3.4.22.B5: CPB protease

This is an abbreviated version!
For detailed information about CPB protease, go to the full flat file.

Reaction

good cleavage of the Arg-Phe bond. The best substrate ortho-aminobenzoyl-KLR-/-FSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) is also well hydrolyzed by cathepsin L, however the best inhibitor of the parasite enzyme ortho-aminobenzoyl-KLRFSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) has low affinity to cathepsin L =

Synonyms

C01.074, CPB, cpb-like, CPB1, CPB10, CPB11, CPB12, CPB13, CPB14, CPB15, CPB16, CPB17, CPB18, CPB19, CPB2, CPB2.3, CPB2.8, CPB3, CPB3.0, CPB4, CPB5, CPB6, CPB7, CPB8, CPB9, cystein protease CPB2.8, cysteine peptidase, cysteine peptidase B, cysteine protease B, cysteine protease CPB, cysteine proteinase B, cysteine proteinase type I, cysteine-proteinase B, LBRM_08_0810, LBRM_08_0820, LBRM_08_0830, LdcCys1, type I cysteine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B5 CPB protease

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Results	in table
3	Activating Compound
11	AA Sequence
10	Application
1	CAS Registry Number
9	Cloned(Commentary)
10	General Information
27	IC50 Value
89	Inhibitors
55	Ki Value [mM]
82	KM Value [mM]
9	Localization
6	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
59	Organism
4	pH Optimum
3	pH Range
2	pH Stability
4	pI Value
1	Posttranslational Modification
4	Protein Variants
10	Purification (Commentary)
1	Reaction
2	Reaction Type
50	Reference
17	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
124	Substrates and Products (Substrate)
3	Subunits
85	Synonyms
3	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
80	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.22.B5 - CPB protease

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00007

(2(1H)-pyridinethionato-kappaS2)[2,6-bis[(mercapto-KappaS)methyl]pyridine-kappaN1] oxorhenium(V)

Leishmania major

-

-

699388

0.01

(methanethiolato)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium (V)

Leishmania major

-

above 0.01 mM

699388

0.001

(p-methoxyphenylthiolato-S)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)

Leishmania major

-

-

699388

0.00006

2-phenyl-1H-indole-3-carbaldehyde thiosemicarbazone

Leishmania mexicana

-

truncated enzyme mutant CPB2.8DEKTACTE, pH 7.4, 22°C

732753

0.00001

3-[(1H-benzimidazol-2-yl)-2H-1-benzopyran-2-ylidene]-2-carbaldehyde semicarbazone

Leishmania mexicana

-

truncated enzyme mutant CPB2.8DEKTACTE, pH 7.4, 22°C

732753

0.0011

4-(cyclohexylamino)-6-[(2-methoxy-3-pyridinyl)amino]-1,3,5-triazine-2-carbonitrile

Leishmania mexicana

-

truncated enzyme mutant CPB2.8DEKTACTE, pH 7.4, 22°C

732753

0.00023

4-methyl N-[(S)-1-oxo-1-[(S)-1-oxo-4-phenyl-1-(5-phenylisoxazol-3-yl)butan-2-ylamino]-3-phenylpropan-2-yl]piperazine-1-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00007

5-(4-methoxy-phenyl)-2-furanyl-2-carbaldehyde thiosemicarbazone

Leishmania mexicana

-

truncated enzyme mutant CPB2.8DEKTACTE, pH 7.4, 22°C

732753

0.0021

aceto[2,6-bis[(butylthio-jS)methyl]phenyl-kappaC]-,(SP-4-3)-palladium(II)

Leishmania major

-

-

699388

0.0002

chloro[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)

Leishmania major

-

-

699388

0.0017

diaceto[2-[(2-pyridinyl-kappaN)methyl]-phenyl-kappaC]Au(III)-,(SP-4-3)

Leishmania major

-

-

699388

0.0529

N-((S)-1-[(S)-1-[1-(benzyloxymethyl)-1H-1,2,3-triazol-4-yl]-1-oxo-3-phenylpropan-2-ylamino]-1-oxo-3-phenylpropan-2-yl)morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00005

N-[(2S)-1-[(2S)-1-hydroxy-3-phenyl-1-(5-phenyl-1,2,4-oxadiazol-3-yl)propan-2-ylamino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00044

N-[(S)-1-oxo-1-[(S)-1-oxo-3-phenyl-1-(1-phenyl-1H-1,2,3-triazol-4-yl)propan-2-ylamino]-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

one of two purified isomers, pH 5.0 30°C

708125

0.0015

N-[(S)-1-oxo-1-[(S)-1-oxo-3-phenyl-1-(3-phenylisoxazol-5-yl)propan-2-ylamino]-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00013

N-[(S)-1-oxo-1-[(S)-1-oxo-3-phenyl-1-(5-phenylisoxazol-3-yl)propan-2-ylamino]-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

one of two purified isomers, pH 5.0 30°C

708125

0.00047

N-[(S)-1-oxo-1-[(S)-1-oxo-3-phenyl-1-(5-phenyloxazol-2-yl)propan-2-ylamino]-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.01294

N-[(S)-1-oxo-1-[(S)-1-oxo-3-phenyl-1-(5-phenylthiazol-2-yl)propan-2-ylamino]-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00366

N-[(S)-1-[(d)-1-(5-benzylisoxazol-3-yl)-1-oxo-4-phenylbutan-2-ylamino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00355

N-[(S)-1-[(S)-1-(benzo[d]oxazol-2-yl)-1-oxo-3-phenylpropan-2-ylamino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.02379

N-[(S)-1-[(S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-phenylpropan-2-ylamino]-1-oxo-3-phenylpropan-2-yl]morpholine-4-carboxamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00245

N-[1-(4'-chloro-5-hydroxy-3-oxo[1,2,3,6-tetrahydro[1,1'-biphenyl]]-4-yl)-1-oxopropan-2-yl]benzamide

Leishmania mexicana

P36400

recombinant form of the amastigote-specific isoform CPB2.8 without the C-terminal extension, pH not specified in the publication, temperature not specified in the publication

753241

0.000027

Nalpha-(morpholin-4-ylcarbonyl)-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-phenylalaninamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.00019

Nalpha-(morpholin-4-ylcarbonyl)-N-[(2S)-1-oxo-4-phenyl-1-(5-phenyl-1,2-oxazol-3-yl)butan-2-yl]-L-phenylalaninamide

Leishmania mexicana

-

one of two purified isomers, pH 5.0 30°C

708125

0.000054

Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]-L-phenylalaninamide

Leishmania mexicana

-

pH 5.0 30°C

708125

0.0029 - 0.0043

[2-hydroxy-4-(2-methylpropoxy)phenyl](4-hydroxyphenyl)methanone

2 entries

0.0029

[2-hydroxy-4-(2-methylpropoxy)phenyl](4-hydroxyphenyl)methanone

Leishmania mexicana

P36400

isoform CPB2.8, pH 5.5, 37°C

752915

0.0043

[2-hydroxy-4-(2-methylpropoxy)phenyl](4-hydroxyphenyl)methanone

Leishmania mexicana

P36400

isoform CPB3.0, pH 5.5, 37°C

752915