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3.4.21.46: complement factor D

This is an abbreviated version!
For detailed information about complement factor D, go to the full flat file.

Word Map on EC 3.4.21.46

Reaction

selective cleavage of Arg-/-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor =

Synonyms

28 kDa protein, adipocyte, Adipsin, alternative complement pathway component Factor D, C3 convertase activator, C3 proactivator convertase, CFD, complement factor D/adipsin and kallikrein-like serine protease, convertase, C3 proactivator, Df, Df protein, endogenous vascular elastase, esterase, properdin factor D, factor D, factor D (complement), fD, PDGF-D, platelet-derived growth factor D, PoDAK, vascular endothelial growth factor, vascular endothelial growth factor D, VEGF-D

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.46 complement factor D

Substrates Products

Substrates Products on EC 3.4.21.46 - complement factor D

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ac-Lys-Arg-4-nitroanilide + H2O
Ac-Lys-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-Gly-L-Lys methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
Benzoyl-L-Arg methyl ester + H2O
Benzoyl-L-Arg + methanol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Arg-benzyl thioester + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-Lys-thiobenzyl ester + H2O
benzyloxycarbonyl-L-Lys + thiobenzoate
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Lys thiobenzyl ester + H2O
benzyloxycarbonyl-Lys + phenylmethanethiol
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Lys-Arg-isobutyl thioester + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Lys-thiobenzylester + H2O
?
show the reaction diagram
-
-
-
?
complement component C3bB + H2O
?
show the reaction diagram
complement factor B + H2O
?
show the reaction diagram
complement factor B + H2O
Bb fragment + Ba fragment
show the reaction diagram
complement factor B + H2O
fragment Ba + fragment Bb
show the reaction diagram
factor B + H2O
Ba + Bb
show the reaction diagram
-
-
smaller and larger cleavage subunit of factor B, respectively
-
?
factor B + H2O
Bb fragment + Ba fragment
show the reaction diagram
N-Acetyl-L-Tyr ethyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzoyl-Ile-Glu-Gly-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-acetyl-L-Arg methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-acetyl-L-Lys methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-Benzoyl-L-Arg ethyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-tosyl-L-Lys methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
Nepsilon-carbobenzoxy-L-Lys methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
p-tosyl-L-Arg methyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
pro-convertase C3bB + H2O
active C3 convertase C3bBb + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-