3.4.22.B71: SENP2 peptidase

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For detailed information about SENP2 peptidase, go to the full flat file.

Reaction

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Synonyms

(SUMO-1)-specific protease 2, SENP2, sentrin/SUMO-specific protease 2, small ubiquitin-like modifier-specific protease, small ubiquitin-like modifier-specific protease 2, small ubiquitin-related modifier-specific isopeptidase, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B71 SENP2 peptidase

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Results	in table
1	Activating Compound
2	AA Sequence
4	Application
6	Cloned(Commentary)
3	Crystallization (Commentary)
5	Disease/ Diagnostics
4	Expression
37	General Information
5	kcat/KM [mM/s]
5	KM Value [mM]
9	Localization
9	Natural Substrates/ Products (Substrates)
167	Organism
4	pH Optimum
1	Posttranslational Modification
16	Protein Variants
4	Purification (Commentary)
1	Reaction
28	Reference
37	Source Tissue
37	Substrates and Products (Substrate)
26	Synonyms
4	Temperature Optimum [°C]
5	Turnover Number [1/s]

Expression

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Expression on EC 3.4.22.B71 - SENP2 peptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

in C2C12 myotubes, treatment with saturated fatty acids, like palmitate, leads to nuclear factor-kappaB-mediated increase in the expression of SENP2

Mus musculus

-

731703

leptin treatment of C2C12 myotubes causes STAT3 to bind to the Senp2 promoter, inducing SENP2 expression

Mus musculus

Q91ZX6

754620

SENP2 expression is markedly increased upon the induction of adipocyte differentiation, and this increase is dependent on protein kinase A activation. Elevated cAMP level induces SENP2 expression through cyclic AMP response element-binding protein (CREB) binding to a functional cis-acting cAMP response element (CRE) in the SENP2 promoter

Mus musculus

Q91ZX6

716210

the SENP2 level is not sensitive to changes in nucleoporin Nup153 abundance

Homo sapiens

-

732590