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3.4.22.B5: CPB protease

This is an abbreviated version!
For detailed information about CPB protease, go to the full flat file.

Word Map on EC 3.4.22.B5

Reaction

good cleavage of the Arg-Phe bond. The best substrate ortho-aminobenzoyl-KLR-/-FSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) is also well hydrolyzed by cathepsin L, however the best inhibitor of the parasite enzyme ortho-aminobenzoyl-KLRFSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) has low affinity to cathepsin L =

Synonyms

C01.074, CPB, cpb-like, CPB1, CPB10, CPB11, CPB12, CPB13, CPB14, CPB15, CPB16, CPB17, CPB18, CPB19, CPB2, CPB2.3, CPB2.8, CPB3, CPB3.0, CPB4, CPB5, CPB6, CPB7, CPB8, CPB9, cystein protease CPB2.8, cysteine peptidase, cysteine peptidase B, cysteine protease B, cysteine protease CPB, cysteine proteinase B, cysteine proteinase type I, cysteine-proteinase B, LBRM_08_0810, LBRM_08_0820, LBRM_08_0830, LdcCys1, type I cysteine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B5 CPB protease

Reference

Reference on EC 3.4.22.B5 - CPB protease

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Alves, L.C.; Melo, R.L.; Cezari, M.H.S.; Sanderson, S.J.; Mottram, J.C.; Coombs, G.H.; Juliano, L.; Juliano, M.A.
Analysis of the S2 subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids
Mol. Biochem. Parasitol.
117
137-143
2001
Leishmania mexicana
Manually annotated by BRENDA team
Alves, L.C.; Judice, W.A.S.; St.Hilaire, P.M.; Meldal, M.; Sanderson, S.J.; Mottram, J.C.; Coombs, G.H.; Juliano, L.; Juliano, M.A.
Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana
Mol. Biochem. Parasitol.
116
1-9
2001
Leishmania mexicana
Manually annotated by BRENDA team
Alves, L.C.; St.Hilaire, P.M.; Meldal, M.; Sanderson, S.J.; Mottram, J.C.; Coombs, G.H.; Juliano, L.; Juliano, M.A.
Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana
Mol. Biochem. Parasitol.
114
81-88
2001
Leishmania mexicana
Manually annotated by BRENDA team
Souza, A.E.; Waugh, S.; Coombs, G.H.; Mottram, J.C.
Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana
FEBS Lett.
311
124-127
1992
Leishmania mexicana (P36400)
Manually annotated by BRENDA team
Mottram, J.C.; Frame, M.J.; Brooks, D.R.; Tetley, L.; Hutchison, J.E.; Souza, A.E.; Coombs, G.H.
The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences
J. Biol. Chem.
272
14285-14293
1997
Leishmania mexicana (P36400)
Manually annotated by BRENDA team
Coombs, G.H.
Proteinases of Leishmania mexicana and other flagellate protozoa
Parasitology
84
149-155
1982
Leishmania mexicana
Manually annotated by BRENDA team
Sanderson, S.J.; Pollock, K.G.J.; Hilley, J.D.; et al.
Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana
Biochem. J.
347
383-388
2000
Leishmania mexicana
Manually annotated by BRENDA team
Judice, W.A.; Puzer, L.; Cotrin, S.S.; Carmona, A.K.; Coombs, G.H.; Juliano, L.; Juliano, M.A.
Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana
Eur. J. Biochem.
271
1046-1053
2004
Leishmania mexicana
Manually annotated by BRENDA team
Juliano, M.A.; Brooks, D.R.; Selzer, P.M.; Pandolfo, H.L.; Judice, W.A.; Juliano, L.; Meldal, M.; Sanderson, S.J.; Mottram, J.C.; Coombs, G.H.
Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes
Eur. J. Biochem.
271
3704-3714
2004
Leishmania mexicana, Leishmania mexicana MNYC/BZ/M379
Manually annotated by BRENDA team
Mottram, J.C.; Coombs, G.H.
Leishmania CPA, CPB and CPC cysteine proteases
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press
2
1166-1169
2004
Leishmania mexicana
-
Manually annotated by BRENDA team
