3.4.22.B5: CPB protease

This is an abbreviated version!
For detailed information about CPB protease, go to the full flat file.

Reaction

good cleavage of the Arg-Phe bond. The best substrate ortho-aminobenzoyl-KLR-/-FSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) is also well hydrolyzed by cathepsin L, however the best inhibitor of the parasite enzyme ortho-aminobenzoyl-KLRFSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) has low affinity to cathepsin L =

Synonyms

C01.074, CPB, cpb-like, CPB1, CPB10, CPB11, CPB12, CPB13, CPB14, CPB15, CPB16, CPB17, CPB18, CPB19, CPB2, CPB2.3, CPB2.8, CPB3, CPB3.0, CPB4, CPB5, CPB6, CPB7, CPB8, CPB9, cystein protease CPB2.8, cysteine peptidase, cysteine peptidase B, cysteine protease B, cysteine protease CPB, cysteine proteinase B, cysteine proteinase type I, cysteine-proteinase B, LBRM_08_0810, LBRM_08_0820, LBRM_08_0830, LdcCys1, type I cysteine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B5 CPB protease

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Results	in table
3	Activating Compound
11	AA Sequence
10	Application
1	CAS Registry Number
9	Cloned(Commentary)
10	General Information
27	IC50 Value
89	Inhibitors
55	Ki Value [mM]
82	KM Value [mM]
9	Localization
6	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
59	Organism
4	pH Optimum
3	pH Range
2	pH Stability
4	pI Value
1	Posttranslational Modification
4	Protein Variants
10	Purification (Commentary)
1	Reaction
2	Reaction Type
50	Reference
17	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
124	Substrates and Products (Substrate)
3	Subunits
85	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
80	Turnover Number [1/s]

pI Value

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pI Value on EC 3.4.22.B5 - CPB protease

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pI VALUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4.34

Leishmania mexicana

P36400

isoenzyme CPB1

647698

4.37

Leishmania mexicana

P36400

isoenzyme CPB19

647698

4.83

Leishmania mexicana

P36400

isoenzyme CPB2.8

647698

5.4

Leishmania mexicana

P36400

isoenzyme CPB18

647698