3.4.22.56: caspase-3

This is an abbreviated version!
For detailed information about caspase-3, go to the full flat file.

Word Map on EC 3.4.22.56

3.4.22.56

bcl-2

caspase-9

necrosis

tunel

parp

anti-apoptotic

neuroprotective

pro-apoptotic

tnf

endothelial

annexin

leukemia

apoptosis-related

mapks

fas

ischemia

dismutase

deoxynucleotidyl

erk

neurotoxicity

artery

cyclin

cerebral

dutp

malondialdehyde

reperfusion

infarct

nick

cardiac

sirna

apoptosis-inducing

myocardial

gsh

cardiomyocytes

sham

c-jun

cisplatin

survivin

transferase-mediated

iodide

hippocampal

adp-ribose

hoechst

antiproliferative

caspase-dependent

polyadp-ribose

bid

ischemia-reperfusion

propidium

ladder

analysis

drug development

molecular biology

medicine

diagnostics

Reaction

strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-/- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position =

Synonyms

apopain, C14.003, Cas-3, CASP-3, CASP3, caspase 3, caspase-3, CgCaspase-3, CPP-32, CPP32, CPP32/apopain, cystein aspartic-specific protease-3, cysteine aspartic acid-specific protease, cysteine protease CPP32, DEVDase, IRP, Lyccasp3, Mncaspase-3c, More, SBTc-3, SCA-1, SREBP cleavage activity 1, Yama protein, Yama/CPP32, ZCASP3

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.56 caspase-3

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Results	in table
66	Activating Compound
31	AA Sequence
22	Application
1	CAS Registry Number
26	Cloned(Commentary)
8	Crystallization (Commentary)
28513	Disease/ Diagnostics
15	Expression
20	General Information
237	IC50 Value
514	Inhibitors
11	kcat/KM [mM/s]
79	Ki Value [mM]
53	KM Value [mM]
19	Localization
9	Molecular Weight [Da]
104	Natural Substrates/ Products (Substrates)
423	Organism
208	PDB ID
26	pH Optimum
1	pI Value
26	Posttranslational Modification
15	Protein Variants
13	Purification (Commentary)
2	Reaction
1	Reaction Type
212	Reference
305	Source Tissue
9	Specific Activity [micromol/min/mg]
266	Substrates and Products (Substrate)
10	Subunits
48	Synonyms
28	Temperature Optimum [°C]
35	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.22.56 - caspase-3

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Q08DY9 pBLAST

CASP3_BOVIN

Bos taurus

275

31136

Swiss-Prot