3.4.22.56: caspase-3

This is an abbreviated version!
For detailed information about caspase-3, go to the full flat file.

Word Map on EC 3.4.22.56

3.4.22.56

bcl-2

caspase-9

necrosis

tunel

parp

anti-apoptotic

neuroprotective

pro-apoptotic

tnf

endothelial

annexin

leukemia

apoptosis-related

mapks

fas

ischemia

dismutase

deoxynucleotidyl

erk

neurotoxicity

artery

cyclin

cerebral

dutp

malondialdehyde

reperfusion

infarct

nick

cardiac

sirna

apoptosis-inducing

myocardial

gsh

cardiomyocytes

sham

c-jun

cisplatin

survivin

transferase-mediated

iodide

hippocampal

adp-ribose

hoechst

antiproliferative

caspase-dependent

polyadp-ribose

bid

ischemia-reperfusion

propidium

ladder

analysis

drug development

molecular biology

medicine

diagnostics

Reaction

strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-/- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position =

Synonyms

apopain, C14.003, Cas-3, CASP-3, CASP3, caspase 3, caspase-3, CgCaspase-3, CPP-32, CPP32, CPP32/apopain, cystein aspartic-specific protease-3, cysteine aspartic acid-specific protease, cysteine protease CPP32, DEVDase, IRP, Lyccasp3, Mncaspase-3c, More, SBTc-3, SCA-1, SREBP cleavage activity 1, Yama protein, Yama/CPP32, ZCASP3

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.56 caspase-3

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
66	Activating Compound
31	AA Sequence
22	Application
1	CAS Registry Number
26	Cloned(Commentary)
8	Crystallization (Commentary)
28513	Disease/ Diagnostics
15	Expression
20	General Information
237	IC50 Value
514	Inhibitors
11	kcat/KM [mM/s]
79	Ki Value [mM]
53	KM Value [mM]
19	Localization
9	Molecular Weight [Da]
104	Natural Substrates/ Products (Substrates)
423	Organism
208	PDB ID
26	pH Optimum
1	pI Value
26	Posttranslational Modification
15	Protein Variants
13	Purification (Commentary)
2	Reaction
1	Reaction Type
212	Reference
305	Source Tissue
9	Specific Activity [micromol/min/mg]
266	Substrates and Products (Substrate)
10	Subunits
48	Synonyms
28	Temperature Optimum [°C]
35	Turnover Number [1/s]

KI Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

KI Value on EC 3.4.22.56 - caspase-3

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

back to the top

Go to Ki Value Search

0.000165

(3S)-3-[[(2R)-2-[3-[(naphthalen-2-ylcarbonyl)amino]-2-oxopyridin-1(2H)-yl]-2-phenylacetyl]amino]-4-oxo-5-phenoxypentanoic acid

-

Ki-value is calculated from the initial rates

0.0021

(4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxymethyl)-13-(cyclobutylcarbonyl)-10-(1-methylethyl)-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

-

-

0.012

(R)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin

pH 7.5, 30°C

0.0000012

(S)-1-benzyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin

pH 7.5, 30°C

0.000019

(S)-1-[(tert-butyloxycarbonyl)methyl]-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin

pH 7.5, 30°C

0.00016

(S)-3-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-pyridin-2-ylmethyl]sulfamoyl]benzoic acid

-

pH 7.4

0.0017

(S)-3-[[6-(benzenesulfonylamino-methyl)pyridine-3-carbonyl]amino]-4-oxo-butyric acid

-

pH 7.4

0.00047

(S)-3-[[6-[(3-acetylsulfamoyl-benzenesulfonylamino)-methyl]pyridine-3-carbonyl]amino]-4-oxo-butyric acid

-

pH 7.4

0.0017

(S)-3-[[6-[(3-methanesulfonyl-benzenesulfonylamino)-methyl]pyridine-3-carbonyl]amino]-4-oxo-butyric acid

-

pH 7.4

0.0013

(S)-3-[[6-[(3-methanesulfonylamino-benzenesulfonylamino)methyl]pyridine-3-carbonyl]amino]-4-oxo-butyric acid

-

pH 7.4

0.0014

(S)-3-[[6-[(3-methanesulfonylaminocarbonyl-benzenesulfonylamino)methyl]-pyridine-3-carbonyl]amino]-4-oxobutyric acid

-

pH 7.4

0.0023

(S)-3-[[6-[(4-hydroxy-benzenesulfonylamino)methyl]-pyridine-3-carbonyl]amino]-4-oxo-butyric acid

-

pH 7.4

0.0019

(S)-3-[[6-[(4-methanesulfonylamino-benzenesulfonylamino)methyl]pyridien-3-carbonyl]amino]-4-oxo-butyric acid

-

pH 7.4

0.00044

(S)-4-oxo-3-[[6-[[3-(1H-tetrazol-5-yl)benzenesulfonylamino]methyl]pyridine-3-carbonyl]amino]butyric acid

-

pH 7.4

0.0004

(S)-4-oxo-3-[[6-[[3-(5-oxo-4,5-dihydro[1,2,4]oxadiazol-3-yl)benzenesulfonylamino]methyl]pyridien-3-carbonyl]amino]butyric acid

-

pH 7.4

0.00021

(S)-4-[[4-(hydroxy-3-methyl-benzenesulfonylamino)methyl]thiophene]-2-carboxylic acid [3-(2-chloro-benzylsulfanyl)-1-ethyl-2-oxo-propyl]amide

-

pH 7.4

0.00006

(S)-5-[1-(2-methoxymethyl)pyrrolidinylsulfonyl]isatin

pH 7.5, 30°C

0.000015

(S)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin

pH 7.5, 30°C

0.00016

(S)-5-[[3-(1-carboxymethyl-2-oxo-ethylcarbamoyl)isooxazol-5-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00006

