3.4.22.B5: CPB protease

This is an abbreviated version!
For detailed information about CPB protease, go to the full flat file.

Reaction

good cleavage of the Arg-Phe bond. The best substrate ortho-aminobenzoyl-KLR-/-FSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) is also well hydrolyzed by cathepsin L, however the best inhibitor of the parasite enzyme ortho-aminobenzoyl-KLRFSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) has low affinity to cathepsin L =

Synonyms

C01.074, CPB, cpb-like, CPB1, CPB10, CPB11, CPB12, CPB13, CPB14, CPB15, CPB16, CPB17, CPB18, CPB19, CPB2, CPB2.3, CPB2.8, CPB3, CPB3.0, CPB4, CPB5, CPB6, CPB7, CPB8, CPB9, cystein protease CPB2.8, cysteine peptidase, cysteine peptidase B, cysteine protease B, cysteine protease CPB, cysteine proteinase B, cysteine proteinase type I, cysteine-proteinase B, LBRM_08_0810, LBRM_08_0820, LBRM_08_0830, LdcCys1, type I cysteine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B5 CPB protease

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Results	in table
3	Activating Compound
11	AA Sequence
10	Application
1	CAS Registry Number
9	Cloned(Commentary)
10	General Information
27	IC50 Value
89	Inhibitors
55	Ki Value [mM]
82	KM Value [mM]
9	Localization
6	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
59	Organism
4	pH Optimum
3	pH Range
2	pH Stability
4	pI Value
1	Posttranslational Modification
4	Protein Variants
10	Purification (Commentary)
1	Reaction
2	Reaction Type
50	Reference
17	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
124	Substrates and Products (Substrate)
3	Subunits
85	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
80	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.22.B5 - CPB protease

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

additional information

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2 entries

additional information

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Leishmania mexicana

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the very high soluble proteinase activity of Leishmania mexicana amastigoes may be a primary factor in the survival and growth of this mammalian stage in its potentially degradative intracellular habitat

647699

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additional information

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Leishmania mexicana

P36400

individual isoenzymes have distinct roles in the parasite‘s interaction with its host

647698

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