3.4.23.B4: Feline immunodeficiency virus protease
This is an abbreviated version!
For detailed information about Feline immunodeficiency virus protease, go to the full flat file.
Word Map on EC 3.4.23.B4
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3.4.23.B4
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broad-based
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polyproteins
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retroviral
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drug-resistant
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gag-pol
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flap
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subsites
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val
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calicivirus
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lopinavir
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lentivirus
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virions
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medicine
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molecular biology
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drug development
- 3.4.23.B4
-
broad-based
- polyproteins
-
retroviral
-
drug-resistant
- gag-pol
- flap
-
subsites
- val
- calicivirus
- lopinavir
- lentivirus
- virions
- medicine
- molecular biology
- drug development
Reaction
the enzyme seems to have a preference for Val in P1' and Phe in P1. In contrast to the HIV-1 protease the feline immunodeficiency virus protease does not cleave the peptide KSGVFVQNGLVK at the Phe-Val bond. Gln in P2' may be inhibitory. In contrast to HIV-1 protease the feline immunodeficiency virus protease does not cleave peptide KSGNFVVNGLVK at the Phe-Val bond. Asn in P2 may be inhibitory =
Synonyms
FCV protease, feline immunodeficiency virus protease, Feline immunodeficiency virus retropepsin, FIV PR, FIV protease, FIV retropepsin, FIV-PR, More
ECTree
3.4.23.B4 Feline immunodeficiency virus proteaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.23.B4 - Feline immunodeficiency virus protease
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
feline apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 protein + H2O
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APOBEC3, FIV protease cleaves feline APOBEC3, A3Z2Z3, in released virions. The leucine residue at position 232 of feline A3Z2Z3 is related to cleavage by FIV PR
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Gag-Pol polyprotein + H2O
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processing of the precursor protein
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Gag-Pol polyprotein + H2O
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processing of the precursor protein into several mature proteins
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?
Gag-Pol polyprotein + H2O
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FIV PR cleaves Gag polyprotein into 5 individual proteins, including matrix, capsid, p1, nucleocapsid, and p2
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Gag-Pol polyprotein + H2O
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the Gag precursor is cleaved into the final mature Gag proteins matrix, capsid, nucleocapsid, spacer peptides (SP1, SP2), flanking nucleocapsid, and the C-terminal peptide p2
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Gag-Pol polyprotein + H2O
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processing of the precursor protein into several mature proteins
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?
Gag-Pol polyprotein + H2O
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processing of the precursor protein
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additional information
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the enzyme is essential for virion maturation and subsequent viral replication in that it cleaves the Gag and Gag/Pol polyproteins at eight sites to release the respective structural proteins and enzymes
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additional information
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feline immunodeficiency virus induces neurological deficits in the central nervous system of host cats which can be prevented by treatment with the feline immunodeficiency virus protease inhibitor TL-3, overview
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additional information
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the enzyme performs autolytic processing of the precursor protein of which it is a part, cutting out itself and other proteins, the Gag polyprotein occurs in different splicing forms and sizes of 50-60 kDa to 150-200 kDa
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additional information
?
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the enzyme performs autolytic processing of the precursor protein of which it is a part, cutting out itself and other proteins, the Gag polyprotein occurs in different splicing forms and sizes of 50-60 kDa to 150-200 kDa
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?
