3.4.21.79: granzyme B
This is an abbreviated version!
For detailed information about granzyme B, go to the full flat file.
Word Map on EC 3.4.21.79
-
3.4.21.79
-
perforin
-
t-cells
-
cd8
-
cytolytic
-
immunotherapy
-
vaccine
-
lymphoma
-
rejection
-
tnf
-
dendritic
-
cell-mediated
-
ifn-gamma
-
allograft
-
tregs
-
tia-1
-
fasl
-
foxp3
-
autologous
-
interferon-gamma
-
caspases
-
degranulation
-
allogeneic
-
epstein-barr
-
antigen-specific
-
virus-specific
-
immunophenotype
-
ctla-4
-
anti-cd3
-
tumor-infiltrating
-
nk-cell
-
extranodal
-
elispot
-
synthesis
-
eomes
-
graft-versus-leukemia
-
cd45ro
-
alcls
-
biotechnology
-
death-1
-
analysis
-
intragraft
-
lag-3
-
hiv-specific
-
medicine
-
diagnostics
-
degradation
-
alloreactive
-
lymphocyte-mediated
-
lymphokine-activated
-
crma
-
b-mediated
-
pharmacology
-
ag-specific
-
banff
-
hepatosplenic
-
anti-pd-1
-
interleukin-15
- 3.4.21.79
- perforin
- t-cells
- cd8
-
cytolytic
-
immunotherapy
- vaccine
- lymphoma
-
rejection
- tnf
- dendritic
-
cell-mediated
- ifn-gamma
-
allograft
-
tregs
- tia-1
- fasl
- foxp3
-
autologous
- interferon-gamma
-
caspases
-
degranulation
-
allogeneic
-
epstein-barr
-
antigen-specific
-
virus-specific
-
immunophenotype
-
ctla-4
-
anti-cd3
-
tumor-infiltrating
-
nk-cell
-
extranodal
-
elispot
- synthesis
-
eomes
-
graft-versus-leukemia
-
cd45ro
-
alcls
- biotechnology
-
death-1
- analysis
-
intragraft
- lag-3
-
hiv-specific
- medicine
- diagnostics
- degradation
-
alloreactive
-
lymphocyte-mediated
-
lymphokine-activated
- crma
-
b-mediated
- pharmacology
-
ag-specific
-
banff
-
hepatosplenic
-
anti-pd-1
- interleukin-15
Reaction
preferential cleavage: -Asp-/- >> -Asn-/- > -Met-/-, -Ser-/- =
Synonyms
Asp-ase, C11, CCP1, CCPII, CTLA1, CTSGL1, Cytotoxic cell proteinase-1, cytotoxic lymphocyte-associated protease, cytotoxic lymphocyte-specific protein, cytotoxic serine protease granzyme B, cytotoxic T-lymphocyte-associated gene transcript-1, gB, Gra-b, granzyme B, Granzyme G, Granzyme H, GrB, GrzmB, GzB, Gzm, Gzm B, GzmB, GzmB-like enzyme, GzmH, HLp, Human lymphocyte protein, Lymphocyte protease, natural killer cell protease 1, pro-apoptotic serine protease, proGrB, Proteinase, CCP1, rat grB[N66Q], SECT, T-cell serine protease 1-3E
ECTree
Advanced search results
Inhibitors
Inhibitors on EC 3.4.21.79 - granzyme B
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
(2S,5S)-4-oxo-5-[[N-(phenylacetyl)-L-isoleucyl]amino]-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
(2S,5S)-5-[(N-acetyl-L-isoleucyl)amino]-4-oxo-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
(2S,5S)-5-[[N-(1-benzothiophen-3-ylacetyl)-L-isoleucyl]amino]-4-oxo-N-(1H-1,2,3-triazol-4-ylmethyl)-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
(2S,5S)-N-((1H-1,2,3-triazol-4-yl)methyl)-5-((3S,4S)-3-(2-(benzo[b]thiophen-3-yl)acetamido)-4-methyl-2-oxohexylamino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide
-
specific granzyme B inhibitor
(3R)-N-cyclopropyl-1-(3-[[(3-methoxyphenyl)sulfonyl]amino]benzoyl)piperidine-3-carboxamide
-
(3S)-N-cycloheptyl-3-methyl-1-oxo-2-(pyridin-2-ylmethyl)-10-(1H-pyrrol-1-yl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide
-
(5R)-4-(3-methoxybenzyl)-10-methyl-N-(3-methylbutyl)-3-oxo-3,4,5,5a,10,10a-hexahydro-2H-[1,4]thiazepino[7,6-b]indole-5-carboxamide
-
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid
100K assembly protein of human adenovirus type 5
-
potent and specific inhibitor
-
2-[(4E)-4-[3-methoxy-4-(prop-2-yn-1-yloxy)benzylidene]-2,5-dioxoimidazolidin-1-yl]-N-(4-methylphenyl)acetamide
-
2-[(5E)-5-[4-(2-amino-2-oxoethoxy)-3-methoxybenzylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide
-
3-(4-chlorophenyl)-2-([[5-(2,3-dihydro-1,4-benzodioxin-2-yl)-4-phenyl-4,5-dihydro-3H-1,2,4-triazol-3-yl]sulfanyl]methyl)quinazolin-4(3H)-one
-
adenovirus 100K assembly protein
-
inhibits gzmB, gzmH relieves gzmB inhibition
-
benzyloxycarbonyl-Ala-Ala-Asp-chloromethylketone
-
GrB-specific inhibitor. Addition completely blocks reaction with interleukin proIL-18
Bio-x-IEPDp-(Oph)2
-
specific and irreversible inhibition both in vitro and in cells
engineered chimeric human antichymotrypsin
engineering of a extracellular GrB serpin: a chimeric protein is generated in which the reactive center loop (RCL) of human extracellular antichymotrypsin (ACT) is replaced with that of serpina3n, a mouse extracellular inhibitor of GrB lacking in humans. This serpin contains 27 amino acid residues from the serpina3n RCL and the remaining 395 residues from human ACT. The insertion converts human ACT into a GrB-inhibitory serpin. Several critical residues are identified by scanning mutagenesis on the chimera and serpina3n. Targeted mutagenesis is conducted on wild-type human ACT by specifically substituting those critical residues, creating an inhibitor that contains 99.3% human ACT sequence with only three point mutations. Inhibition kinetics
