Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.56: caspase-3

This is an abbreviated version!
For detailed information about caspase-3, go to the full flat file.

Word Map on EC 3.4.22.56

Reaction

strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-/- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position =

Synonyms

apopain, C14.003, Cas-3, CASP-3, CASP3, caspase 3, caspase-3, CgCaspase-3, CPP-32, CPP32, CPP32/apopain, cystein aspartic-specific protease-3, cysteine aspartic acid-specific protease, cysteine protease CPP32, DEVDase, IRP, Lyccasp3, Mncaspase-3c, More, SBTc-3, SCA-1, SREBP cleavage activity 1, Yama protein, Yama/CPP32, ZCASP3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.56 caspase-3

IC50 Value

IC50 Value on EC 3.4.22.56 - caspase-3

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0142
(3S)-3-([[(4-fluorophenyl)amino](oxo)acetyl]amino)-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00066
(3S)-3-([[2-(3-carboxypropyl)-1,3-dioxo-8-(2-phenylethyl)-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl]amino)-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.00681
(3S)-3-([[2-(3-carboxypropyl)-1,3-dioxo-8-(pyridin-3-yl)-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl]amino)-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.00524
(3S)-3-([[2-(3-carboxypropyl)-1,3-dioxo-8-[2-[(thiophen-2-ylacetyl)amino]ethyl]-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl]amino)-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.00505
(3S)-3-([[2-(3-carboxypropyl)-8-(2-[[(4-chlorophenyl)acetyl]amino]ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl]amino)-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.0172
(3S)-3-([[2-[2-[(1H-benzimidazol-6-ylcarbonyl)amino]ethyl]-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl]amino)-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.00754
(3S)-3-([[2-[2-[(cyclohexylcarbonyl)amino]ethyl]-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl]amino)-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.0134
(3S)-3-[[(2-[4-carboxy-2-[(phenylacetyl)amino]butyl]-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl)carbonyl]amino]-5-[(2,6-dichlorobenzoyl)oxy]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.0084
(3S)-5-(2,6-difluorophenoxy)-3-([[(2-methoxyphenyl)amino](oxo)acetyl]amino)-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.0252
(3S)-5-(2,6-difluorophenoxy)-3-([[(3-methylphenyl)amino](oxo)acetyl]amino)-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00967
(3S)-5-(2,6-difluorophenoxy)-3-([[(4-methylphenyl)amino](oxo)acetyl]amino)-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00347
(3S)-5-fluoro-3-([[(4-fluorophenyl)amino](oxo)acetyl]amino)-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00203
(3S)-5-[(2,6-dichlorobenzoyl)oxy]-3-[([1,3-dioxo-2-[2-(1H-tetrazol-5-yl)ethyl]-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl)amino]-4-oxopentanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.018
(R)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin
Homo sapiens
IC50: 0.018 mM
0.0055
(R)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 0.0055 mM
0.000044
(S)-(+)-5-[1-[2-(thiophenoxymethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 44 nM
0.000017
(S)-1-((1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000066
(S)-1-(11,11-difluoroundecyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.0005
(S)-1-(2-fluoroallyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.00184
(S)-1-(2-fluoroethyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.0000133
(S)-1-(3-chloro-2-hydroxypropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.00009
(S)-1-(3-chloropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.000025
(S)-1-(3-fluorobutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.00512
(S)-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.000078
(S)-1-(3-hydroxypropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.000041
(S)-1-(4-fluorobutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.00003
(S)-1-(4-hydroxybutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.0000042
(S)-1-(4-pyridinylmethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonal]isatin
Homo sapiens
IC50: 4.2 nM
0.00017
(S)-1-(carboxymethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 170 nM
0.0000052
(S)-1-(cyclohexylmethyl)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonal]isatin
Homo sapiens
IC50: 5.2 nM
0.0000046
(S)-1-allyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 4.6 nM
