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3.4.21.79: granzyme B

This is an abbreviated version!
For detailed information about granzyme B, go to the full flat file.

Word Map on EC 3.4.21.79

Reaction

preferential cleavage: -Asp-/- >> -Asn-/- > -Met-/-, -Ser-/- =

Synonyms

Asp-ase, C11, CCP1, CCPII, CTLA1, CTSGL1, Cytotoxic cell proteinase-1, cytotoxic lymphocyte-associated protease, cytotoxic lymphocyte-specific protein, cytotoxic serine protease granzyme B, cytotoxic T-lymphocyte-associated gene transcript-1, gB, Gra-b, granzyme B, Granzyme G, Granzyme H, GrB, GrzmB, GzB, Gzm, Gzm B, GzmB, GzmB-like enzyme, GzmH, HLp, Human lymphocyte protein, Lymphocyte protease, natural killer cell protease 1, pro-apoptotic serine protease, proGrB, Proteinase, CCP1, rat grB[N66Q], SECT, T-cell serine protease 1-3E

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.79 granzyme B

Source Tissue

Source Tissue on EC 3.4.21.79 - granzyme B

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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type II
Manually annotated by BRENDA team
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Epstein-Barr virus-transformed autologous B lymphoblastoid cell line
Manually annotated by BRENDA team
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IL-21 and GzmB serum levels are highly correlated in subjects with systemic lupus erythematosus and freshly isolated CD51 systemic lupus erythematosus B cells constitutively express GzmB
Manually annotated by BRENDA team
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GrB is expressed in 7 out of 12 bladder cancer cell lines
Manually annotated by BRENDA team
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in stroke samples, Gra-b co-localizes with Annexin-V+/TUNEL+ in degenerating neurons
Manually annotated by BRENDA team
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between smooth muscle cells
Manually annotated by BRENDA team
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transcripts of the granzyme G gene are detected at the 2-cell stage, but are absent at the oocyte, 1-cell, 96 hr, and later stages. Spatial expression is confined to the extra-embryonic trophoblasts during the middle implantation stage of the mouse placenta
Manually annotated by BRENDA team
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in medullary carcinoma of the breast (MCB), GrB-expressing cytotoxic T cells are found in large numbers, often nearby apoptotic tumor cells
Manually annotated by BRENDA team
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septic megakaryocytes produce platelets with acutely altered mRNA profiles, and these platelets mediate lymphotoxicity via granzyme B
Manually annotated by BRENDA team
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perforin-independent expression
Manually annotated by BRENDA team
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elevated expression of granzyme B
Manually annotated by BRENDA team
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regulatory T cells (Tregs) freshly isolated from the peripheral blood of normal adults lack granzyme B expression. Tregs subjected to prolonged TCR and CD28 triggering, in the presence of IL-2, express high levels of granzyme B but CD3 stimulation alone or IL-2 treatment alone fail to induce granzyme B. Treatment of Tregs with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin or the PI3 kinase (PI3K) inhibitor LY294002 markedly suppressed granzyme B expression
Manually annotated by BRENDA team
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expressed in the synovial fluid of rheumatoid arthritis patients
Manually annotated by BRENDA team
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levels of GrB in the serum and synovial fluid of rheumatoid arthritis patients is strikingly associated with the severity of erosive joint disease
Manually annotated by BRENDA team
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perforin-independent expression
Manually annotated by BRENDA team
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around small vessels
Manually annotated by BRENDA team
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GrB is expressed, in absence of perforin in urothelial carcinoma cells. Significant differences are found between GrB expression and both increasing pathological tumor spreading and high-grade vs. low-grade pTa tumors
Manually annotated by BRENDA team
additional information