-
hydroxy(6-[2-methoxy-4-[(E)-(3-[2-[(4-methylphenyl)amino]-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyridin-3-yl)oxoammonium
-
IEPD-CHO
a tetrapeptide aldehyde inhibitor, binding structure analysis from crystal structure, PDB ID 1IAU
interleukin-10
-
granzyme B release from both alloreactive cytotoxic T cell clones and an Epstein-Barr virus-specific cytotoxic T cell clone is inhibited in the presence of interleukin-10 serum
-
interleukin-4
-
significantly suppresses granzyme B synthesis. Interleukin-4-mediated suppression of granzyme B leads to impaired cytotoxicity of adaptive regulatory T cells against K562 target cells
-
L4-100k assembly protein
-
acts as a sink that binds to and inhibits granzyme B, preventing target cell death
-
N-acetyl-L-isoleucyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-prolinamide
-
N-benzyloxycarbonyl-Ile-Glu(-O-methyl)-Thr-Asp(-O-methyl)-fluoromethylketone
i.e. Z-IETD-FMK, specifically and effectively blocks the activity of cattle granzyme B and inhibits the killing of target cells by bovine CD8+ T cells
PI-9
-
granzyme B forms a specific SDS-stable complex with its cognate inhibitor, PI-9
-
serine protease inhibitor A3N
i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB, and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS
-
serpin inhibitor PI-9
-
granzyme B specific serpin inhibitor, complexation of enzyme with inhibitor prevents recognition by receptor importin beta and eliminates requirement of importin alpha for nuclear import
-
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid
-
-
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid
-
GzmB inhibitor
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid
-
peptide-mimetic analog of IEPD-aldehyde
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid
-
peptide-mimetic analog of IEPD-aldehyde
-
inhibitor for human and mouse GrB, expressed by Sertoli cells. Inhibitor shares homology with human alpha-1-anti-chymotrypsin
-
serpina3n
-
inhibitor for human and mouse GrB, expressed by Sertoli cells. Inhibitor shares homology with human alpha-1-anti-chymotrypsin
-
no inhibition by benzyloxycarbonyl-Val-Ala-Asp-(O-methyl)-fluoromethylketone
-
additional information
-
no inhibition by benzyloxycarbonyl-Val-Ala-Asp-(O-methyl)-fluoromethylketone
-
additional information
-
zVAD-fmk completely inhibits GzmB induced executioner caspase activity
-
additional information
-
treatment of T1 cells with pifithrin-alpha results in inhibition of p53 phosphorylation and in a significant decrease in GrB-induced apoptotic T1 cell death. siRNA targeting p53 induces inhibition of streptolysin-O/GrB-mediated apoptotic T1 cell death
-
additional information
-
inhibition of caspases does not clonogenically rescue cells from human GzmB
-
additional information
-
natural killer cells stimulated in vitro with interleukin-2 reduce their granzyme H levels over 3-4 days
-
additional information
-
no significant difference of granzyme B between patients without immunologic treatment and patients after introduction of immunologic treatment, this may be attributed to the variety of clinical stage at the introduction of immunologic treatment and the variety of immunologic treatment
-
additional information
-
back salt progressively inhibits granzyme B-mediated von Willebrand factor cleavage
-
additional information
-
induced hypoacetylation in GZMB gene loci by a HAT inhibitor (curcumin) results in decreased expressions of GZMB in memory cells in response to in vitro stimulation
-
additional information
structure-based design of non-covalent small molecule inhibitors for human granzyme B via virtual screening strategy employing three constraints and probe sitemapping with FTMAP, usage of crystal structure PDB ID 1FQ3
-
additional information
-
structure-based design of non-covalent small molecule inhibitors for human granzyme B via virtual screening strategy employing three constraints and probe sitemapping with FTMAP, usage of crystal structure PDB ID 1FQ3
-
additional information
-
no inhibition with 100K assembly protein of human adenovirus type 5
-
additional information
-
inhibition of caspases may clonogenically rescue cells from mouse GzmB
-
additional information
-
to protect beta cells from allogeneic CTL attack, one needs to inhibit the perforin/granzyme and probably also the TNFalpha pathway. Granzyme B-dependent death of NIT-1 cells is not inhibited by Bcl-2 overexpression
-
additional information
-
no inhibition with 100K assembly protein of human adenovirus type 5
-