3.4.21.79: granzyme B
This is an abbreviated version!
For detailed information about granzyme B, go to the full flat file.
Word Map on EC 3.4.21.79
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3.4.21.79
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perforin
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t-cells
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cd8
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cytolytic
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immunotherapy
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vaccine
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lymphoma
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rejection
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tnf
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dendritic
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cell-mediated
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ifn-gamma
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allograft
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tregs
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tia-1
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fasl
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foxp3
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autologous
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interferon-gamma
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caspases
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degranulation
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allogeneic
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epstein-barr
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antigen-specific
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virus-specific
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immunophenotype
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ctla-4
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anti-cd3
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tumor-infiltrating
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nk-cell
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extranodal
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elispot
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synthesis
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eomes
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graft-versus-leukemia
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cd45ro
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alcls
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biotechnology
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death-1
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analysis
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intragraft
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lag-3
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hiv-specific
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medicine
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diagnostics
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degradation
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alloreactive
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lymphocyte-mediated
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lymphokine-activated
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crma
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b-mediated
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pharmacology
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ag-specific
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banff
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hepatosplenic
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anti-pd-1
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interleukin-15
- 3.4.21.79
- perforin
- t-cells
- cd8
-
cytolytic
-
immunotherapy
- vaccine
- lymphoma
-
rejection
- tnf
- dendritic
-
cell-mediated
- ifn-gamma
-
allograft
-
tregs
- tia-1
- fasl
- foxp3
-
autologous
- interferon-gamma
-
caspases
-
degranulation
-
allogeneic
-
epstein-barr
-
antigen-specific
-
virus-specific
-
immunophenotype
-
ctla-4
-
anti-cd3
-
tumor-infiltrating
-
nk-cell
-
extranodal
-
elispot
- synthesis
-
eomes
-
graft-versus-leukemia
-
cd45ro
-
alcls
- biotechnology
-
death-1
- analysis
-
intragraft
- lag-3
-
hiv-specific
- medicine
- diagnostics
- degradation
-
alloreactive
-
lymphocyte-mediated
-
lymphokine-activated
- crma
-
b-mediated
- pharmacology
-
ag-specific
-
banff
-
hepatosplenic
-
anti-pd-1
- interleukin-15
Reaction
preferential cleavage: -Asp-/- >> -Asn-/- > -Met-/-, -Ser-/- =
Synonyms
Asp-ase, C11, CCP1, CCPII, CTLA1, CTSGL1, Cytotoxic cell proteinase-1, cytotoxic lymphocyte-associated protease, cytotoxic lymphocyte-specific protein, cytotoxic serine protease granzyme B, cytotoxic T-lymphocyte-associated gene transcript-1, gB, Gra-b, granzyme B, Granzyme G, Granzyme H, GrB, GrzmB, GzB, Gzm, Gzm B, GzmB, GzmB-like enzyme, GzmH, HLp, Human lymphocyte protein, Lymphocyte protease, natural killer cell protease 1, pro-apoptotic serine protease, proGrB, Proteinase, CCP1, rat grB[N66Q], SECT, T-cell serine protease 1-3E
ECTree
3.4.21.79 granzyme BAdvanced search results
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results (Activating Compound
Activating Compound on EC 3.4.21.79 - granzyme B
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
A23187
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induces granzyme B expression in mast cell lines HMC-1 and LAD2 and cord blood-derived mast cells
compound 48/80
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induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells
Substance P
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induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells
additional information
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CMV/EBV/influenza peptide pool peptides do not induce GzB release in CD8+ cells from healthy donors within 24 h. Purified CD8+ cells after CMV/EBV/influenza peptide pool peptide stimulation show induction of GzB after 72 h in vitro. HIV peptides induce GzB secretion in HIV-infected individuals directly ex vivo
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additional information
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GzB is not induced in purified CD8+ cells by CEF peptides ex vivo. Low frequencies of GzB producing CD8+ cells after mitogen stimulation. IFN-gamma positive, GzB negative CD8+ memory cells convert into GzB producing cells within 2 days after antigen stimulation. Induction of GzB producing CD8+ cells after Vaccinia virus booster immunization. HIV peptides induce GzB production in HIV-infected individuals directly ex vivo
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additional information
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mature skin-derived mast cells only produce granzyme B upon IgE-dependent stimulation by FcepsilonRI
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additional information
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natural killer cells stimulated in vitro with interleukin-2 express progressively greater amounts of perforin and granzyme B
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additional information
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no GzB activity in CTL or NK92 effector cells, but activity rapidly becomes detectable throughout the target cytoplasm after effector-target engagement. Lack of GzB activity in Jurkat cells following intrinsic and extrinsic apoptotic stimuli
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additional information
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activation of CD4+ T cells with anti-CD3 and anti-CD28 or anti-CD46 induces granzyme B expression in all cells. Granzyme B expression in anti-CD3/anti-CD46 activated CD4+ T cells is much higher than granzyme B expression induced by usual activation (anti-CD3/anti-CD28)
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additional information
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granzyme B level is elevated in the early stage of Rasmussen syndrome around the onset of epilepsy and remains slightly elevated even in the progressed stage, and declines within a few months to more or less constant levels
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additional information
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in the presence of perforin, modest cleavage of the encapsulated PEG-P at large unilamellar vesicles/perforin molar ratio of 1000 at acidic and neutral pH. Granzyme B requires a translocation agent to enter the target cell. Granzyme B readily accesses PEG-P only when a membrane disrupting agent, e.g. TX-100, streptolysin O or perforin, is present
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additional information
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in vitro stimulation increases the mRNA levels of GZMB in both naive and memory cells. Activation-induced GZMB expression increases significantly faster and higher in memory cells than in naive cells for the first 24-32 h. At 72 h after stimulation, naive cells express higher levels of GZMB than do memory cells
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additional information
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plasma level of granzyme B increases significantly by day 14, with a peak at day 7 after onset of acute myocardial infarction. Significant positive correlation between the plasma granzyme B level on day 14 and the increase in left ventricular end-diastolic volume index over 6 months after acute myocardial infarction
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additional information
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ristocetin does not increase granzyme B cleavage in the presence or absence of salt
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additional information
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granzyme B expression in Treg cells is activated by syngeneic tumor cell line
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additional information
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induction of granzyme B by a DNase1 hypersensitive site 3.9 kb upstream of the transcription start site of granzyme B
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additional information
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secreted after Fcepsilon-receptor-mediated activation in cytoplasmic granules of bone marrow-derived mast cells
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additional information
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sepsis induces platelet granzyme B expression. In septic mice, granzyme B expression significantly increases by 24 h in megakaryocytes and platelets
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