Cameron, P.; McGachy, A.; Anderson, M.; Paul, A.; Coombs, G.H.; Mottram, J.C.; Alexander, J.; Plevin, R.
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway
J. Immunol.
173
3297-3304
2004
Leishmania mexicana, Leishmania mexicana MYNC/BZ/62/M379
Manually annotated by BRENDA team
Judice, W.A.; Mottram, J.C.; Coombs, G.H.; Juliano, M.A.; Juliano, L.
Specific negative charges in cysteine protease isoforms of Leishmania mexicana are highly influential on the substrate binding and hydrolysis
Mol. Biochem. Parasitol.
144
36-43
2005
Leishmania mexicana
Manually annotated by BRENDA team
Zadeh-Vakili, A.; Taheri, T.; Taslimi, Y.; Doustdari, F.; Salmanian, A.H.; Rafati, S.
Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis
Vaccine
22
1930-1940
2004
Leishmania major, Leishmania major MRHO/IR/75/ER
Manually annotated by BRENDA team
Hide, M.; Bras-Goncalves, R.; Banuls, A.L.
Specific cpb copies within the Leishmania donovani complex: evolutionary interpretations and potential clinical implications in humans
Parasitology
134
379-389
2007
Leishmania donovani, Leishmania infantum
Manually annotated by BRENDA team
Lanfranco, M.F.; Loayza-Muro, R.; Clark, D.; Nunez, R.; Zavaleta, A.I.; Jimenez, M.; Meldal, M.; Coombs, G.H.; Mottram, J.C.; Izidoro, M.; Juliano, M.A.; Juliano, L.; Arevalo, J.
Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis
Mol. Biochem. Parasitol.
161
91-100
2008
Leishmania braziliensis
Manually annotated by BRENDA team
Pinheiro, P.H.; Pinheiro, A.N.; Ferreira, J.H.; Costa, F.A.; Katz, S.; Barbieri, C.L.
A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi as an antigen for delayed-type hypersensitivity assays and serodiagnosis of canine visceral leishmaniasis.
Vet. Parasitol.
162
32-39
2009
Leishmania chagasi
Manually annotated by BRENDA team
Elias, C.G.; Pereira, F.M.; Dias, F.A.; Silva, T.L.; Lopes, A.H.; dAvila-Levy, C.M.; Branquinha, M.H.; Santos, A.L.
Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment
Exp. Parasitol.
120
343-352
2008
Phytomonas serpens
Manually annotated by BRENDA team
Fricker, S.P.; Mosi, R.M.; Cameron, B.R.; Baird, I.; Zhu, Y.; Anastassov, V.; Cox, J.; Doyle, P.S.; Hansell, E.; Lau, G.; Langille, J.; Olsen, M.; Qin, L.; Skerlj, R.; Wong, R.S.; Santucci, Z.; McKerrow, J.H.
Metal compounds for the treatment of parasitic diseases
J. Inorg. Biochem.
102
1839-1845
2008
Leishmania major
Manually annotated by BRENDA team
Pereira, F.M.; Elias, C.G.; dAvila-Levy, C.M.; Branquinha, M.H.; Santos, A.L.
Cysteine peptidases in Herpetomonas samuelpessoai are modulated by temperature and dimethylsulfoxide-triggered differentiation
Parasitology
136
45-54
2009
Herpetomonas pessoai, Leishmania amazonensis, Herpetomonas pessoai CT-IOC-067, Leishmania amazonensis MHOM/BR/75/Josefa
Manually annotated by BRENDA team
Steert, K.; Berg, M.; Mottram, J.C.; Westrop, G.D.; Coombs, G.H.; Cos, P.; Maes, L.; Joossens, J.; Van der Veken, P.; Haemers, A.; Augustyns, K.
alpha-Ketoheterocycles as Inhibitors of Leishmania mexicana Cysteine Protease CPB
ChemMedChem
5
1734-1748
2010
Leishmania mexicana
Manually annotated by BRENDA team
Laurent, T.; Van der Auwera, G.; Hide, M.; Mertens, P.; Quispe-Tintaya, W.; Deborggraeve, S.; De Doncker, S.; Leclipteux, T.; Banuls, A.; Buescher, P.; Dujardin, J.
Identification of Old World Leishmania spp. by specific polymerase chain reaction amplification of cysteine proteinase B genes and rapid dipstick detection
Diagn. Microbiol. Infect. Dis.
63
173-181
2009
