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3.4.23.B8: human T-cell leukemia virus type 1 protease

This is an abbreviated version!
For detailed information about human T-cell leukemia virus type 1 protease, go to the full flat file.

Word Map on EC 3.4.23.B8

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

C2A HTLV-1 PR, HTLV-1 PR, HTLV-1 protease, HTLV-I PR, HTLV-I protease, human T cell leukemia virus PR, human T cell leukemia virus protease, human T-cell leukemia virus type 1 protease, human T-lymphotropic virus type I protease, More, retropepsin (human T-cell leukemia virus), simian T-cell leukemia virus endopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B8 human T-cell leukemia virus type 1 protease

Reference

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Reference on EC 3.4.23.B8 - human T-cell leukemia virus type 1 protease

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Malik K.T.A.; Even J.; Karpas A.
Molecular cloning and complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate of Caribbean origin: relationship to other members of the ATLV/HTLV-I subgroup
J. Gen. Virol.
69
1695-1710
1988
Human T-cell leukemia virus type I
-
Manually annotated by BRENDA team
Kobayashi, M.; Ohi, Y.; Asano, T.; Hayakawa, T.; Kato, K.; Kakinuma, A.; Hatanaka, M.
Purification and characterization of human T-cell leukemia virus type I protease produced in Escherichia coli
FEBS Lett.
293
106-110
1991
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Llido, S.; Langlois d'Estaintot, B.; Dautant, A.; Geoffre, S.; Picard, P.; Precigoux, G.
Conformational study of a putative HTLV-1 retroviral protease inhibitor
Acta Crystallogr. Sect. D
49
344-348
1993
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Ding, Y.S.; Rich, D.H.; Ikeda, R.A.
Substrates and inhibitors of human T-cell leukemia virus type I protease
Biochemistry
37
17514-17518
1998
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Hayakawa, T.; Misumi, Y.; Kobayashi, M.; Yamamoto, Y.; Fujisawa, Y.
Requirement of N- and C-terminal regions for enzymatic activity of human T-cell leukemia virus type I protease
Eur. J. Biochem.
206
919-925
1992
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Akaji, K.; Teruya, K.; Aimoto, S.
Solid-Phase Synthesis of HTLV-1 Protease Inhibitors Containing Hydroxyethylamine Dipeptide Isostere
J. Org. Chem.
68
4755-4763
2003
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Tözser, J.; Zahuczky, G.; Bagossi, P.; Louis, J.M.; Copeland, T.D.; Oroszlan, S.; Harrison, R.W.; Weber, I.T.
Comparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases
Eur. J. Biochem.
267
6287-6295
2000
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Davis, D.A.; Brown, C.A.; Newcomb, F.M.; Boja, E.S.; Fales, H.M.; Kaufman, J.; Stahl, S.J.; Wingfield, P.; Yarchoan, R.
Reversible oxidative modification as a mechanism for regulating retroviral protease dimerization and activation
J. Virol.
77
3319-3325
2003
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Louis, J.M.; Oroszlan, S.; Tozser, J.
Stabilization from autoproteolysis and kinetic characterization of the human T-cell leukemia virus type 1 proteinase
J. Biol. Chem.
274
6660-6666
1999
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Saiga, A.; Tanaka, T.; Orita, S.; Sato, A.; Sato, S.; Hachisu, T.; Abe, K.; Kimura, Y.; Kondo, Y.; Fujiwara, T.; et al.
Human T-cell leukemia virus type 1 protease protein expressed in Escherichia coli possesses aspartic proteinase activity
Arch. Virol.
128
195-210
1993
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Ding, Y.S.; Owen, S.M.; Lal, R.B.; Ikeda, R.A.
Efficient expression and rapid purification of human T-cell leukemia virus type 1 protease
J. Virol.
72
3383-3386
1998
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Pettit, S.C.; Sanchez, R.; Smith, T.; Wehbie, R.; Derse, D.; Swanstrom, R.
HIV type 1 protease inhibitors fail to inhibit HTLV-I Gag processing in infected cells
AIDS Res. Hum. Retroviruses
14
1007-1014
1998
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Mariani, V.L.; Shuker, S.B.
Identification of the RT-RH/IN cleavage site of HTLV-I
Biochem. Biophys. Res. Commun.
300
268-270
2003
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Ha, J.J.; Gaul, D.A.; Mariani, V.L.; Ding, Y.S.; Ikeda, R.A.; Shuker, S.B.
HTLV-I protease cleavage of P19/24 substrates is not dependent on NaCl concentration
Bioorg. Chem.
30
138-144
2002
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Shuker, S.B.; Mariani, V.L.; Herger, B.E.; Dennison, K.J.
Understanding HTLV-I Protease
Chem. Biol.
10
373-380
2003
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Bagossi, P.; Sperka, T.; Feher, A.; Kadas, J.; Zahuczky, G.; Miklossy, G.; Boross, P.; Toezser, J.
Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites
J. Virol.
79
4213-4218
2005
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Herger, B.E.; Mariani, V.L.; Dennison, K.; Shuker, S.B.
The 10 C-terminal residues of HTLV-I protease are not necessary for enzymatic activity
Biochem. Biophys. Res. Commun.
320
1306-1308
2004
