3.4.23.B8: human T-cell leukemia virus type 1 protease

This is an abbreviated version!
For detailed information about human T-cell leukemia virus type 1 protease, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

C2A HTLV-1 PR, HTLV-1 PR, HTLV-1 protease, HTLV-I PR, HTLV-I protease, human T cell leukemia virus PR, human T cell leukemia virus protease, human T-cell leukemia virus type 1 protease, human T-lymphotropic virus type I protease, More, retropepsin (human T-cell leukemia virus), simian T-cell leukemia virus endopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B8 human T-cell leukemia virus type 1 protease

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Results	in table
2	AA Sequence
4	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Crystallization (Commentary)
6	General Information
68	IC50 Value
164	Inhibitors
11	kcat/KM [mM/s]
39	Ki Value [mM]
61	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
38	Organism
5	pH Optimum
1	pH Range
1	Posttranslational Modification
25	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
2	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
10	Subunits
27	Synonyms
5	Temperature Optimum [°C]
66	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.B8 - human T-cell leukemia virus type 1 protease

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

eukaryotic initiation factor eIF4GI + H2O

?

Human T-cell leukemia virus type I

-

in transfected COS-7 cells

667530

-

-

?

HTLV-1 Gag + H2O

?

Human T-cell leukemia virus type I

-

processing of the HTLV-1 Gag protein

647859

-

-

?

additional information

?

-

3 entries

additional information

?

-

Human T-cell leukemia virus type I

-

the enzyme produces the mature strucrtural proteins and enzymes essential for viral replication

647862

-

-

?

additional information

?

-

Human T-cell leukemia virus type I

-

the cleavage site between the capsid and the nucleocapsid protein of HTLV-1 is evolutionary optimized for rapid hydrolysis

647854

-

-

?

additional information

?

-

Human T-cell leukemia virus type I

-

no cleavage of poly(A)-binding protein in transfected COS-7 cells

667530

-

-

?