3.4.23.B8: human T-cell leukemia virus type 1 protease

This is an abbreviated version!
For detailed information about human T-cell leukemia virus type 1 protease, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

C2A HTLV-1 PR, HTLV-1 PR, HTLV-1 protease, HTLV-I PR, HTLV-I protease, human T cell leukemia virus PR, human T cell leukemia virus protease, human T-cell leukemia virus type 1 protease, human T-lymphotropic virus type I protease, More, retropepsin (human T-cell leukemia virus), simian T-cell leukemia virus endopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B8 human T-cell leukemia virus type 1 protease

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Results	in table
2	AA Sequence
4	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Crystallization (Commentary)
6	General Information
68	IC50 Value
164	Inhibitors
11	kcat/KM [mM/s]
39	Ki Value [mM]
61	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
38	Organism
5	pH Optimum
1	pH Range
1	Posttranslational Modification
25	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
2	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
10	Subunits
27	Synonyms
5	Temperature Optimum [°C]
66	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.2

(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-F(NO2)-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid)

Human T-cell leukemia virus type I

-

pH 5.2, 37°C

647861

0.2

(((4-((4-dimethylamino)phenyl)azo)phenyl)sulfonyl)amino-(gamma-aminobutyric acid)-PQVL-PVMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid)

Human T-cell leukemia virus type I

-

pH 5.2, 37°C

647861

0.2

4-((4-dimethylaminophenylazo)benzoyl)-(gamma-aminobutyric acid)-PQVL-(4-nitro)Phe-VMH-(5-(2-aminoethylamino)-1-naphthalenesulfonic acid)

Human T-cell leukemia virus type I

-

pH 5.2, 37°C

647861

0.000065 - 0.0009

Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro-Leu

3 entries

0.023 - 2.16

APQVLF(NO2)VMHPL

3 entries

4.3 - 8.67

APQVLPVMHP

4 entries

0.143

APQVLPVMHPHG

Human T-cell leukemia virus type I

-

-

647858

0.0046 - 0.0057

dabsyl-(GABA)-PQVLPVMH-EDANS

2 entries

0.62 - 0.7

DPASILPVIP

3 entries

3.1

KAKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

1.1

KDKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

6.8

KGKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

6.26 - 6.91

KGPPVILPIQAP

2 entries

2.5

KLKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

2.3

KPKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

9.2

KSKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

2.4

KTAVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

2.3

KTDVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.44

KTFVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

1.2

KTGVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

1.5

KTKFLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

2.5

KTKILVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

3.3

KTKLLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

5.7

KTKVAVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

16.4

KTKVFVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.27

KTKVGVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.36

KTKVLFVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

1.5

KTKVLIVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

3.7

KTKVLLVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.006 - 10

KTKVLVVQPK

6 entries

4.1

KTKVMVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

11.7

KTKVYVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.52

KTLVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

2.08

KTSVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.48

KTVVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

2.7

KVKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.64 - 42.9

N6-(7-methoxycoumarin-4-yl)acetyl-L-Lys-L-Ala-L-Pro-L-Gln-L-Val-L-Leu-4-nitro-L-phenylalanine-L-Val-L-Met-L-His-L-Pro-L-Leu

2 entries

3.3

PPAILPIISE

Human T-cell leukemia virus type I

-

-

647862

0.00833

PPVMGVLDAP

Human T-cell leukemia virus type I

-

-

647862

0.22

PQVLPVMHP

Human T-cell leukemia virus type I

-

-

647862

2.7

TKVLVVQPK

2 entries

0.05

VSQIYPIVQ

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.05

VSQLYPIVQ

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.02

VSQVYPIVQ

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.085 - 0.184

YVEPTAPQVLPVMHP

3 entries

additional information

additional information

Human T-cell leukemia virus type I

-

-

647862

-

0.000065

Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro-Leu

Human T-cell leukemia virus type I

-

C-terminally truncated mutant of 122 residues, pH 5.6, 37°C

733121

0.00075

Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro-Leu

Human T-cell leukemia virus type I

-

C-terminally truncated mutant of 116 residues, pH 5.6, 37°C

733121

0.0009

Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro-Leu

Human T-cell leukemia virus type I

-

C-terminally truncated mutant of 121 residues, pH 5.6, 37°C

733121

0.023

APQVLF(NO2)VMHPL

Human T-cell leukemia virus type I

-

truncated enzyme, residues 1-116, 37°C, pH 5.6

717390

0.161

APQVLF(NO2)VMHPL

Human T-cell leukemia virus type I

-

full length enzyme, 37°C, pH 5.6

717390

2.16

APQVLF(NO2)VMHPL

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

4.3

APQVLPVMHP

Human T-cell leukemia virus type I

-

truncated enzyme, residues 1-116, 37°C, pH 5.6

717390

6.78

APQVLPVMHP

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, mutant enzyme L40I

647855

8.3

APQVLPVMHP

Human T-cell leukemia virus type I

-

full length enzyme, 37°C, pH 5.6

717390

8.67

APQVLPVMHP

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, wild-type enzyme

647855

0.0046

dabsyl-(GABA)-PQVLPVMH-EDANS

Human T-cell leukemia virus type I

-

pH 5.2, 37°C, modified L40I mutant enzyme lacking the 10 C-terminal amino acid residues

667390

0.0057

dabsyl-(GABA)-PQVLPVMH-EDANS

Human T-cell leukemia virus type I

-

pH 5.2, 37°C, modified L40I wild-type enzyme

667390

0.62

DPASILPVIP

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, mutant enzyme L40I

647855

0.7

DPASILPVIP

Human T-cell leukemia virus type I

-

-

647862

0.7

DPASILPVIP

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, wild-type enzyme

647855

6.26

KGPPVILPIQAP

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, mutant enzyme L40I

647855

6.91

KGPPVILPIQAP

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, wild-type enzyme

647855

0.006

KTKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851

2.8

KTKVLVVQPK

Human T-cell leukemia virus type I

-

truncated enzyme, residues 1-116, 37°C, pH 5.6

717390

5.15

KTKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, wild-type enzyme

647855

5.18

KTKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C, mutant enzyme L40I

647855

6.7

KTKVLVVQPK

Human T-cell leukemia virus type I

-

full length enzyme, 37°C, pH 5.6

717390

10

KTKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.64

N6-(7-methoxycoumarin-4-yl)acetyl-L-Lys-L-Ala-L-Pro-L-Gln-L-Val-L-Leu-4-nitro-L-phenylalanine-L-Val-L-Met-L-His-L-Pro-L-Leu

Human T-cell leukemia virus type I

-

His-tagged recombinant protein, pH 5.3, 37°C

718025

42.9

N6-(7-methoxycoumarin-4-yl)acetyl-L-Lys-L-Ala-L-Pro-L-Gln-L-Val-L-Leu-4-nitro-L-phenylalanine-L-Val-L-Met-L-His-L-Pro-L-Leu

Human T-cell leukemia virus type I

-

mutant L40I, pH 5.3, 37°C

718025

2.7

TKVLVVQPK

Human T-cell leukemia virus type I

-

-

647862

2.7

TKVLVVQPK

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

647854

0.085

YVEPTAPQVLPVMHP

Human T-cell leukemia virus type I

-

-

647862

0.085

YVEPTAPQVLPVMHP

Human T-cell leukemia virus type I

-

pH 5.0, 37°C

647849

0.184

YVEPTAPQVLPVMHP

Human T-cell leukemia virus type I

-

pH 5.3, 37°C

647851