3.4.21.79: granzyme B

This is an abbreviated version!
For detailed information about granzyme B, go to the full flat file.

Word Map on EC 3.4.21.79

3.4.21.79

perforin

t-cells

cd8

cytolytic

immunotherapy

vaccine

lymphoma

rejection

tnf

dendritic

cell-mediated

ifn-gamma

allograft

tregs

tia-1

fasl

foxp3

autologous

interferon-gamma

caspases

degranulation

allogeneic

epstein-barr

antigen-specific

virus-specific

immunophenotype

ctla-4

anti-cd3

tumor-infiltrating

nk-cell

extranodal

elispot

synthesis

eomes

graft-versus-leukemia

cd45ro

alcls

biotechnology

death-1

analysis

intragraft

lag-3

hiv-specific

medicine

diagnostics

degradation

alloreactive

lymphocyte-mediated

lymphokine-activated

crma

b-mediated

pharmacology

ag-specific

banff

hepatosplenic

anti-pd-1

interleukin-15

Reaction

preferential cleavage: -Asp-/- >> -Asn-/- > -Met-/-, -Ser-/- =

Synonyms

Asp-ase, C11, CCP1, CCPII, CTLA1, CTSGL1, Cytotoxic cell proteinase-1, cytotoxic lymphocyte-associated protease, cytotoxic lymphocyte-specific protein, cytotoxic serine protease granzyme B, cytotoxic T-lymphocyte-associated gene transcript-1, gB, Gra-b, granzyme B, Granzyme G, Granzyme H, GrB, GrzmB, GzB, Gzm, Gzm B, GzmB, GzmB-like enzyme, GzmH, HLp, Human lymphocyte protein, Lymphocyte protease, natural killer cell protease 1, pro-apoptotic serine protease, proGrB, Proteinase, CCP1, rat grB[N66Q], SECT, T-cell serine protease 1-3E

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.79 granzyme B

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Results	in table
24	Activating Compound
6	AA Sequence
55	Application
1	CAS Registry Number
31	Cloned(Commentary)
3	Crystallization (Commentary)
3468	Disease/ Diagnostics
15	Expression
54	General Information
7	IC50 Value
95	Inhibitors
3	kcat/KM [mM/s]
8	Ki Value [mM]
38	KM Value [mM]
24	Localization
7	Metals/Ions
16	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
142	Organism
3	PDB ID
13	pH Optimum
1	pH Range
6	Posttranslational Modification
56	Protein Variants
32	Purification (Commentary)
1	Reaction
1	Reaction Type
140	Reference
165	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
360	Substrates and Products (Substrate)
9	Subunits
117	Synonyms
7	Temperature Optimum [°C]
24	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.79 - granzyme B

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0.0058 - 0.0387

2-aminobenzoyl-IEPDSSMEK-dnp

show

0.0058

2-aminobenzoyl-IEPDSSMESK-dnp

-

pH 7.4, 37°C

0.0701

2-aminobenzoyl-VVADSSMASK-dnp

-

pH 7.4, 37°C

0.013

2-aminobenzoyl-VVADSSMESK-dnp

-

pH 7.4, 37°C

0.0643

2-aminobenzoyl-VVAESSMESK-dnp

-

pH 7.4, 37°C

0.0057 - 0.0058

Abz-IEPDSSMESK-DNP

show

0.1512 - 0.447

Ac-IEPD-p-nitroanilide

show

0.15 - 1.3

acetyl-IEFD-7-amido-4-methylcoumarin

show

0.37 - 2.7

acetyl-IEPD-7-amido-4-methylcoumarin

show

0.25

acetyl-IETD-4-methylcoumarin-7-amide

Rattus norvegicus

wild-type

6.16 - 7.38

acetyl-IETD-p-nitroanilide

show

1.18 - 1.8

acetyl-IKPD-7-amido-4-methylcoumarin

show

0.6

acetyl-LEFD-7-amido-4-methylcoumarin

Rattus norvegicus

wild-type

1.1

acetyl-LEPD-7-amido-4-methylcoumarin

Rattus norvegicus

wild-type

0.082 - 0.683

Boc-Ala-Ala-Asp-SBzl

show

0.027 - 0.067

IEPD-p-nitroanilide

show

0.082 - 0.117

LEED-p-nitroanilide

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0.5

Nalpha-tert-butyloxycarbonyl-Ala-Ala-Asp thiobenzyl ester

-

mouse

0.55

Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester

-

mouse

0.088 - 0.17

VEID-p-nitroanilide

show

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Release 2023.1 (January 2023)