3.4.23.B8: human T-cell leukemia virus type 1 protease

This is an abbreviated version!
For detailed information about human T-cell leukemia virus type 1 protease, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

C2A HTLV-1 PR, HTLV-1 PR, HTLV-1 protease, HTLV-I PR, HTLV-I protease, human T cell leukemia virus PR, human T cell leukemia virus protease, human T-cell leukemia virus type 1 protease, human T-lymphotropic virus type I protease, More, retropepsin (human T-cell leukemia virus), simian T-cell leukemia virus endopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B8 human T-cell leukemia virus type 1 protease

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Results	in table
2	AA Sequence
4	Application
1	CAS Registry Number
9	Cloned(Commentary)
8	Crystallization (Commentary)
6	General Information
68	IC50 Value
164	Inhibitors
11	kcat/KM [mM/s]
39	Ki Value [mM]
61	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
38	Organism
5	pH Optimum
1	pH Range
1	Posttranslational Modification
25	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
2	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
10	Subunits
27	Synonyms
5	Temperature Optimum [°C]
66	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.23.B8 - human T-cell leukemia virus type 1 protease

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0000804

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-(2,2-dimethyl)butanoylamino-2-phenyl]acetylamino-3,3-dimethyl)-butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000842

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-(2-methyl)pentanoylamino-2-phenyl]acetylamino-3,3-dimethyl)- butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000833

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-(3,3-dimethyl)butanoylamino-2-phenyl]acetylamino-3,3-dimethyl)-butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0001017

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-(3-methyl)butanoylamino-2-phenyl]acetylamino-3,3-dimethyl)-butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000882

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-(3-methyl)pentanoylamino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0001048

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-(3-phenyl)-propanoylamino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000965

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-(4-methyl)pentanoylamino-2-phenyl]acetylamino-3,3-dimethyl) butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.000107

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-acetylamino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.000331

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-amino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenylbutanoyl))-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000792

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-benzoylamino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000982

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-cyclohexanecarbonylamino-2-phenyl]acetylamino-3,3-dimethyl)-butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000935

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-isobutyrylamino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.000092

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-pentanoylamino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0001045

(R)-N-isobutyl-3-(((2S,3S)-3-((2S)-2-[(2S)-2-propionylamino-2-phenyl]acetylamino-3,3-dimethyl)butanoylamino-2-hydroxy-4-phenyl))butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0001043

(R)-N-isobutyl-3-[[(2S,3S)-3-[(2S)-2-[(2S)-2-butyrylamino-2-phenyl]acetylamino-3,3-dimethyl]butanoylamino-2-hydroxy-4-phenyl]]butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.0000969

(R)-N-isobutyl-3-[[(2S,3S)-3-[(2S)-2-[(2S)-2-cyclopropanecarbonylamino-2-phenyl]acetylamino-3,3-dimethyl]butanoylamino-2-hydroxy-4-phenyl]]butanoyl-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Human T-cell leukemia virus type I

-

assay performed with mutant L40I

678624

0.000113

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2,2-dimethylpropyl)amino)

Human T-cell leukemia virus type I

-

-

691286

0.00014

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2-methylprop-2-en-1-yl)amino)

Human T-cell leukemia virus type I

-

-

691286

0.000107

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((2-methylpropyl)amino)

Human T-cell leukemia virus type I

-

-

691286

0.000146

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-((cyclopropyl)amino)

Human T-cell leukemia virus type I

-

-

691286

0.000103

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(2-methylbenzylamino)

Human T-cell leukemia virus type I

-

-

691286

0.000473

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(3-iodobenzylamino)

Human T-cell leukemia virus type I

-

-

691286

0.000131

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(prop-2-en-1-ylamino)

Human T-cell leukemia virus type I

-

-

691286

0.000193

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(propylamino)

Human T-cell leukemia virus type I

-

-

691286

0.000084

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Gln-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000101

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000144

acetyl-(L-(+)-alpha-phenylglycine)-(L-tert-leucine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000102

acetyl-(L-(+)-alpha-phenylglycine)-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000201

acetyl-(L-tert-leucine)-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000353

acetyl-Gln-Val-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Val-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000145 - 0.00032

acetyl-Ile-(L-(+)-alpha-phenylglycine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

