3.4.22.B71: SENP2 peptidase

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For detailed information about SENP2 peptidase, go to the full flat file.

Reaction

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Synonyms

(SUMO-1)-specific protease 2, SENP2, sentrin/SUMO-specific protease 2, small ubiquitin-like modifier-specific protease, small ubiquitin-like modifier-specific protease 2, small ubiquitin-related modifier-specific isopeptidase, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B71 SENP2 peptidase

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Results	in table
1	Activating Compound
2	AA Sequence
4	Application
6	Cloned(Commentary)
3	Crystallization (Commentary)
5	Disease/ Diagnostics
4	Expression
37	General Information
5	kcat/KM [mM/s]
5	KM Value [mM]
9	Localization
9	Natural Substrates/ Products (Substrates)
167	Organism
4	pH Optimum
1	Posttranslational Modification
16	Protein Variants
4	Purification (Commentary)
1	Reaction
28	Reference
37	Source Tissue
37	Substrates and Products (Substrate)
26	Synonyms
4	Temperature Optimum [°C]
5	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.22.B71 - SENP2 peptidase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

recombinant chimeric mutant SENP2 C548S-loop1 in complex with SUMO2, X-ray diffraction structure determination and analysis at 2.15 A resolution

Homo sapiens

Q9HC62

732884

Senp2 crystallization is performed at 4°C using sitting and hanging drop vapor diffusion methods. X-ray structures of Senp2 catalytic protease domain and of a covalent thiohemiacetal transition-state complex obtained between the Senp2 catalytic domain and SUMO-1 reveales details of the respective protease and substrate surfaces utilized in interactions between these two proteins. Comparative biochemical and structural analysis between Senp2 and the yeast SUMO protease Ulp1 reveales differential abilities to process SUMO-1, SUMO-2, and SUMO-3 in maturation and deconjugation reactions

Homo sapiens

Q9HC62

716931

X-ray structures are determined for a catalytically inert SENP2 protease domain in complex with conjugated RanGAP1-SUMO-1 or RanGAP1-SUMO-2, or in complex with SUMO-2 or SUMO-3 precursors

Homo sapiens

Q9HC62

682080