Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.21.79: granzyme B

This is an abbreviated version!
For detailed information about granzyme B, go to the full flat file.

Word Map on EC 3.4.21.79

Reaction

preferential cleavage: -Asp-/- >> -Asn-/- > -Met-/-, -Ser-/- =

Synonyms

Asp-ase, C11, CCP1, CCPII, CTLA1, CTSGL1, Cytotoxic cell proteinase-1, cytotoxic lymphocyte-associated protease, cytotoxic lymphocyte-specific protein, cytotoxic serine protease granzyme B, cytotoxic T-lymphocyte-associated gene transcript-1, gB, Gra-b, granzyme B, Granzyme G, Granzyme H, GrB, GrzmB, GzB, Gzm, Gzm B, GzmB, GzmB-like enzyme, GzmH, HLp, Human lymphocyte protein, Lymphocyte protease, natural killer cell protease 1, pro-apoptotic serine protease, proGrB, Proteinase, CCP1, rat grB[N66Q], SECT, T-cell serine protease 1-3E

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.79 granzyme B

Inhibitors

Inhibitors on EC 3.4.21.79 - granzyme B

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S,5S)-4-oxo-5-[[N-(phenylacetyl)-L-isoleucyl]amino]-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
(2S,5S)-5-[(N-acetyl-L-isoleucyl)amino]-4-oxo-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
(2S,5S)-5-[[N-(1-benzothiophen-3-ylacetyl)-L-isoleucyl]amino]-4-oxo-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
(2S,5S)-N-((1H-1,2,3-triazol-4-yl)methyl)-5-((3S,4S)-3-(2-(benzo[b]thiophen-3-yl)acetamido)-4-methyl-2-oxohexylamino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
specific granzyme B inhibitor
(3R)-N-cyclopropyl-1-(3-[[(3-methoxyphenyl)sulfonyl]amino]benzoyl)piperidine-3-carboxamide
-
(3S)-N-cycloheptyl-3-methyl-1-oxo-2-(pyridin-2-ylmethyl)-10-(1H-pyrrol-1-yl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide
-
(5R)-4-(3-methoxybenzyl)-10-methyl-N-(3-methylbutyl)-3-oxo-3,4,5,5a,10,10a-hexahydro-2H-[1,4]thiazepino[7,6-b]indole-5-carboxamide
-
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid
100 kDa assembly protein (Ad5-100K)
-
no inhibition is seen in mouse or rat
-
100K assembly protein of human adenovirus type 5
-
potent and specific inhibitor
-
2-[(4E)-4-[3-methoxy-4-(prop-2-yn-1-yloxy)benzylidene]-2,5-dioxoimidazolidin-1-yl]-N-(4-methylphenyl)acetamide
-
2-[(5E)-5-[4-(2-amino-2-oxoethoxy)-3-methoxybenzylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide
-
3-(4-chlorophenyl)-2-([[5-(2,3-dihydro-1,4-benzodioxin-2-yl)-4-phenyl-4,5-dihydro-3H-1,2,4-triazol-3-yl]sulfanyl]methyl)quinazolin-4(3H)-one
-
5-[2-(4-chlorophenoxy)ethoxy]-1-cyclohexyl-1H-tetrazole
-
Ac-IETD-CHO
reduces activity about 6fold
Ac-Ile-Glu-Thr-Asp-CHO
acetyl-Ile-Ile-Glu-Pro-Asp-aldehyde
granzyme B-specific inhibitor
adenovirus 100K assembly protein
-
inhibits gzmB, gzmH relieves gzmB inhibition
-
antipain
benzamidine
benzyloxycarbonyl-Ala-Ala-Asp-chloromethylketone
-
GrB-specific inhibitor. Addition completely blocks reaction with interleukin proIL-18
Bio-x-IEPDp-(Oph)2
-
specific and irreversible inhibition both in vitro and in cells
Boc-Ile-Glu-Ala-Asp-CONH(CH2)2-Ph
Bovine aprotinin
-
chymostatin
cytokine response modifier A (CrmA) of poxyvirus
-
virally encoded serpin
-
ecotin[81-84IEPD]
-
-
engineered chimeric human antichymotrypsin
engineering of a extracellular GrB serpin: a chimeric protein is generated in which the reactive center loop (RCL) of human extracellular antichymotrypsin (ACT) is replaced with that of serpina3n, a mouse extracellular inhibitor of GrB lacking in humans. This serpin contains 27 amino acid residues from the serpina3n RCL and the remaining 395 residues from human ACT. The insertion converts human ACT into a GrB-inhibitory serpin. Several critical residues are identified by scanning mutagenesis on the chimera and serpina3n. Targeted mutagenesis is conducted on wild-type human ACT by specifically substituting those critical residues, creating an inhibitor that contains 99.3% human ACT sequence with only three point mutations. Inhibition kinetics
-
guanidinium hydrochloride
Human plasma alpha1-protease inhibitor
-
Human plasma alpha2-protease macroglobulin
-
hydroxy(6-[2-methoxy-4-[(E)-(3-[2-[(4-methylphenyl)amino]-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyridin-3-yl)oxoammonium
-
IEPD-CHO
a tetrapeptide aldehyde inhibitor, binding structure analysis from crystal structure, PDB ID 1IAU
IETD-CHO
reduces activity about 6fold
interleukin-10
-
granzyme B release from both alloreactive cytotoxic T cell clones and an Epstein-Barr virus-specific cytotoxic T cell clone is inhibited in the presence of interleukin-10 serum
-
interleukin-4
-
significantly suppresses granzyme B synthesis. Interleukin-4-mediated suppression of granzyme B leads to impaired cytotoxicity of adaptive regulatory T cells against K562 target cells
-
L4-100k assembly protein
-
acts as a sink that binds to and inhibits granzyme B, preventing target cell death
-
Lima-bean trypsin inhibitor
-
N-acetyl-L-isoleucyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-prolinamide
-
N-benzyloxycarbonyl-Ile-Glu(-O-methyl)-Thr-Asp(-O-methyl)-fluoromethylketone
i.e. Z-IETD-FMK, specifically and effectively blocks the activity of cattle granzyme B and inhibits the killing of target cells by bovine CD8+ T cells
Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Asp-CH2Cl
phosphoramidon
PI-9
-
granzyme B forms a specific SDS-stable complex with its cognate inhibitor, PI-9
-
protease inhibitor-9
-
endogenous human inhibitor
-
proteinase inhibitor 9 (PI-9)
-
-
-
serine protease inhibitor 6 (Spi6)
-
-
-
serine protease inhibitor A3N
i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB, and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS
-
serpin inhibitor PI-9
-
granzyme B specific serpin inhibitor, complexation of enzyme with inhibitor prevents recognition by receptor importin beta and eliminates requirement of importin alpha for nuclear import
-
serpin proteinase inhibitor 9
-
-
-
serpina3n
-
Soybean trypsin inhibitor
-
z-AAD-chloromethylketone
-
-
Z-Ala-Ala-Asp-CH2Cl
-
-
additional information
-