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Literature summary for 3.4.21.79 extracted from
- Dissociated production of perforin, granzyme B, and IFN-gamma by HIV-specific CD8(+) cells in HIV infection (2008), AIDS Res. Hum. Retroviruses, 24, 62-71.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | CMV/EBV/influenza peptide pool peptides do not induce GzB release in CD8+ cells from healthy donors within 24 h. Purified CD8+ cells after CMV/EBV/influenza peptide pool peptide stimulation show induction of GzB after 72 h in vitro. HIV peptides induce GzB secretion in HIV-infected individuals directly ex vivo | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | extension of the present standard of IFN-gamma measurements to the analysis of GzB and perforin release in functional T cell assays will provide new insights into CD8+ effector T cell function in HIV infection | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
HIV-positive patients and healthy controls | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| additional information | CD8+ T cell | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GzB | - |
Homo sapiens |
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