3.4.23.50: human endogenous retrovirus K endopeptidase
This is an abbreviated version!
For detailed information about human endogenous retrovirus K endopeptidase, go to the full flat file.
Reaction
Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =
Synonyms
endogenous retrovirus encoded protease, endogenous retrovirus HERV-K10 putative protease, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K(HML-2) Pro, HERV-K(HML-2) protease, HERV-K113 protease, HML-2 Pro, human endogenous retrovirus K retropepsin, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin, More
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Engineering
Engineering on EC 3.4.23.50 - human endogenous retrovirus K endopeptidase
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additional information
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a C-terminally truncated mutant enzyme shows increased affinity for the peptide substrates and increased sensitivity to peptidomimetic inhibitors compared to the wild-type enzyme
additional information
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two different, enzymatically inactive mutants of HML-2 Pro harboring mutations in catalytic motifs cannot be purified due to inefficient binding to pepstatin A affinity resin