0.0000025
(S)-1-benzyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 2.5 nM
0.000029
(S)-1-butyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.000183
(S)-1-ethyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.0000024
(S)-1-methyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.00003
(S)-1-methyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 30 nM
0.0000053
(S)-1-propyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-isatin
Homo sapiens
-
37°C
0.0000031
(S)-1-[(tert-butyloxycarbonyl)methyl]-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 3.1 nM
0.1
(S)-1-[3-(3-fluoropropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
above, 37°C
0.0609
(S)-1-[3-(3-hydroxypropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.00943
(S)-1-[3-[3-(2-fluoroethoxy)propoxy]propyl]-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
Homo sapiens
-
37°C
0.0068
(S)-3,3-difluoro-1-(3-fluoropropyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]indolin-2-one
Homo sapiens
-
37°C
0.1
(S)-3,3-difluoro-1-propyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]indolin-2-one
Homo sapiens
-
above, 37°C
0.000043
(S)-3,5-bis-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.1
(S)-3-[3-[5-(1-(2-methoxymethylpyrrolidinyl)sulfonyl)-2,3-dioxoindolin-1-yl]propoxy]-propyl methanesulfonate
Homo sapiens
-
above, 37°C
0.000187
(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propanoic acid
Homo sapiens
-
37°C
0.00023
(S)-3-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]propyl methanesulfonate
Homo sapiens
-
37°C
0.000191
(S)-4-fluorobenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.000082
(S)-4-trifluoromethylbenzyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Homo sapiens
-
37°C
0.000056
(S)-4-[5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-2,3-dioxoindolin-1-yl]butyl 4-methyl-benzenesulfonate
Homo sapiens
-
37°C
0.00012
(S)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin
Homo sapiens
IC50: 120 nM
0.000359
(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,3,3-trifluoropropyl)isatin
Homo sapiens
-
37°C
0.000083
(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(3,4,4-trifluorobut-3-enyl)isatin
Homo sapiens
-
37°C
0.000213
(S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-(4,4,4-trifluorobutyl)isatin
Homo sapiens
-
37°C
0.00017
(S)-5-[1-[(2-methoxycarbonyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 170 nM
0.00007
(S)-5-[1-[(2-tert-butoxycarbonyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 70 nM
0.000031
(S)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 31 nM
0.000044
(S)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 44 nM
0.00014
(S)-5-[1-[2-(phenylaminocarbonyl)pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 140 nM
0.00041
(S)-5-[1-[[2-(dimethylamino)carbonyl]pyrrolidinyl]sulfonyl]isatin
Homo sapiens
IC50: 410 nM
0.04674
1,2-benzisothiazol-3-one
Homo sapiens
-
at pH 7.5 and 22°C
0.000245
1-(3-oxo-1,2-benzothiazol-2(3H)-yl)-4-(thiophen-2-yl)butane-1,4-dione
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.001
1-methyl-5-nitro-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000136
1-[[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-1,2,3-triazol-5-yl]methyl]-5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.0000167
1-[[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]methyl]-5-[[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000023
1-[[1-(biphenyl-4-yl)-1H-1,2,3-triazol-4-yl]methyl]-5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000136
1-[[1-(biphenyl-4-yl)-1H-1,2,3-triazol-5-yl]methyl]-5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.0002217
2-(1,3-dihydro-2-benzofuran-5-ylacetyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000000203
2-(2,6-dihydroxyphenyl)-4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.01855
2-(2-phenylethyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.000729
2-(3-oxo-1,2-benzothiazol-2(3H)-yl)-N-[4-(1H-pyrrol-1-yl)phenyl]acetamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000501
2-(3-oxo-1,2-benzothiazol-2(3H)-yl)-N-[4-(pyridin-2-yl)phenyl]acetamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001084
2-(3-phenylpropanoyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.01364
2-(4-fluorobenzyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.01209
2-(4-methoxybenzyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.0004657
2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.0001816
2-(4-phenylbutanoyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0003061
