3.4.22.56: caspase-3
This is an abbreviated version!
For detailed information about caspase-3, go to the full flat file.
Word Map on EC 3.4.22.56
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3.4.22.56
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bcl-2
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caspase-9
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necrosis
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tunel
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parp
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anti-apoptotic
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neuroprotective
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pro-apoptotic
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tnf
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endothelial
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annexin
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leukemia
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apoptosis-related
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mapks
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fas
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ischemia
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dismutase
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deoxynucleotidyl
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erk
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neurotoxicity
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artery
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cyclin
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cerebral
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dutp
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malondialdehyde
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reperfusion
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infarct
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nick
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cardiac
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sirna
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apoptosis-inducing
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myocardial
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gsh
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cardiomyocytes
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sham
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c-jun
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cisplatin
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survivin
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transferase-mediated
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iodide
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hippocampal
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adp-ribose
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hoechst
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antiproliferative
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caspase-dependent
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polyadp-ribose
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bid
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ischemia-reperfusion
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propidium
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ladder
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analysis
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drug development
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molecular biology
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medicine
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diagnostics
- 3.4.22.56
- bcl-2
- caspase-9
- necrosis
-
tunel
- parp
-
anti-apoptotic
-
neuroprotective
-
pro-apoptotic
- tnf
- endothelial
-
annexin
- leukemia
-
apoptosis-related
- mapks
- fas
- ischemia
- dismutase
-
deoxynucleotidyl
- erk
-
neurotoxicity
- artery
- cyclin
- cerebral
- dutp
- malondialdehyde
-
reperfusion
- infarct
- nick
- cardiac
- sirna
-
apoptosis-inducing
- myocardial
- gsh
- cardiomyocytes
-
sham
- c-jun
- cisplatin
- survivin
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transferase-mediated
- iodide
- hippocampal
- adp-ribose
-
hoechst
-
antiproliferative
-
caspase-dependent
-
polyadp-ribose
- bid
-
ischemia-reperfusion
- propidium
-
ladder
- analysis
- drug development
- molecular biology
- medicine
- diagnostics
Reaction
strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-/- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position =
Synonyms
apopain, C14.003, Cas-3, CASP-3, CASP3, caspase 3, caspase-3, CgCaspase-3, CPP-32, CPP32, CPP32/apopain, cystein aspartic-specific protease-3, cysteine aspartic acid-specific protease, cysteine protease CPP32, DEVDase, IRP, Lyccasp3, Mncaspase-3c, More, SBTc-3, SCA-1, SREBP cleavage activity 1, Yama protein, Yama/CPP32, ZCASP3
ECTree
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Purification
Purification on EC 3.4.22.56 - caspase-3
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recombinant enzyme from Escherichia coli by nickel affinity chromatography, ion exchange chromatography, and gel filtration
recombinant His6-tagged caspase-3 from Escherichia coli by nickel affinity chromatography
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upon purification and activation, caspase-3 subunits A and B are processed to yield the sequences S29GIS...IETD175 and S176GVD
YFYH277-(H)7, the purified enzyme shows 90% of maximum activity
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