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Literature summary for 3.4.23.50 extracted from

  • Kuhelj, R.; Rizzo, C.J.; Chang, C.H.; Jadhav, P.K.; Towler, E.M.; Korant, B.D.
    Inhibition of human endogenous retrovirus-K10 protease in cell-free and cell-based assays (2001), J. Biol. Chem., 276, 16674-16682.
    View publication on PubMed
Search for more literature for 3.4.23.50

Cloned(Commentary)

Cloned (Comment) Organism
expression of a full-length and C-terminally truncated enzyme in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
indinavir
-
 Homo sapiens
pepstatin
-
 Homo sapiens
Q8467
-
 Homo sapiens
ritonavir
-
 Homo sapiens
saquinavir
-
 Homo sapiens
SD145
-
 Homo sapiens
SD146 efficiently blocks HERV-K Gag processing in vitro and in cells Homo sapiens
SD152
-
 Homo sapiens
XK234
-
 Homo sapiens
XM412
-
 Homo sapiens
XV638
-
 Homo sapiens
XV643
-
 Homo sapiens
XV644
-
 Homo sapiens
XV648
-
 Homo sapiens
XV651
-
 Homo sapiens
XV652
-
 Homo sapiens
XW805
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 2-aminobenzoyl-Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.041
-
 2-aminobenzoyl-Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
full-length and C-terminally truncated enzyme in Escherichia coli Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
-
 Homo sapiens ?
-
 ?
HERV-K Gag polyprotein + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.13
-
 2-aminobenzoyl-Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
1.37
-
 2-aminobenzoyl-Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000001
-
 XV648 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00000015
-
 SD146 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00000017
-
 XV643 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00000022
-
 XV644 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00000052
-
 XV652 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.0000022
-
 XV638 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.0000023
-
 XV648 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.0000029
-
 XV644 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.0000032
-
 XV651 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.0000033
-
 XV652 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.0000036
-
 XW805 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.0000039
-
 XV643 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.0000043
-
 SD146 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.0000059
-
 SD145 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.0000079
-
 SD152 pH 5.0, 25°C, 13000 Da enzyme form Homo sapiens
0.0000162
-
 Q8467 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00002
-
 XV638 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.000027
-
 SD152 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.00003
-
 SD145 pH 5.0, 25°C, 13000 Da enzyme form Homo sapiens
0.000031
-
 XW805 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.000043
-
 XV651 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.000061
-
 Q8467 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.000091
-
 XM412 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00039
-
 XM412 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.00061
-
 indinavir pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00067
-
 XK234 pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00094
-
 indinavir pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.00113
-
 ritonavir pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00121
-
 ritonavir pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.00187
-
 XK234 pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.00257
-
 pepstatin pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.00258
-
 saquinavir pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form Homo sapiens
0.0049
-
 pepstatin pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens
0.00574
-
 saquinavir pH 5.0, 25°C, 18000 Da enzyme form Homo sapiens