2-(5-phenylpentanoyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5,temperature not specified in the publication
0.0001406
2-(biphenyl-4-ylacetyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00000008
2-(chloroacetyl)-4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.0002646
2-(naphthalen-2-ylacetyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0002921
2-(phenylacetyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.02272
2-(prop-2-en-1-yl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.0322
2-(thiophen-2-ylacetyl)-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000000622
2-amino-4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.0108
2-benzyl-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.09124
2-ethyl-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.04239
2-methyl-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.0005328
2-phenyl-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5 and 22°C
0.00000019
2-[(2,6-dihydroxyphenyl)amino]-4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.001926
2-[(2-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001857
2-[(2-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000000425
2-[(2-hydroxyphenyl)amino]-4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.0002186
2-[(2-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001999
2-[(2-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0006543
2-[(3,4-dichlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00000263
2-[(3,5-diamino-4-hydroxyphenyl)amino]-4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.0002719
2-[(3-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.008985
2-[(3-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000548
2-[(3-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0003392
2-[(3-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0002151
2-[(4-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.001196
2-[(4-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0003263
2-[(4-hydroxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00000033
2-[(4-hydroxyphenyl)amino]-4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.001344
2-[(4-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0002143
2-[(4-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0000473
2-[3-(2-chlorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001297
2-[3-(2-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001357
2-[3-(2-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0000877
2-[3-(3-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0000349
2-[3-(3-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000095
2-[3-(3-methylphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0000569
2-[3-(4-chlorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001116
2-[3-(4-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0000497
2-[3-(4-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000119
2-[3-(4-methylphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0003897
2-[4-(4-methoxyphenyl)butanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0002659
2-[4-(4-methylphenyl)butanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001266
2-[4-(thiophen-2-yl)butanoyl]-1,2-benzothiazol-3(2H)-one
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.032
3-hydroxyl-anthranilamide
Rattus norvegicus
-
pH 7.5, 35°C
0.000085
3-oxo-N-(1-phenylethyl)-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000031
3-oxo-N-(2-phenylethyl)-1,2-benzothiazole-2(3H)-carboxamide
0.00004904
3-oxo-N-(3-phenylpropyl)-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000076
3-oxo-N-phenyl-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.00004939
3-oxo-N-[2-(pyridin-2-yl)ethyl]-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00003105
3-oxo-N-[2-(thiophen-2-yl)ethyl]-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00009792
3-oxo-N-[4-(piperidin-1-yl)phenyl]-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0000221
3-oxo-N-[4-(pyridin-2-yl)phenyl]-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00082
3-[[(2-methyl-1H-indol-1-yl)acetyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.000988
3-[[(5-bromo-1H-indol-1-yl)acetyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.0012
3-[[(5-bromo-1H-indol-1-yl)acetyl]amino]-5-(2,6-difluorophenoxy)-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00058
3-[[(5-bromo-1H-indol-1-yl)acetyl]amino]-5-fluoro-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00011
3-[[(5-chloro-1H-indol-1-yl)acetyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.0208