(S)-5-[[3-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]isoxazol-5-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.0025

(S)-5-[[4-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00029

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-4-methyl-thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.0125

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-furan-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00048

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-pyrazin-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00007

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-thiazol-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00012

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.004

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)-thiophen-3-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00005

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)pyridin-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00002

(S)-5-[[5-(1-carboxymethyl-2-oxo-ethylcarbamoyl)pyrimidin-2-ylmethyl]sulfamoyl]-2-hydroxybenzoic acid

-

pH 7.4

0.00019

(S)-5-[[5-(1-carboxymethyl-3-methylsulfanyl-2-oxo-propylcarbamoyl)pyridin-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00002

(S)-5-[[5-[1-carboxymethyl-2-oxo-3-(pyridin-3-ylmethylsulfanyl)propylcarbamoyl]thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00003

(S)-5-[[5-[1-carboxymethyl-2-oxo-3-(pyridin-4-ylmethylsulfanyl)propylcarbamoyl]thiophen-2-ylmethyl]-sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00004

(S)-5-[[5-[1-carboxymethyl-3(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]-4-methyl-thiophen-2-ylmethyl]-sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.004

(S)-5-[[5-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]furan-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00009

(S)-5-[[5-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]pyrazin-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00003

(S)-5-[[5-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]pyridin-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00002

(S)-5-[[5-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]pyrimidin-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00003

(S)-5-[[5-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]thiazol-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00002

(S)-5-[[5-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00027

(S)-5-[[5-[1-carboxymethyl-3-(2-chloro-benzylsulfanyl)-2-oxo-propylcarbamoyl]thiophen-3-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00024

(S)-5-[[5-[1-carboxymethyl-5-(2-chloro-phenyl)-2-oxopentylcarbamoyl]thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.000011

1-methyl-5-[[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl]-1H-indole-2,3-dione

-

Ki-value is calculated from the initial rates

0.000077

3,3-dimethyl-8-[[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl]-3,4-dihydropyrimido[1,2-a]indol-10(2H)-one

-

Ki-value is calculated from the initial rates

0.0000161

5-([(2S)-2-[(pyridin-3-yloxy)methyl]pyrrolidin-1-yl]sulfonyl)-1H-indole-2,3-dione

-

Ki-value is calculated from the initial rates

0.0014

5-[1-(pyrrolidinyl)sulfonyl]isatin

pH 7.5, 30°C

0.0000025

5-[[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl]-1-phenyl-1H-indole-2,3-dione

-

Ki-value is calculated from the initial rates

0.00029

5-[[5-[1-carboxymethyl-2-(7-methyl-benzoxazol-2-yl)-2-oxo-ethylcarbamoyl]thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.00038

5-[[5-[1-carboxymethyl-2-[5-(2,6-dichloro-phenyl)-oxazol-2-yl]-2-oxo-ethylcarbamoyl]thiophen-2-ylmethyl]sulfamoyl]-2-hydroxy-benzoic acid

-

pH 7.4

0.000478

8-[[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl]-3,3-dimethyl-3,4-dihydropyrimido[1,2-a]indol-10(2H)-one

-

Ki-value is calculated from the initial rates

0.000042

acetyl-AEVD-aldehyde

-

pH 7.5, 25°C

0.045

acetyl-Ala-Pro-Nle-Asp-aldehyde

-

pH 7.5

0.0000013 - 0.0058

Acetyl-Asp-Glu-Val-Asp-aldehyde

show

0.0000124

acetyl-Asp-Met-Gln-Asp-aldehyde

pH 7.5, 22°C

0.00000023 - 0.0008

acetyl-DEVD-aldehyde

show

0.000195

acetyl-IETD-aldehyde

-

pH 7.5, 25°C

0.0000065

acetyl-Val-Asp-Val-Ala-Asp-aldehyde

pH 7.5, 22°C

0.00196

acetyl-WEHD-aldehyde

-

pH 7.5, 25°C

0.012

acetyl-YVAD-aldehyde

-

pH 7.5

0.022

benzyloxycarbonyl-Pro-Nle-Asp-aldehyde

-

pH 7.5

0.000108

c-IAP-1

-

37°C

-

0.000035

c-IAP-2

-

37°C

-

0.0016

cowpox serpin CrmA

-

pH 7.5, 25°C

-

0.022

m-(Ac-L-Asp-L-Val-NH)-N-nitroso-N-phenylglycine

-

pH 7.5, 37°C

0.0015

N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-phenylpropyl]-L-valinamide

-

-

0.0035

N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxo-4-phenylbutyl]-L-valinamide

-

-

0.0011

N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxoheptyl]-L-valinamide

-

-

0.0013

N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-2-oxooctyl]-L-valinamide

-

-

0.0002

N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-4-(2,5-dimethylphenyl)-2-oxobutyl]-L-valinamide

-

-

0.0007

N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-4-(3-methylphenyl)-2-oxobutyl]-L-valinamide

-

-

0.002

N-acetyl-L-alpha-aspartyl-L-valyl-N-[(1S)-2-carboxy-1-[[(4-methylphenyl)(nitroso)amino]methyl]ethyl]-L-alaninamide

-

pH 7.5, 30°C

0.0000036

N-benxylozycarbonyl-tLeu-Asp

-

pH 7.4, 25°C

0.0000182

N-benxylozycarbonyl-tLeu-Val-Asp

-

pH 7.4, 25°C

0.000109

N-benxylozycarbonyl-Val-tLeu-Asp

-

pH 7.4, 25°C

0.000036

survivin

-

pH 7.5, 37°C

-

additional information

additional information

show

-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)