carbonyl)amino]-3-[3-(hydroxyamino)-4-oxopyrrolidin-1-yl]propyl]acetamide

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

-

0.00008

4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647856

0.00005

Ac-Ala-Pro-Gln-Val-statine-Val-Met-His-Pro

Human T-cell leukemia virus type I

-

recombinant enzyme, pH 5.5, 37°C

670680

0.0506

Ac-Leu-Lys-Ala-Gln-Ile-His-Phe

Human T-cell leukemia virus type I

-

-

647862

0.093

Ac-Leu-Val-Phe-H

Human T-cell leukemia virus type I

-

-

647862

1.7

Ac-Pro-Gln-Ile-Thr-Leu-Trp-Gln-Arg-Pro-NH2

Human T-cell leukemia virus type I

-

-

647862

0.000006

Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester

2 entries

0.252

Ac-Thr-Leu-Asn-Phe

Human T-cell leukemia virus type I

-

-

647862

0.217

Ac-Thr-Val-Ser-Phe-Asn-Phe

Human T-cell leukemia virus type I

-

-

647862

0.00005

Ala-Pro-Gln-Val-statine-Val-Met-His-Pro

2 entries

0.000466

CS-I-51

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

0.07

Gln-Met-Gln-Gly-Val-Leu-Tyr-Leu

Human T-cell leukemia virus type I

-

-

647862

0.00494

H-Pro-Val-Ile-hydroxyethylamine[(R)-isobutyl,(R)-hydroxy]-Pro-NH-CH2-C6H4I

Human T-cell leukemia virus type I

-

-

647853

0.292

H-Pro-Val-Ile-hydroxyethylamine[(R)-isobutyl,(S)-hydroxy]-Pro-NH-CH2-C6H4I

Human T-cell leukemia virus type I

-

-

647853

0.038

H-Pro-Val-Ile-hydroxyethylamine[(S)-isobutyl,(R)-hydroxy]-Pro-NH-CH2-C6H4I

Human T-cell leukemia virus type I

-

-

647853

0.00549

H-Pro-Val-Ile-hydroxyethylamine[(S)-isobutyl,(S)-hydroxy]-Pro-NH-CH2-C6H4I

Human T-cell leukemia virus type I

-

-

647853

0.000142

isobutyl oxycarbonyl-Lys--Val-Val-(3S,4S)-statine-Ala-isoamylamine

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

0.0000072

isovaleryl-Lys-Val-(3S,4S)-statine-Ala-isoamylamine

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

0.000138

isovaleryl-Val-Nle-(3S,4S)-statine-Ala-isoamylamine

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

0.0072

isovaleryl-Val-Val-(3S,4S)-statine-Ala-Lys-methyl ester

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

0.00111

KNI-10673

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

0.00317

KNI-10681

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

0.00197

KNI-10683

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

0.00162

KNI-10729

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

0.0000219

KNI1595b

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

0.00024 - 0.00243

MES13-099

2 entries

0.00000123

N-(3-[[(benzylsulfamoyl)carbonyl]amino]-1-cyclopentylpropyl)-N-carbamoyl-N2-hydroxy-N2-(hydroxymethyl)glycinamide

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

-

0.017 - 0.2

pepstatin A

2 entries

0.000268

phenyl (9S)-5-cyclopentyl-3,6,9-trihydroxy-2-(naphthalen-2-yl)-2,5,8,10-tetraazadodecane-12-sulfonate

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754685

0.0872

Pro-Val-Ile-Pro-Leu-Asp-Pro-Ala-Arg-Arg-Pro-Val

Human T-cell leukemia virus type I

-

-

647862

0.00008

tert-butyloxycarbonyl-Val-Val-Phe[P(O)(OH)-]-Phe-Val-Val-NH2

Human T-cell leukemia virus type I

-

-

647862

0.0008

tetradecahydrophenazine-2,3-diamine

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

733121

0.0057

Tyr-Leu-Pro-Glu-Ala-Lys-Arg-Pro-Pro-Val-Ile-Leu

Human T-cell leukemia virus type I

-

-

647862

0.000006

Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester

Human T-cell leukemia virus type I

-

-

647862

0.000006

Ac-Ser-Leu-Asn-Phe-CH(OH)CH2NH-Pro-Ile-Val-methyl ester

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

0.00005

Ala-Pro-Gln-Val-statine-Val-Met-His-Pro

Human T-cell leukemia virus type I

-

-

647862

0.00005

Ala-Pro-Gln-Val-statine-Val-Met-His-Pro

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647856

0.00024

MES13-099

Human T-cell leukemia virus type I

-

-

647862

0.00243

MES13-099

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

0.017

pepstatin A

Human T-cell leukemia virus type I

-

pH 5.0, 37°C

647849

0.2

pepstatin A

Human T-cell leukemia virus type I

-

-

647858