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Alvarez, E.; Castello, A.; Menendez-Arias, L.; Carrasco, L.
HIV protease cleaves poly(A)-binding protein
Biochem. J.
396
219-226
2006
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Kadas, J.; Weber, I.T.; Bagossi, P.; Miklossy, G.; Boross, P.; Oroszlan, S.; Toezser, J.
Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease
J. Biol. Chem.
279
27148-27157
2004
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Li, M.; Laco, G.S.; Jaskolski, M.; Rozycki, J.; Alexandratos, J.; Wlodawer, A.; Gustchina, A.
Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design
Proc. Natl. Acad. Sci. USA
102
18332-18337
2005
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Zhang, M.; Nguyen, J.T.; Kumada, H.O.; Kimura, T.; Cheng, M.; Hayashi, Y.; Kiso, Y.
Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P(3)-cap moieties
Bioorg. Med. Chem.
16
5795-5802
2008
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Naka, H.; Teruya, K.; Bang, J.K.; Aimoto, S.; Tatsumi, T.; Konno, H.; Nosaka, K.; Akaji, K.
Evaluations of substrate specificity and inhibition at PR/p3 cleavage site of HTLV-1 protease
Bioorg. Med. Chem. Lett.
16
3761-3764
2006
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Kimura, T.; Nguyen, J.T.; Maegawa, H.; Nishiyama, K.; Arii, Y.; Matsui, Y.; Hayashi, Y.; Kiso, Y.
Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors
Bioorg. Med. Chem. Lett.
17
3276-3280
2007
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Nguyen, J.T.; Zhang, M.; Kumada, H.O.; Itami, A.; Nishiyama, K.; Kimura, T.; Cheng, M.; Hayashi, Y.; Kiso, Y.
Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors
Bioorg. Med. Chem. Lett.
18
366-370
2008
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K.
Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster
Bioorg. Med. Chem.
18
2720-2727
2010
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Satoh, T.; Li, M.; Nguyen, J.T.; Kiso, Y.; Gustchina, A.; Wlodawer, A.
Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease
J. Mol. Biol.
401
626-641
2010
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Nguyen, J.; Kato, K.; Kumada, H.; Hidaka, K.; Kimura, T.; Kiso, Y.
Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors
Bioorg. Med. Chem. Lett.
21
1832-1837
2011
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Nguyen, J.T.; Kato, K.; Hidaka, K.; Kumada, H.O.; Kimura, T.; Kiso, Y.
Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles
Bioorg. Med. Chem. Lett.
21
2425-2429
2011
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Li, C.; Li, X.; Lu, W.
Total chemical synthesis of human T-cell leukemia virus type 1 protease via native chemical ligation
Biopolymers
94
487-494
2010
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Rücker, P.; Horn, A.; Meiselbach, H.; Sticht, H.
A comparative study of HIV-1 and HTLV-I protease structure and dynamics reveals a conserved residue interaction network
J. Mol. Model.
17
2693-2705
2011
Human T-cell leukemia virus type I (P03362), Human T-cell leukemia virus type I, Human T-cell leukemia virus type I Japan ATK-1 subtype A (P03362)
Manually annotated by BRENDA team
Kumada, H.O.; Nguyen, J.T.; Kakizawa, T.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Kiso, Y.
Development of [Ile40]HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate
J. Pept. Sci.
17
569-575
2011
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Demir, A.; Oguariri, R.M.; Magis, A.; Ostrov, D.A.; Imamichi, T.; Dunn, B.M.
Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells
Antivir. Ther.
17
883-892
2012
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Ma, S.; Vogt, K.; Petrillo, N.; Ruhoff, A.
Characterizing the protonation states of the catalytic residues in apo and substrate-bound human T-cell leukemia virus type 1 protease
Comput. Biol. Chem.
56
61-70
2015
Human T-cell leukemia virus type I (Q82134), Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Selvaraj, C.; Singh, P.; Singh, S.K.
Molecular insights on analogs of HIV PR inhibitors toward HTLV-1 PR through QM/MM interactions and molecular dynamics studies: comparative structure analysis of wild and mutant HTLV-1 PR
J. Mol. Recognit.
27
696-706
2014
Human T-cell leukemia virus type I (P03362), Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Kuhnert, M.; Blum, A.; Steuber, H.; Diederich, W.E.
Privileged structures meet human T-cell leukemia virus-1 (HTLV-1) C2-symmetric 3,4-disubstituted pyrrolidines as nonpeptidic HTLV-1 protease inhibitors
J. Med. Chem.
58
4845-4850
2015
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Kheirabadi, M.; Maleki, J.; Soufian, S.; Hosseini, S.
Design of new potent HTLV-1 protease inhibitors in silico study
Mol. Biol. Res. Commun.
5
19-30
2016
Human T-cell leukemia virus type I
Manually annotated by BRENDA team
Selvaraj, C.; Omer, A.; Singh, P.; Singh, S.
Molecular insights of protein contour recognition with ligand pharmacophoric sites through combinatorial library design and MD simulation in validating HTLV-1 PR inhibitors
Mol. Biosyst.
11
178-189
2015
Human T-cell leukemia virus type I
Manually annotated by BRENDA team