3.4.23.50: human endogenous retrovirus K endopeptidase

This is an abbreviated version!
For detailed information about human endogenous retrovirus K endopeptidase, go to the full flat file.

Reaction

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-/-PIVQ- cleavage site. =

Synonyms

endogenous retrovirus encoded protease, endogenous retrovirus HERV-K10 putative protease, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K(HML-2) Pro, HERV-K(HML-2) protease, HERV-K113 protease, HML-2 Pro, human endogenous retrovirus K retropepsin, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin, More

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.50 human endogenous retrovirus K endopeptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
103	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
3	Disease/ Diagnostics
1	General Information
31	Inhibitors
40	Ki Value [mM]
4	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
11	Organism
2	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
2	Posttranslational Modification
2	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
11	Reference
16	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
4	Turnover Number [1/s]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 3.4.23.50 - human endogenous retrovirus K endopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Human endogenous retrovirus K

-

hundreds of cellular proteins are potential substrates of enzyme HERV-K(HML-2) Pro. Thus, even low-level expression of HERV-K(HML-2) Pro affects levels of a diverse array of proteins and has a functional impact on cell biology and possible relevance for human diseases

754663