3-[[(5-chloro-1H-indol-1-yl)acetyl]amino]-5-(2,6-difluorophenoxy)-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00035
3-[[(5-chloro-1H-indol-1-yl)acetyl]amino]-5-fluoro-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00084
3-[[(5-fluoro-1H-indol-1-yl)acetyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00111
3-[[(5-methoxy-1H-indol-1-yl)acetyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.000000228
4-methyl-2-(1-methylethyl)-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.000000324
4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-2-(1,3-thiazol-2-yl)-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.000000446
4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-2-(2,4,6-trihydroxyphenyl)-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.000000124
4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-2-(phenylamino)-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.000000243
4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-2-[(2,4,6-trihydroxyphenyl)amino]-1H-cyclopenta[c]quinoline-1,3(2H)-dione
Homo sapiens
-
-
0.00000161
4-[4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1,3-dioxo-2,3-dihydro-1H-cyclopenta[c]quinolin-2-yl]benzoic acid
Homo sapiens
-
-
0.00913
4-[5-([(3S)-1-[(2,6-dichlorobenzoyl)oxy]-2,5-dioxohexan-3-yl]carbamoyl)-1,3-dioxo-8-(thiophen-2-yl)-5,8-dihydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-2(3H)-yl]butanoic acid
Homo sapiens
-
pH 7.5, 25°C
0.0025
5-(2,6-difluorophenoxy)-3-[[(2-methyl-1H-indol-1-yl)acetyl]amino]-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.0257
5-(2,6-difluorophenoxy)-3-[[(5-fluoro-1H-indol-1-yl)acetyl]amino]-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.0471
5-(2,6-difluorophenoxy)-3-[[(5-methoxy-1H-indol-1-yl)acetyl]amino]-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.0000005
5-([(2R)-2-[(2,4-difluorophenoxy)methyl]pyrrolidin-1-yl]sulfonyl)-1-[[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00123
5-fluoro-3-[[(2-methyl-1H-indol-1-yl)acetyl]amino]-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00112
5-fluoro-3-[[(5-fluoro-1H-indol-1-yl)acetyl]amino]-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00129
5-fluoro-3-[[(5-methoxy-1H-indol-1-yl)acetyl]amino]-4-oxopentanoic acid
Homo sapiens
-
at pH 7.4 and 30°C
0.00017
5-[1-(azetidinyl)sulfonyl]isatin
Homo sapiens
IC50: 170 nM
0.0019
5-[1-(hexamethyleneimino)sulfonyl]isatin
Homo sapiens
IC50: 0.0019 mM
0.0022
5-[1-(piperidinyl)sulfonyl]isatin
Homo sapiens
IC50: 0.0022 mM
0.0028
5-[1-(pyrrolidinyl)sulfonyl]isatin
Homo sapiens
IC50: 0.0028 mM
0.000018
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-([1-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000267
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-([1-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-5-yl]methyl)-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[(1-phenoxy-1H-1,2,3-triazol-4-yl)methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000009
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[(1-phenoxy-1H-1,2,3-triazol-5-yl)methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000021
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000103
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[(1-phenyl-1H-1,2,3-triazol-5-yl)methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000243
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[2-(1-phenyl-1H-1,2,3-triazol-4-yl)ethyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000207
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[2-(1-phenyl-1H-1,2,3-triazol-5-yl)ethyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000044
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00007
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[[1-(4-methoxyphenyl)-1H-1,2,3-triazol-5-yl]methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000021
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[[1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl]methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000213
5-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-[[1-(4-nitrophenyl)-1H-1,2,3-triazol-5-yl]methyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
5-[[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.000044
5-[[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
6-[[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione
Homo sapiens
-
37°C
0.036
8-hydroxyl-2,4-dioxoquinazoline
Rattus norvegicus
-
pH 7.5, 35°C
0.0000068
Ac-CV3-KE
