3.4.23.50: human endogenous retrovirus K endopeptidase

This is an abbreviated version!
For detailed information about human endogenous retrovirus K endopeptidase, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

endogenous retrovirus encoded protease, endogenous retrovirus HERV-K10 putative protease, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K(HML-2) Pro, HERV-K(HML-2) protease, HERV-K113 protease, HML-2 Pro, human endogenous retrovirus K retropepsin, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin, More

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.50 human endogenous retrovirus K endopeptidase

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1	Activating Compound
103	AA Sequence
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8	Cloned(Commentary)
3	Disease/ Diagnostics
1	General Information
31	Inhibitors
40	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
11	Organism
2	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
2	Posttranslational Modification
2	Protein Variants
4	Purification (Commentary)
2	Reaction
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11	Reference
16	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
4	Turnover Number [1/s]

Purification

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Purification on EC 3.4.23.50 - human endogenous retrovirus K endopeptidase

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18200 Da enzyme form and 11600 Da core domain

Homo sapiens

646017

full-length and C-terminally truncated enzyme in Escherichia coli

Homo sapiens

646018

native enzyme by pepstatin A affinity chromatography

Human endogenous retrovirus K

754663

recombinant wild-type and C-terminally truncated mutant enzymes from Escherichia coli by ammonium sulfate fractionation, cation and anion exchange chromatography, and hydrophobic interaction chromatography, or recombinant C-terminally truncated mutant enzyme from inclusion bodies by dialysis and pepstatin A affinity chromatography followed by autoprocession to active, soluble enzme

Homo sapiens

668800