3.4.23.50: human endogenous retrovirus K endopeptidase

This is an abbreviated version!
For detailed information about human endogenous retrovirus K endopeptidase, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

endogenous retrovirus encoded protease, endogenous retrovirus HERV-K10 putative protease, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K(HML-2) Pro, HERV-K(HML-2) protease, HERV-K113 protease, HML-2 Pro, human endogenous retrovirus K retropepsin, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.50 human endogenous retrovirus K endopeptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
103	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
3	Disease/ Diagnostics
1	General Information
31	Inhibitors
40	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
11	Organism
2	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
2	Posttranslational Modification
2	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
11	Reference
16	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
4	Turnover Number [1/s]

KI Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

KI Value on EC 3.4.23.50 - human endogenous retrovirus K endopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Ki Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00006

ABT538

Homo sapiens

-

pH 4.5, 11600 Da core domain

646017

0.00061 - 0.00094

indinavir

2 entries

0.0000046 - 0.000015

KNI227

2 entries

0.00012 - 0.00034

KNI272

2 entries

0.00257 - 0.0049

pepstatin

2 entries

0.0000162 - 0.000061

Q8467

2 entries

0.00113 - 0.00121

ritonavir

2 entries

0.00258 - 0.00574

saquinavir

2 entries

0.0000059 - 0.00003

SD145

2 entries

0.00000015 - 0.0000043

SD146

2 entries

0.0000079 - 0.000027

SD152

2 entries

0.00067 - 0.00187

XK234

2 entries

0.000091 - 0.00039

XM412

2 entries

0.0000022 - 0.00002

XV638

2 entries

0.00000017 - 0.0000039

XV643

2 entries

0.00000022 - 0.0000029

XV644

2 entries

0.0000001 - 0.0000023

XV648

2 entries

0.0000032 - 0.000043

XV651

2 entries

0.00000052 - 0.0000033

XV652

2 entries

0.0000036 - 0.000031

XW805

2 entries

additional information

additional information

Homo sapiens

-

-

646017

-

0.00061

indinavir

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.00094

indinavir

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000046

KNI227

Homo sapiens

-

pH 4.5, 11600 Da core domain

646017

0.000015

KNI227

Homo sapiens

-

pH 4.5, 18200 Da enzyme form

646017

0.00012

KNI272

Homo sapiens

-

pH 4.5, 11600 Da core domain

646017

0.00034

KNI272

Homo sapiens

-

pH 4.5, 18200 Da enzyme form

646017

0.00257

pepstatin

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.0049

pepstatin

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000162

Q8467

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.000061

Q8467

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.00113

ritonavir

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.00121

ritonavir

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.00258

saquinavir

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.00574

saquinavir

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000059

SD145

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.00003

SD145

Homo sapiens

-

pH 5.0, 25°C, 13000 Da enzyme form

646018

0.00000015

SD146

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.0000043

SD146

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000079

SD152

Homo sapiens

-

pH 5.0, 25°C, 13000 Da enzyme form

646018

0.000027

SD152

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.00067

XK234

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.00187

XK234

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.000091

XM412

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.00039

XM412

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000022

XV638

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.00002

XV638

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.00000017

XV643

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.0000039

XV643

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.00000022

XV644

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.0000029

XV644

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000001

XV648

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.0000023

XV648

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000032

XV651

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.000043

XV651

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.00000052

XV652

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.0000033

XV652

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018

0.0000036

XW805

Homo sapiens

-

pH 5.0, 25°C, 13000 Da C-terminally truncated enzyme form

646018

0.000031

XW805

Homo sapiens

-

pH 5.0, 25°C, 18000 Da enzyme form

646018