Homo sapiens
-
at pH 7.4 and 22°C
0.0000012
Ac-DEVD-CHO
Homo sapiens
-
0.000012
Ac-DMQD-CHO
Homo sapiens
-
0.01
Ac-DW3-KE
Homo sapiens
-
at pH 7.4 and 22°C
-
0.000012
Ac-F-D-beta-hLeu-hLeu-D-KE
Homo sapiens
-
at pH 7.4 and 22°C
0.0012
Ac-IEPD-CHO
Homo sapiens
-
0.0019
Ac-WEHD-CHO
Homo sapiens
-
0.01
Ac-YVAD-CHO
Homo sapiens
-
0.000001
Asp-Glu-Val-Asp-aldehyde
Homo sapiens
-
IC50 for membrane enzyme: 1 nM
0.0000047
Asp-Phe-Leu-Asp-aldehyde
Homo sapiens
-
IC50 for membrane enzyme: 4.7 nM
0.000074
baculovirus p35
Homo sapiens
-
IC50 for membrane enzyme: 0.074 nM
-
0.000012
carbobenzyloxy-DEVD-fluoromethyl ketone
Homo sapiens
-
-
0.0136
CS4566
Homo sapiens
-
-
0.000027
FAM-Ahx2-CV3-AOMK
Homo sapiens
-
at pH 7.4 and 22°C
0.000018
FAM-DEVD-AOMK
Homo sapiens
-
at pH 7.4 and 22°C
0.000035
IDN6556
Homo sapiens
-
at pH 7.4 and 30°C
0.00003 - 0.00012
M826
0.0102
myricetin
Rattus norvegicus
-
pH 7.4, 37°C
0.008093
N-(2-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000206
N-(2-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.01627
N-(2-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000088
N-(2-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.004167
N-(2-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.009823
N-(2-nitrophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.009628
N-(3-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000241
N-(3-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000438
N-(3-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000074
N-(3-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.001167
N-(3-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.0004307
N-(4-benzoylphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.003071
N-(4-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000115
N-(4-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.000593
N-(4-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.1
N-(4-iodophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
IC50 above 0.1 mM, at pH 7.5 and 22°C
0.00004
N-(4-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.01071
N-(4-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.04674
N-(5-methylpyridin-2-yl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00008055
N-(furan-2-ylmethyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.000023
N-acetyl-3-(pyridin-3-yl)-L-alanyl-N-[(3S)-1-[[(2S)-1-([(2S)-1-carboxy-4-[(2,6-dimethylbenzoyl)oxy]-3-oxobutan-2-yl]amino)-5-methyl-1-oxohexan-2-yl]amino]-5-methyl-1-oxohexan-3-yl]-L-alpha-asparagine
Homo sapiens
-
at pH 7.4 and 22°C
0.0000002 - 0.0757
N-acetyl-DEVD-CHO
0.00004153 - 0.000086
N-benzyl-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
0.04
N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
Homo sapiens
pH 7.4, 37°C
0.04474
N-[(2-fluorophenyl)methyl]-N-methyl-2,3-dioxo-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide
Homo sapiens
37°C, pH 7.4
0.06096
N-[(2-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide
Homo sapiens
37°C, pH 7.4
0.05149
N-[(3-fluorophenyl)methyl]-N-methyl-2,3-dioxo-1-(prop-2-yn-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide
Homo sapiens
37°C, pH 7.4
0.02508
N-[(3-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide
Homo sapiens
37°C, pH 7.6
0.02926
N-[(4-fluorophenyl)methyl]-N-methyl-2,3-dioxo-2,3-dihydro-1H-indole-5-sulfonamide
Homo sapiens
37°C, pH 7.4
0.01356
N-[2-(4-methylpiperazin-1-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0002697
N-[2-(morpholin-4-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0001808
N-[3-(4-methylpiperazin-1-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.0000555
N-[3-(morpholin-4-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00006201
N-[4-(4-methylpiperazin-1-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00005685
N-[4-(morpholin-4-yl)benzyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00000115 - 0.0001063
N-[4-(morpholin-4-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
0.0007834
N-[4-(morpholin-4-ylsulfonyl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.02205
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5 and 22°C
0.0000606
N-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
Homo sapiens
-
at pH 7.5, temperature not specified in the publication
0.00001
Rho-DEVD-AOMK
Homo sapiens
-
at pH 7.4 and 22°C
0.000034
Val-Glu-Ile-Asp-aldehyde
Homo sapiens
-
IC50 for membrane enzyme: 34 nM
0.000000008
[4-methyl-8-[(2-nitropyrrolidin-1-yl)sulfonyl]-1,3-dioxo-2,3-dihydro-1H-cyclopenta[c]quinolin-2-yl](oxo)acetyl chloride
Homo sapiens
-
-