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3.4.22.56: caspase-3

This is an abbreviated version!
For detailed information about caspase-3, go to the full flat file.

Word Map on EC 3.4.22.56

Reaction

strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-/- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position =

Synonyms

apopain, C14.003, Cas-3, CASP-3, CASP3, caspase 3, caspase-3, CgCaspase-3, CPP-32, CPP32, CPP32/apopain, cystein aspartic-specific protease-3, cysteine aspartic acid-specific protease, cysteine protease CPP32, DEVDase, IRP, Lyccasp3, Mncaspase-3c, More, SBTc-3, SCA-1, SREBP cleavage activity 1, Yama protein, Yama/CPP32, ZCASP3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.56 caspase-3

Molecular Weight

Molecular Weight on EC 3.4.22.56 - caspase-3

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
13000
-
x * 33000, precursor form, x * 29000, mature form processed at prodomain alone, i.e. large subunit, x * 13000, small subunit, SDS-PAGE
15000
-
x * 15000, recombinant, active processed enzyme, SDS-PAGE, x * 35000, recombinant, inactive unprocessed enzyme, SDS-PAGE
19000
-
x * 19000, cleaved caspase-3, SDS-PAGE
29000
-
x * 33000, precursor form, x * 29000, mature form processed at prodomain alone, i.e. large subunit, x * 13000, small subunit, SDS-PAGE
33000
-
x * 33000, precursor form, x * 29000, mature form processed at prodomain alone, i.e. large subunit, x * 13000, small subunit, SDS-PAGE
35000
-
x * 15000, recombinant, active processed enzyme, SDS-PAGE, x * 35000, recombinant, inactive unprocessed enzyme, SDS-PAGE
56300
calculated from sequence
75000
-
gel filtration
additional information