3.4.22.B71: SENP2 peptidase

This is an abbreviated version, for detailed information about SENP2 peptidase, go to the full flat file.


The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO-2 from mitotic kinase Aurora-B. Deconjugates SUMO-1 from Mdm2, an protein critical for genome integrity in P53-dependent stress resüponse. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =


(SUMO-1)-specific protease 2, SENP2, sentrin/SUMO-specific protease 2, small ubiquitin-like modifier-specific protease, small ubiquitin-like modifier-specific protease 2, small ubiquitin-related modifier-specific isopeptidase, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 2


     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B71 SENP2 peptidase