3.4.23.B4: Feline immunodeficiency virus protease
This is an abbreviated version!
For detailed information about Feline immunodeficiency virus protease, go to the full flat file.
Word Map on EC 3.4.23.B4
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3.4.23.B4
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broad-based
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polyproteins
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retroviral
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drug-resistant
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gag-pol
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flap
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subsites
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val
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calicivirus
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lopinavir
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lentivirus
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virions
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medicine
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molecular biology
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drug development
- 3.4.23.B4
-
broad-based
- polyproteins
-
retroviral
-
drug-resistant
- gag-pol
- flap
-
subsites
- val
- calicivirus
- lopinavir
- lentivirus
- virions
- medicine
- molecular biology
- drug development
Reaction
the enzyme seems to have a preference for Val in P1' and Phe in P1. In contrast to the HIV-1 protease the feline immunodeficiency virus protease does not cleave the peptide KSGVFVQNGLVK at the Phe-Val bond. Gln in P2' may be inhibitory. In contrast to HIV-1 protease the feline immunodeficiency virus protease does not cleave peptide KSGNFVVNGLVK at the Phe-Val bond. Asn in P2 may be inhibitory =
Synonyms
FCV protease, feline immunodeficiency virus protease, Feline immunodeficiency virus retropepsin, FIV PR, FIV protease, FIV retropepsin, FIV-PR, More
ECTree
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KM Value
KM Value on EC 3.4.23.B4 - Feline immunodeficiency virus protease
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0.013
Arg-Ala-Leu-Thr-Lys-(4-aminobenzoic acid)-Val-Gln-Phe-(NO2)-Val-Gln-Ser-Lys-Gly-Arg-NH2
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0.033
RALTK(epsilon-ABZ)VQF(NO2)VQSKGR
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pH 5.3, 0.2 M NaCl, 0.1 mM EDTA, 1 mM DTT
0.0056
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pH 5.25, mutant enzyme I37V/V59I
0.01
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme I37V
0.0114
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme V59I
0.0156
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme N55M
0.0159
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme I37V/N55M
0.018
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme Q99V
0.0193
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme L97T/I98P/Q99V/P100N/L101I
0.0204
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
pH 5.25, wild-type enzyme
0.0205
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme I37V/M56I
0.0244
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme L101I
0.0256
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, wild-type enzyme
0.0278
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme M56I
0.0351
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme I98P
0.0372
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme I37V/Q54K
0.156
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme Q54K
0.271
Ala-Leu-Thr-Lys-Val-Gln-Val-Val-Gln-Ser-Lys-Gly
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pH 5.25, mutant enzyme I57G/G62F
0.462
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pH 5.25, mutant enzyme Q99V
0.542
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly
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pH 5.25, mutant enzyme I37V
0.582
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly
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pH 5.25, mutant enzyme N55M
0.739
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly
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pH 5.25, mutant enzyme I37V/N55M
0.832
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly
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pH 5.25, mutant enzyme I37V/V59I
1.183
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly
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pH 5.25, mutant enzyme V59I
1.4
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly
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pH 5.25, wild-type enzyme
1.845
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly
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pH 5.25, mutant enzyme M56I
additional information
Km-values for multiple-substitution mutants constructed by replacing the residues in and around the active site of the enzyme with structurally equivalent residues of HIV-1 protease
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additional information
additional information
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Km-values for multiple-substitution mutants constructed by replacing the residues in and around the active site of the enzyme with structurally equivalent residues of HIV-1 protease
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additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
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Michaelis-Menten kinetics
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