3.4.23.B4: Feline immunodeficiency virus protease

This is an abbreviated version!
For detailed information about Feline immunodeficiency virus protease, go to the full flat file.

Word Map on EC 3.4.23.B4

3.4.23.B4

broad-based

polyproteins

retroviral

drug-resistant

gag-pol

flap

subsites

val

calicivirus

lopinavir

lentivirus

virions

medicine

molecular biology

drug development

Reaction

the enzyme seems to have a preference for Val in P1' and Phe in P1. In contrast to the HIV-1 protease the feline immunodeficiency virus protease does not cleave the peptide KSGVFVQNGLVK at the Phe-Val bond. Gln in P2' may be inhibitory. In contrast to HIV-1 protease the feline immunodeficiency virus protease does not cleave peptide KSGNFVVNGLVK at the Phe-Val bond. Asn in P2 may be inhibitory =

Synonyms

FCV protease, feline immunodeficiency virus protease, Feline immunodeficiency virus retropepsin, FIV PR, FIV protease, FIV retropepsin, FIV-PR, More

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.B4 Feline immunodeficiency virus protease

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Results	in table
3	AA Sequence
5	Application
1	CAS Registry Number
5	Cloned(Commentary)
8	Crystallization (Commentary)
2	General Information
39	IC50 Value
64	Inhibitors
7	Ki Value [mM]
30	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
29	Organism
3	pH Optimum
1	pH Stability
3	Posttranslational Modification
53	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
25	Reference
52	Substrates and Products (Substrate)
5	Subunits
22	Synonyms
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
26	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.23.B4 - Feline immunodeficiency virus protease

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0.000128

(1-[1-[1-(4-[2-[2-(2-Benzyloxycarbonylamino-3-hydroxy-propionylamino)-propionylamino]-3-methyl-butyrylamino]-2,3-dihydroxy-1,4-diphenyl-butylcarbamoyl)-2-methyl-propylcarbamoyl]-ethylcarbamoyl]-2-hydroxy-ethyl)-carbamic acid benzyl ester

feline immunodeficiency virus

IC50: 128 nM

647837

0.67

(3S,4R,5R,6S)-3,6-di-O-(3',5'-difluorobenzyl)-3,4,5,6-tetrahydroxyazepane

feline immunodeficiency virus

IC50: 0.67 mM

647831

1.4

(3S,4R,5R,6S)-3,6-di-O-(3'-fluorobenzyl)-3,4,5,6-tetrahydroxyazepane

feline immunodeficiency virus

IC50: 1.4 mM

647831

0.000138

2-(2-Benzenesulfonylamino-propionylamino)-N-[4-[2-(2-benzenesulfonylamino-propionylamino)-3-methyl-butyrylamino]-2,3-dihydroxy-1,4-diphenyl-butyl]-3-methyl-butyramide

feline immunodeficiency virus

IC50: 138 nM

647837

0.000141

2-[2-(4-Bromo-benzenesulfonylamino)-propionylamino]-N-(4-[2-[2-(4-bromo-benzenesulfonylamino)-propionylamino]-3-methyl-butyrylamino]-2,3-dihydroxy-1,4-diphenyl-butyl)-3-methyl-butyramide

feline immunodeficiency virus

IC50: 141 nM

647837

0.000212

2-[2-Acetylamino-3-(1H-indol-3-yl)-propionylamino]-N-(4-[2-[2-acetylamino-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino]-1-benzyl-2,3-dihydroxy-5-phenyl-pentyl)-3-methyl-butyramide

feline immunodeficiency virus

IC50: 212 nM

647837

0.000048

3-(2-Hydroxy-3-[2-[2-(hydroxy-methyl-amino)-3-phenyl-propionylamino]-3-methyl-butyrylamino]-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carboxylic acid (2-methoxyamino-3-methyl-butyryl)-amide

feline immunodeficiency virus

IC50: 48 nM

647837

0.000117

3-(2-Hydroxy-3-[2-[2-(hydroxy-methyl-amino)-3-phenyl-propionylamino]-3-methyl-butyrylamino]-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carboxylic acid (3-methyl-2-methylamino-butyryl)-amide

