3.4.22.56: caspase-3
This is an abbreviated version!
For detailed information about caspase-3, go to the full flat file.
Word Map on EC 3.4.22.56
-
3.4.22.56
-
bcl-2
-
caspase-9
-
necrosis
-
tunel
-
parp
-
anti-apoptotic
-
neuroprotective
-
pro-apoptotic
-
tnf
-
endothelial
-
annexin
-
leukemia
-
apoptosis-related
-
mapks
-
fas
-
ischemia
-
dismutase
-
deoxynucleotidyl
-
erk
-
neurotoxicity
-
artery
-
cyclin
-
cerebral
-
dutp
-
malondialdehyde
-
reperfusion
-
infarct
-
nick
-
cardiac
-
sirna
-
apoptosis-inducing
-
myocardial
-
gsh
-
cardiomyocytes
-
sham
-
c-jun
-
cisplatin
-
survivin
-
transferase-mediated
-
iodide
-
hippocampal
-
adp-ribose
-
hoechst
-
antiproliferative
-
caspase-dependent
-
polyadp-ribose
-
bid
-
ischemia-reperfusion
-
propidium
-
ladder
-
analysis
-
drug development
-
molecular biology
-
medicine
-
diagnostics
- 3.4.22.56
- bcl-2
- caspase-9
- necrosis
-
tunel
- parp
-
anti-apoptotic
-
neuroprotective
-
pro-apoptotic
- tnf
- endothelial
-
annexin
- leukemia
-
apoptosis-related
- mapks
- fas
- ischemia
- dismutase
-
deoxynucleotidyl
- erk
-
neurotoxicity
- artery
- cyclin
- cerebral
- dutp
- malondialdehyde
-
reperfusion
- infarct
- nick
- cardiac
- sirna
-
apoptosis-inducing
- myocardial
- gsh
- cardiomyocytes
-
sham
- c-jun
- cisplatin
- survivin
-
transferase-mediated
- iodide
- hippocampal
- adp-ribose
-
hoechst
-
antiproliferative
-
caspase-dependent
-
polyadp-ribose
- bid
-
ischemia-reperfusion
- propidium
-
ladder
- analysis
- drug development
- molecular biology
- medicine
- diagnostics
Reaction
strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-/- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position =
Synonyms
apopain, C14.003, Cas-3, CASP-3, CASP3, caspase 3, caspase-3, CgCaspase-3, CPP-32, CPP32, CPP32/apopain, cystein aspartic-specific protease-3, cysteine aspartic acid-specific protease, cysteine protease CPP32, DEVDase, IRP, Lyccasp3, Mncaspase-3c, More, SBTc-3, SCA-1, SREBP cleavage activity 1, Yama protein, Yama/CPP32, ZCASP3
ECTree
3.4.22.56 caspase-3Advanced search results
results (
results (Turnover Number
Turnover Number on EC 3.4.22.56 - caspase-3
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0217
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Ala-Pro-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.0183
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Ala-Val-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.017
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Asn-Pro-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.013
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Asn-Val-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.015
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Glu-Val-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.00917
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Gly-Pro-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.0083
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Gly-Val-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.023
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Leu-Pro-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.015
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Leu-Val-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.028
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Val-Pro-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.023
N-(5(6)-carboxyfluoresceinyl)-6-aminohexanoyl-Asp-Val-Val-Asp-6-aminohexanoyl-N6-[methyl red]-Lys-[N-(6-aminohexyl)-Gly]8-N2-(6-aminohexyl)-Gly-NH2
pH and temperature not specified in the publication
0.08
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant DELTA176-181, pH 4.75, 37°C
0.33
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
wild-type, pH 4.75, 37°C
1.37
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant D179A, pH 4.75, 37°C
1.54
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant DELTA176-181, pH 7.2, 37°C
3.5
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant D179A, pH 7.2, 37°C
6.01
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
wild-type, pH 7.2, 37°C
19.56
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant D179A, pH 7.2, 37°C
0.03 - 0.55
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
wild-type, pH 7.2, 37°C
0.06
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant DELTA176-181, pH 4.75, 37°C
0.16
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
wild-type, pH 4.75, 37°C
1.1
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant D179A, pH 4.75, 37°C
1.1
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant D179A, pH 7.2, 37°C
1.43
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant DELTA176-181, pH 7.2, 37°C
7.08
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
wild-type, pH 7.2, 37°C
19.04
benzoyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
mutant D179A, pH 7.2, 37°C
additional information
acetyl-L-Asp-L-Glu-L-Val-L-Asp-7-amido-4-methylcoumarin
wild-type, pH 7.2, 37°C
