3.4.23.50: human endogenous retrovirus K endopeptidase

This is an abbreviated version!
For detailed information about human endogenous retrovirus K endopeptidase, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

endogenous retrovirus encoded protease, endogenous retrovirus HERV-K10 putative protease, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K(HML-2) Pro, HERV-K(HML-2) protease, HERV-K113 protease, HML-2 Pro, human endogenous retrovirus K retropepsin, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.50 human endogenous retrovirus K endopeptidase

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Results	in table
1	Activating Compound
103	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
3	Disease/ Diagnostics
1	General Information
31	Inhibitors
40	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
11	Organism
2	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
2	Posttranslational Modification
2	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
11	Reference
16	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
4	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.50 - human endogenous retrovirus K endopeptidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Gag polyprotein + H2O

?

Homo sapiens

-

the enzyme is synthesized as part of the Gag polyprotein or the Gag-Pol polyprotein and autolytically processed to the mature dimer

668800

-

-

?

Gag-Pol polyprotein + H2O

?

Homo sapiens

-

the enzyme is synthesized as part of the Gag polyprotein or the Gag-Pol polyprotein and autolytically processed to the mature dimer

668800

-

-

?

additional information

?

-

3 entries

additional information

?

-

Homo sapiens

-

the results do not exclude the possibility that the HERV-K PR could complement an HIV-1 PR whoses function is impaired due to drugs or drug-resistant mutations, they clearly demomstrate that the HERV-K PR cannot substitute for the function of the wild-type HIV-1 PR

646019

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme probably functions in the processing of Gag precursor protein

646020

-

-

?

additional information

?

-

Human endogenous retrovirus K

-

hundreds of cellular proteins are potential substrates of enzyme HERV-K(HML-2) Pro

754663

-

-

?