3.4.23.B4: Feline immunodeficiency virus protease

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For detailed information about Feline immunodeficiency virus protease, go to the full flat file.

Reaction

the enzyme seems to have a preference for Val in P1' and Phe in P1. In contrast to the HIV-1 protease the feline immunodeficiency virus protease does not cleave the peptide KSGVFVQNGLVK at the Phe-Val bond. Gln in P2' may be inhibitory. In contrast to HIV-1 protease the feline immunodeficiency virus protease does not cleave peptide KSGNFVVNGLVK at the Phe-Val bond. Asn in P2 may be inhibitory =

Synonyms

FCV protease, feline immunodeficiency virus protease, Feline immunodeficiency virus retropepsin, FIV PR, FIV protease, FIV retropepsin, FIV-PR, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B4 Feline immunodeficiency virus protease

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Results	in table
3	AA Sequence
5	Application
1	CAS Registry Number
5	Cloned(Commentary)
8	Crystallization (Commentary)
2	General Information
39	IC50 Value
64	Inhibitors
7	Ki Value [mM]
30	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
29	Organism
3	pH Optimum
1	pH Stability
3	Posttranslational Modification
53	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
25	Reference
52	Substrates and Products (Substrate)
5	Subunits
22	Synonyms
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
26	Turnover Number [1/s]

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General Information on EC 3.4.23.B4 - Feline immunodeficiency virus protease

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

feline immunodeficiency virus

A0A059UHW3

mammalian apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins act as intrinsic restriction factors against lentiviruses. Viral infectivity factor (Vif) degrades host APOBEC3 proteins via a ubiquitin/proteasome-dependent pathway. FIV protease cleaves feline APOBEC3 in released virions. Thus, lentivirus encodes two types of anti-APOBEC3 factors, Vif and viral protease

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physiological function

feline immunodeficiency virus

A0A059UHW3

FIV protease cleaves feline APOBEC3 A3Z2Z3 in released virions. FIV PR-mediated cleavage of feline A3Z2Z3 potently contributes to counteracting the antiviral effect mediated by feline A3Z2Z3

754552