3.4.22.B71: SENP2 peptidase
This is an abbreviated version!
For detailed information about SENP2 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B71
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3.4.22.B71
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sumoylation
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medicine
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atherosclerosis
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aorta
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d-flow
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d-flow-induced
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erk5
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de-sumoylation
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p90rsk
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senps
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epilepsy
- 3.4.22.B71
-
sumoylation
- medicine
- atherosclerosis
-
aorta
-
d-flow
-
d-flow-induced
- erk5
-
de-sumoylation
-
p90rsk
-
senps
-
epilepsy
Reaction
=
Synonyms
(SUMO-1)-specific protease 2, SENP2, sentrin/SUMO-specific protease 2, small ubiquitin-like modifier-specific protease, small ubiquitin-like modifier-specific protease 2, small ubiquitin-related modifier-specific isopeptidase, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 2
ECTree
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Localization
Localization on EC 3.4.22.B71 - SENP2 peptidase
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SENP2 shuttles between the nucleus and the cytoplasm. Identification of a bipartite nuclear localization signal and a CRM1-dependent nuclear export signal in the SUMO protease SENP2. Nucleocytoplasmic shuttling is a crucial regulatory mechanism for SENP2 function
SENP2 associates with the nuclear face of nuclear pores. This association requires protein sequences near the N-terminus of SENP2. Association with the pore plays an important negative role in the regulation of SENP2, perhaps by restricting its activity to a subset of the conjugated proteins within the nucleus
the enzyme SENP2 is targeted to kinetochores in mitosis. SENP2 targeting occurs through a mechanism dependent on the Nup107-160 subcomplex of the nuclear pore complex and is modulated through interactions with karyopherin alpha