Leishmania donovani, Leishmania infantum, Leishmania major, Leishmania aethiopica (Q0ZKZ3), Leishmania aethiopica (Q0ZKZ4), Leishmania aethiopica (Q0ZKZ5), Leishmania aethiopica, Leishmania tropica (Q0ZKZ6), Leishmania tropica (Q0ZKZ7), Leishmania tropica (Q0ZKZ8), Leishmania tropica (Q0ZKZ9), Leishmania tropica
Manually annotated by BRENDA team
Rebello, K.; Cortes, L.; Pereira, B.; Pascarelli, B.; Corte-Real, S.; Finkelstein, L.; Pinho, R.; d'Avila-Levy, C.; Alves, C.
Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis
Parasitol. Res.
106
95-104
2009
Leishmania braziliensis
Manually annotated by BRENDA team
Pereira, B.A.; Silva, F.S.; Rebello, K.M.; Marin-Villa, M.; Traub-Cseko, Y.M.; Andrade, T.C.; Bertho, A.L.; Caffarena, E.R.; Alves, C.R.
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection
BMC Immunol.
12
44
2011
Leishmania amazonensis, Leishmania amazonensis MHOM/BR/77 / LTB0016
Manually annotated by BRENDA team
Schroeder, J.; Noack, S.; Marhoefer, R.J.; Mottram, J.C.; Coombs, G.H.; Selzer, P.M.
Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB
PLoS ONE
8
e77460
2013
Leishmania mexicana
Manually annotated by BRENDA team
Gomes, C.B.; -Silva, F.S.; Charret, K.D.; Pereira, B.A.; Finkelstein, L.C.; Santos-de-Souza, R.; de Castro Cortes, L.M.; Pereira, M.C.; Rodrigues de Oliveira, F.O.; Alves, C.R.
Increasing in cysteine proteinase B expression and enzymatic activity during invitro differentiation of Leishmania (Viannia) braziliensis First evidence of modulation during morphological transition
Biochimie
133
28-36
2017
Leishmania braziliensis (A4H5E4), Leishmania braziliensis (A4H5E5), Leishmania braziliensis (A4H5E6), Leishmania braziliensis, Leishmania braziliensis R619 (A4H5E4), Leishmania braziliensis R619 (A4H5E5), Leishmania braziliensis R619 (A4H5E6)
Manually annotated by BRENDA team
de Almeida, L.; Alves, K.F.; Maciel-Rezende, C.M.; Jesus, L.d.e. .O.; Pires, F.R.; Junior, C.V.; Izidoro, M.A.; Judice, W.A.; dos Santos, M.H.; Marques, M.J.
Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes
Biomed. Pharmacother.
75
93-99
2015
Leishmania mexicana (P36400)
Manually annotated by BRENDA team
Scala, A.; Rescifina, A.; Micale, N.; Piperno, A.; Schirmeister, T.; Maes, L.; Grassi, G.
Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8DELTACTE
Chem. Biol. Drug Des.
91
597-604
2018
Leishmania mexicana (P36400)
Manually annotated by BRENDA team
Noormehr, H.; Zavaran Hosseini, A.; Soudi, S.; Beyzay, F.
Enhancement of Th1 immune response against Leishmania cysteine peptidase A, B by PLGA nanoparticle
Int. Immunopharmacol.
59
97-105
2018
Leishmania major
Manually annotated by BRENDA team
Santos, D.A.; de Souza Costa, M.G.; Alves, C.R.; Caffarena, E.R.
Structural and dynamic insights into the C-terminal extension of cysteine proteinase B from Leishmania amazonensis
J. Mol. Graph. Model.
70
30-39
2016
Leishmania amazonensis
Manually annotated by BRENDA team
Santos-de-Souza, R.; Souza-Silva, F.; de Albuquerque-Melo, B.C.; Ribeiro-Guimaraes, M.L.; de Castro Cortes, L.M.; Pereira, B.A.S.; Silva-Almeida, M.; Cysne-Finkelstein, L.; de Oliveira Junior, F.O.R.; Pereira, M.C.S.; Alves, C.R.
Insights into the tracking of the cysteine proteinase B COOH-terminal polypeptide of Leishmania (Leishmania) amazonensis by surface plasmon resonance
Parasitol. Res.
118
1249-1259
2019
Leishmania amazonensis, Leishmania amazonensis LTB0016
Manually annotated by BRENDA team
Casgrain, P.A.; Martel, C.; McMaster, W.R.; Mottram, J.C.; Olivier, M.; Descoteaux, A.
Cysteine peptidase B regulates Leishmania mexicana virulence through the modulation of GP63 expression
PLoS Pathog.
12
e1005658
2016
Leishmania mexicana (P36400), Leishmania mexicana, Leishmania mexicana M379 (P36400)
Manually annotated by BRENDA team