Literature summary for 3.4.21.79 extracted from

Araki, Y.; Fann, M.; Wersto, R.; Weng, N.P.
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B) (2008), J. Immunol., 180, 8102-8108.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	in vitro stimulation increases the mRNA levels of GZMB in both naive and memory cells. Activation-induced GZMB expression increases significantly faster and higher in memory cells than in naive cells for the first 24-32 h. At 72 h after stimulation, naive cells express higher levels of GZMB than do memory cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	induced hypoacetylation in GZMB gene loci by a HAT inhibitor (curcumin) results in decreased expressions of GZMB in memory cells in response to in vitro stimulation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	low levels of GZMB mRNA and no detectable levels of granzyme B protein in resting naive or memory CD8 T cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GzmB	-	Homo sapiens

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Release 2023.1 (January 2023)