3.4.23.B4: Feline immunodeficiency virus protease

This is an abbreviated version!
For detailed information about Feline immunodeficiency virus protease, go to the full flat file.

Reaction

the enzyme seems to have a preference for Val in P1' and Phe in P1. In contrast to the HIV-1 protease the feline immunodeficiency virus protease does not cleave the peptide KSGVFVQNGLVK at the Phe-Val bond. Gln in P2' may be inhibitory. In contrast to HIV-1 protease the feline immunodeficiency virus protease does not cleave peptide KSGNFVVNGLVK at the Phe-Val bond. Asn in P2 may be inhibitory =

Synonyms

FCV protease, feline immunodeficiency virus protease, Feline immunodeficiency virus retropepsin, FIV PR, FIV protease, FIV retropepsin, FIV-PR, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B4 Feline immunodeficiency virus protease

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Results	in table
3	AA Sequence
5	Application
1	CAS Registry Number
5	Cloned(Commentary)
8	Crystallization (Commentary)
2	General Information
39	IC50 Value
64	Inhibitors
7	Ki Value [mM]
30	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
29	Organism
3	pH Optimum
1	pH Stability
3	Posttranslational Modification
53	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
25	Reference
52	Substrates and Products (Substrate)
5	Subunits
22	Synonyms
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
26	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.23.B4 - Feline immunodeficiency virus protease

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00026

Ac-naphthylalanine-Val-statine-Glu-naphthylalanine-NH2

feline immunodeficiency virus

-

-

668799

0.076

Ro31-8959

feline immunodeficiency virus

P16088

pH 5.25, 37°C

647830

0.000156

[(1-[1-benzyl-4-[2-(2-benzyloxycarbonylamino-acetylamino)-3-methyl-butyrylamino]-2,3-dihydroxy-5-phenyl-pentylcarbamoyl]-2-methyl-propylcarbamoyl)-methyl]-carbamic acid benzyl ester

feline immunodeficiency virus

-

-

647837

0.007

[1-(1-[1-benzyl-4-[2-(2-benzyloxycarbonylamino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-2,3-dihydroxy-5-phenyl-pentylcarbamoyl]-2-methyl-propylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

-

-

647837

0.000159

[1-(1-[1-benzyl-4-[2-(2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-2,3-dihydroxy-5-phenyl-pentylcarbamoyl]-2-methyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

feline immunodeficiency virus

-

-

647837

0.000041

[1-(1-[1-benzyl-4-[2-(2-benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-2,3-dihydroxy-5-phenyl-pentylcarbamoyl]-2-methyl-propylcarbamoyl)-ethyl]-carbamic acid benzyl ester

feline immunodeficiency virus

-

-

647837

additional information

additional information

feline immunodeficiency virus

-

-

668799

-