3.4.22.B71: SENP2 peptidase

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For detailed information about SENP2 peptidase, go to the full flat file.

Reaction

=

Synonyms

(SUMO-1)-specific protease 2, SENP2, sentrin/SUMO-specific protease 2, small ubiquitin-like modifier-specific protease, small ubiquitin-like modifier-specific protease 2, small ubiquitin-related modifier-specific isopeptidase, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B71 SENP2 peptidase

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Results	in table
1	Activating Compound
2	AA Sequence
4	Application
6	Cloned(Commentary)
3	Crystallization (Commentary)
5	Disease/ Diagnostics
4	Expression
37	General Information
5	kcat/KM [mM/s]
5	KM Value [mM]
9	Localization
9	Natural Substrates/ Products (Substrates)
167	Organism
4	pH Optimum
1	Posttranslational Modification
16	Protein Variants
4	Purification (Commentary)
1	Reaction
28	Reference
37	Source Tissue
37	Substrates and Products (Substrate)
26	Synonyms
4	Temperature Optimum [°C]
5	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.4.22.B71 - SENP2 peptidase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

ubiquitination

Homo sapiens

Q9HC62

SENP2 can be polyubiquitinated in vivo and degraded through proteolysis. Restricting SENP2 in the nucleus by mutations in the nuclear export signal (NES) impairs its polyubiquitination, whereas a cytoplasm-localized SENP2 made by introducing mutations in the nuclear localization signal (NLS) can be efficiently polyubiquitinated, suggesting that SENP2 is ubiquitinated in the cytoplasm

681909