feline immunodeficiency virus

IC50: 117 nM

647837

0.000182

3-(2-Hydroxy-3-[2-[2-(hydroxy-methyl-amino)-propionylamino]-3-methyl-butyrylamino]-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carboxylic acid (2-methoxyamino-3-methyl-butyryl)-amide

feline immunodeficiency virus

IC50: 182 nM

647837

0.000256

3-(3-[2-[2-Acetylamino-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino]-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carboxylic acid (2-methoxyamino-3-methyl-butyryl)-amide

feline immunodeficiency virus

IC50: 256 nM

647837

0.00008

3-(3-[2-[2-Acetylamino-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino]-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carboxylic acid (3-methyl-2-methylamino-butyryl)-amide

feline immunodeficiency virus

IC50: 80 nM

647837

0.0012

3-(3-[2-[2-Acetylamino-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino]-2-hydroxy-4-phenyl-butyryl)-thiazolidine-4-carboxylic acid (2-methoxyamino-3-methyl-butyryl)-amide

feline immunodeficiency virus

IC50: 0.0012 mM

647837

0.0187

GC376

feline calicivirus

Q66914

pH 7.5, 37°C, recombinant enzyme

755654

0.0004

Gly-Ser-Gly-Val-Phe[CH2NH]-Val-Val-Asn-Gly-Leu

feline immunodeficiency virus

P16088

IC50: 0.0004 mM

647834

0.005

Gly-Ser-Gly-Val-Phe[CHOHCH2]-Val-Val-Asn-Gly-Leu

feline immunodeficiency virus

P16088

IC50: 0.005 mM

647834

0.00031

N-(2,3-Dihydroxy-4-[2-[2-(4-methoxy-benzenesulfonylamino)-propionylamino]-3-methyl-butyrylamino]-1,4-diphenyl-butyl)-2-[2-(4-methoxy-benzenesulfonylamino)-propionylamino]-3-methyl-butyramide

feline immunodeficiency virus

IC50: 310 nM

647837

0.2

N-(2,3-Dihydroxy-4-[3-methyl-2-[2-(3-p-tolyl-ureido)-propionylamino]-butyrylamino]-1,4-diphenyl-butyl)-3-methyl-2-[2-(3-p-tolyl-ureido)-propionylamino]-butyramide

feline immunodeficiency virus

IC50: 0.2 mM

647837

0.000017

N-(2,3-Dihydroxy-4-[3-methyl-2-[2-(toluene-4-sulfonylamino)-propionylamino]-butyrylamino]-1,4-diphenyl-butyl)-3-methyl-2-[2-(4-methyl-cyclohexa-1,3-dienesulfonylamino)-propionylamino]-butyramide

feline immunodeficiency virus

IC50: 17 nM

647837

0.000228

N-(2,3-Dihydroxy-4-[3-methyl-2-[2-(toluene-4-sulfonylamino)-propionylamino]-butyrylamino]-1,4-diphenyl-butyl)-3-methyl-2-[2-(4-nitro-cyclohexa-1,3-dienesulfonylamino)-propionylamino]-butyramide

feline immunodeficiency virus

IC50: 228 nM

647837

0.000156

N-[1-(1-[4-[2-(2-Benzoylamino-propionylamino)-3-methyl-butyrylamino]-2,3-dihydroxy-1,4-diphenyl-butylcarbamoyl]-2-methyl-propylcarbamoyl)-ethyl]-benzamide

feline immunodeficiency virus

IC50: 156 nM

647837

0.2

N-[2,3-Dihydroxy-4-(2-[2-[3-(4-methoxy-phenyl)-ureido]-propionylamino]-3-methyl-butyrylamino)-1,4-diphenyl-butyl]-2-[2-[3-(4-methoxy-phenyl)-ureido]-propionylamino]-3-methyl-butyramide

