3.4.22.B71: SENP2 peptidase

This is an abbreviated version!
For detailed information about SENP2 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B71

3.4.22.B71

sumoylation

medicine

atherosclerosis

aorta

d-flow

d-flow-induced

erk5

de-sumoylation

p90rsk

senps

epilepsy

Reaction

Synonyms

(SUMO-1)-specific protease 2, SENP2, sentrin/SUMO-specific protease 2, small ubiquitin-like modifier-specific protease, small ubiquitin-like modifier-specific protease 2, small ubiquitin-related modifier-specific isopeptidase, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B71 SENP2 peptidase

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Results	in table
1	Activating Compound
2	AA Sequence
4	Application
6	Cloned(Commentary)
3	Crystallization (Commentary)
5	Disease/ Diagnostics
4	Expression
37	General Information
5	kcat/KM [mM/s]
5	KM Value [mM]
9	Localization
9	Natural Substrates/ Products (Substrates)
167	Organism
4	pH Optimum
1	Posttranslational Modification
16	Protein Variants
4	Purification (Commentary)
1	Reaction
28	Reference
37	Source Tissue
37	Substrates and Products (Substrate)
26	Synonyms
4	Temperature Optimum [°C]
5	Turnover Number [1/s]

Reaction

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Reaction on EC 3.4.22.B71 - SENP2 peptidase

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The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO-2 from mitotic kinase Aurora-B. Deconjugates SUMO-1 from Mdm2, an protein critical for genome integrity in P53-dependent stress resüponse. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe.