3.4.22.B5: CPB protease
This is an abbreviated version!
For detailed information about CPB protease, go to the full flat file.
Reaction
good cleavage of the Arg-Phe bond. The best substrate ortho-aminobenzoyl-KLR-/-FSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) is also well hydrolyzed by cathepsin L, however the best inhibitor of the parasite enzyme ortho-aminobenzoyl-KLRFSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) has low affinity to cathepsin L
=
Synonyms
C01.074, CPB, cpb-like, CPB1, CPB10, CPB11, CPB12, CPB13, CPB14, CPB15, CPB16, CPB17, CPB18, CPB19, CPB2, CPB2.3, CPB2.8, CPB3, CPB3.0, CPB4, CPB5, CPB6, CPB7, CPB8, CPB9, cystein protease CPB2.8, cysteine peptidase, cysteine peptidase B, cysteine protease B, cysteine protease CPB, cysteine proteinase B, cysteine proteinase type I, cysteine-proteinase B, LBRM_08_0810, LBRM_08_0820, LBRM_08_0830, LdcCys1, type I cysteine protease
ECTree
Application
Application on EC 3.4.22.B5 - CPB protease
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medicine
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amastigote-specific cysteine peptidases of Leishmania mexicana are central to the ability of the parasite to modulate signaling vie NF-kapaB and consequently inhibit IL-12 production by mouse bone marrow-derived macrophages
medicine
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CPB isoenzymes with a few negative charge modifications provide the parasite with an array of hydrolytic activity and enzymatic adaptation to pH, salinity, and temperature that may be needed for its interaction with the mammalian host
medicine
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large preference for Pro in the P2' position for the hydrolytic activity of CPB3, which may be relevant to a role in the activation mechanism of th Leishmania mexicana
medicine
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Leishmanial cysteine protease is implicated in modulation of the host immune system to favor parasite survival and proliferation, the enzyme has vaccine potential and is involved in effecting a cell death process in the parasite
medicine
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the hybrid CPA/B is able to elicit a protective immune response against Leishmania major in the mice model
medicine
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Leishmania chagasi recombinant cysteine proteinase is potentially useful for diagnosis of canine visceral leishmaniasis, as well as for the discrimination of clinical and subclinical forms of the disease
medicine
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coupling of CPB and CPA to nanoparticles in combination with coupling of poly D,L-lactide-co-glycolic acid enhances Th1 immune response. Immunization of mice leads to significant induction of nitric oxide production by peritoneal macrophages and increase in splenocyte IFN-gamma production
medicine
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the hybrid CPA/B is able to elicit a protective immune response against Leishmania major in the mice model
-
medicine
-
amastigote-specific cysteine peptidases of Leishmania mexicana are central to the ability of the parasite to modulate signaling vie NF-kapaB and consequently inhibit IL-12 production by mouse bone marrow-derived macrophages
-
medicine
-
large preference for Pro in the P2' position for the hydrolytic activity of CPB3, which may be relevant to a role in the activation mechanism of th Leishmania mexicana
-