Literature summary for 3.4.21.79 extracted from

Besenicar, M.P.; Metkar, S.; Wang, B.; Froelich, C.J.; Anderluh, G.
Granzyme B translocates across the lipid membrane only in the presence of lytic agents (2008), Biochem. Biophys. Res. Commun., 371, 391-394.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	in the presence of perforin, modest cleavage of the encapsulated PEG-P at large unilamellar vesicles/perforin molar ratio of 1000 at acidic and neutral pH. Granzyme B requires a translocation agent to enter the target cell. Granzyme B readily accesses PEG-P only when a membrane disrupting agent, e.g. TX-100, streptolysin O or perforin, is present	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	granzyme B does not bind membrane phospholipids nor has intrinsic membranolytic properties	Homo sapiens	?	-	?
PEG-P + H2O	virtually all soluble PEG-P is cleaved in 3 min, suggesting PEG-P is a sensitive indicator of granzyme B activity. The granzyme can not access PEG-P when encapsulated in 1,2-dioleoyl-sn-glycero-3-phosphocholine large unilamellar vesicles	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
GrB	-	Homo sapiens

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Release 2023.1 (January 2023)