2 entries

0.000123

acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(L-(+)-alpha-phenylglycine)-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.00018

acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-(L-tert-leucine)-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.00016

acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Ala-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000159

acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Gln-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000088

acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000249

acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-NH2

Human T-cell leukemia virus type I

-

-

691286

0.000095

acetyl-Ile-Ile-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Phe-NH2

Human T-cell leukemia virus type I

-

-

691286

0.00018

acetyl-Ile-Ile-(phenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.0024

H-Pro-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I

Human T-cell leukemia virus type I

-

-

678636

0.00013

H-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-Ile-NHCH2C6H5I

Human T-cell leukemia virus type I

-

-

678636

0.0058

H-Pro-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I

Human T-cell leukemia virus type I

-

-

678636

0.0183

H-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-Ile-NHCH2C6H5I

Human T-cell leukemia virus type I

-

-

678636

0.0196

H-Val-Ile-NHCH(CH2CH(CH3)2)CH(OH)CH2-Pro-NHCH2C6H5I

Human T-cell leukemia virus type I

-

-

678636

0.000015

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(4-amino-N-benzylbenzenesulfonamide)

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

0.0024

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-chlorobenzenesulfonamide)

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.0026

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-methylbenzenesulfonamide)

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.0079

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-4-nitrobenzenesulfonamide)

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.002

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzylbenzenesulfonamide)

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.0178

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(2-methylprop-2-en-1-yl)benzenesulfonamide]

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.0116

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(3-methylbut-2-en-1-yl)benzenesulfonamide]

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.2

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(4-iodobenzyl)benzenesulfonamide]

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

0.1725

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-(prop-2-en-1-yl)benzenesulfonamide]

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.25

N,N'-(3S,4S)-pyrrolidine-3,4-diylbis[N-[4-(trifluoromethyl)benzyl]benzenesulfonamide]

Human T-cell leukemia virus type I

-

pH and temperature not specified in the publication

754373

-

0.35

N-[(2R)-2-[(1R)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide

Human T-cell leukemia virus type I

-

in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication

711453

1.5

N-[(2R)-2-[(1S)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide

Human T-cell leukemia virus type I

-

in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication

711453

0.16

N-[(2S)-2-[(1R)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide

Human T-cell leukemia virus type I

-

in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication

711453

0.55

N-[(2S)-2-[(1S)-2-[(2R)-1-(benzylcarbamoyl)pyrrolidin-2-yl]-1-hydroxyethyl]-4-methylpentanoyl]-D-isoleucyl-D-valyl-D-prolyl-D-prolinamide

Human T-cell leukemia virus type I

-

in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication

711453

0.0000072

N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-N2-[(2S)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-3-methyl-L-valinamide

Human T-cell leukemia virus type I

-

recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication

717341

0.0000104

N-[(2S)-4-[(4R)-4-[(2-tert-butylhydrazinyl)carbonyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-N2-[(2S)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-3-methyl-L-valinamide

Human T-cell leukemia virus type I

-

recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication

717341

10

N-[(2S,3R)-3-(acetylamino)-2-hydroxy-5-methylhexyl]-D-isoleucyl-D-valyl-D-prolinamide

Human T-cell leukemia virus type I

-

IC50 above 10 mM, in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication

711453

10

N-[(2S,3R)-3-[(1-acetyl-D-prolyl)amino]-2-hydroxy-5-methylhexyl]-D-isoleucyl-D-valyl-D-prolinamide

Human T-cell leukemia virus type I

-

IC50 above 10 mM, in 0.5 M sodium acetate buffer, pH 5.6, containing 10% (v/v) glycerol, 10 mM dithiothretiol and 4 M NaCl, temperature not specified in the publication

711453

0.0000057

N2-[(2S)-2-(b-alanylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide

Human T-cell leukemia virus type I

-

recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication

717341

0.0000064

N2-[(2S)-2-(butanoylamino)-2-phenylacetyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide

Human T-cell leukemia virus type I

-

recombinant protease mutant L40I, pH not specified in the publication, temperature not specified in the publication

717341

0.000013

N2-[(2S)-2-amino-2-(2,4,6-trifluorophenyl)ethyl]-N-[(2S)-4-[(4R)-4-[(2,2-dimethylpropyl)carbamoyl]-5,5-dimethyl-1,3-thiazolidin-3-yl]-4-oxo-1-phenylbutan-2-yl]-3-methyl-L-valinamide

Human T-cell leukemia virus type I

-

pH 5.6, 37°C

717338

0.000152

Pro-Gln-Val-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Val-Met-His-Pro

Human T-cell leukemia virus type I

-

-

691286

0.000159

Pro-Gln-Val-allophenylnorstatine-Pro-Val-Met-His-Pro

Human T-cell leukemia virus type I

-

-

691286

0.000145

acetyl-Ile-(L-(+)-alpha-phenylglycine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

Human T-cell leukemia virus type I

-

-

691286

0.00032

acetyl-Ile-(L-(+)-alpha-phenylglycine)-(allophenylnorstatine)-[(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid]-Ile-Met-NH2

Human T-cell leukemia virus type I

-

-

691286