feline immunodeficiency virus

IC50: 0.2 mM

647837

0.119

N-[2,3-Dihydroxy-4-(3-methyl-2-[2-[3-(4-trifluoromethoxy-phenyl)-ureido]-propionylamino]-butyrylamino)-1,4-diphenyl-butyl]-3-methyl-2-[2-[3-(4-trifluoromethoxy-phenyl)-ureido]-propionylamino]-butyramide

feline immunodeficiency virus

IC50: 0.119 mM

647837

0.2

N-[2,3-Dihydroxy-4-(3-methyl-2-[2-[3-(4-trifluoromethyl-phenyl)-ureido]-propionylamino]-butyrylamino)-1,4-diphenyl-butyl]-3-methyl-2-[2-[3-(4-trifluoromethyl-phenyl)-ureido]-propionylamino]-butyramide

feline immunodeficiency virus

IC50: 0.2 mM

647837

0.000118

N-[2,3-Dihydroxy-4-[3-methyl-2-(2-phenylmethanesulfonylamino-propionylamino)-butyrylamino]-1,4-diphenyl-butyl]-3-methyl-2-(2-phenylmethanesulfonylamino-propionylamino)-butyramide

feline immunodeficiency virus

IC50: 118 nM

647837

0.0027

PPNDS

feline calicivirus

Q66914

pH 7.5, 37°C, recombinant enzyme

755654

0.0011

protease inhibitor AB-2

feline immunodeficiency virus

a HIV-1 protease inhibitor, IC50: 0.0011 mM

670098

0.001

protease inhibitor AB-6

feline immunodeficiency virus

a HIV-1 protease inhibitor, IC50: 0.001 mM

670098

0.008

protease inhibitor AB-8

feline immunodeficiency virus

a HIV-1 protease inhibitor, IC50: 0.008 mM

670098

0.001

protease inhibitor APV-1

feline immunodeficiency virus

a HIV-1 protease inhibitor, IC50: 0.001 mM

670098

0.045

protease inhibitor RTV

feline immunodeficiency virus

a HIV-1 protease inhibitor, weak inhibition of wild-type FIV protease, IC50: 0.045 mM

670098

0.00009

protease inhibitor TL-3

feline immunodeficiency virus

IC50: 90 nM

670098

0.0028

quercetagetin

feline calicivirus

Q66914

pH 7.5, 37°C, recombinant enzyme

755654

0.0001

TL3

feline immunodeficiency virus

IC50: 100 nM

647837

0.0002

[1-(1-[1-Benzyl-2,3,3-trihydroxy-3-[4-(2-methoxyamino-3-methyl-butyrylcarbamoyl)-5,5-dimethyl-thiazolidin-3-yl]-propylcarbamoyl]-2-methyl-propylcarbamoyl)-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

IC50: 200 nM

647837

0.001

[1-(1-[1-Benzyl-2-hydroxy-3-[4-(2-methoxyamino-3-methyl-butyrylcarbamoyl)-5,5-dimethyl-thiazolidin-3-yl]-3-oxo-propylcarbamoyl]-2-methyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

IC50: 0.001 mM

647837

0.019

[1-(1-[1-Benzyl-2-hydroxy-3-[4-(2-methoxyamino-3-methyl-butyrylcarbamoyl)-5,5-dimethyl-thiazolidin-3-yl]-3-oxo-propylcarbamoyl]-2-methyl-propylcarbamoyl)-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

IC50: 0.019 mM

647837

0.0052

[1-(1-[1-Benzyl-2-hydroxy-3-[4-(2-methoxyamino-3-methyl-butyrylcarbamoyl)-5,5-dimethyl-thiazolidin-3-yl]-propylcarbamoyl]-2-methyl-propylcarbamoyl)-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

IC50: 0.0052 mM

647837

0.0001

[1-(1-[4-[2-(2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-2,3-dihydroxy-1,4-diphenyl-butylcarbamoyl]-2-methyl-propylcarbamoyl)-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

IC50: 100 nM

647837

0.000095

[1-[1-(1-Benzyl-3-[4-[2-(2-benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylcarbamoyl]-5,5-dimethyl-thiazolidin-3-yl]-2,3,3-trihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

IC50: 95 nM

647837