3.4.21.46: complement factor D

This is an abbreviated version!
For detailed information about complement factor D, go to the full flat file.

Word Map on EC 3.4.21.46

3.4.21.46

angiogenesis

angiogenic

vessel

metastasis

neovascularization

hypoxia

artery

hypoxia-inducible

necrosis

retinal

antiangiogenic

umbilical

bevacizumab

microvessels

vein

capillary

factor-1

huvecs

vegfr-2

collagen

vasculature

retinopathy

eyes

ovarian

macular

tumour

tube

microvascular

mesenchymal

anti-vegf

lymphatic

receptor-2

pro-angiogenic

bfgf

intravitreal

progression-free

edema

choroid

metalloproteinase

endothelium

hypertension

sprout

matrigel

paracrine

lymph

hif-1alpha

mmp-9

sunitinib

drug development

sorafenib

vitreous

medicine

Reaction

selective cleavage of Arg-/-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor =

Synonyms

28 kDa protein, adipocyte, Adipsin, alternative complement pathway component Factor D, C3 convertase activator, C3 proactivator convertase, CFD, complement factor D/adipsin and kallikrein-like serine protease, convertase, C3 proactivator, Df, Df protein, endogenous vascular elastase, esterase, properdin factor D, factor D, factor D (complement), fD, PDGF-D, platelet-derived growth factor D, PoDAK, vascular endothelial growth factor, vascular endothelial growth factor D, VEGF-D

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.46 complement factor D

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Results	in table
4	Activating Compound
169	AA Sequence
8	Application
1	CAS Registry Number
14	Cloned(Commentary)
11	Crystallization (Commentary)
77827	Disease/ Diagnostics
9	Expression
21	General Information
1	General Stability
41	IC50 Value
53	Inhibitors
8	KM Value [mM]
3	Localization
1	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
189	Organism
103	PDB ID
3	pI Value
4	Posttranslational Modification
28	Protein Variants
18	Purification (Commentary)
1	Reaction
1	Reaction Type
50	Reference
77	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
41	Substrates and Products (Substrate)
7	Subunits
49	Synonyms
8	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.46 - complement factor D

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0.084

(1R,2S)-2-([4-[3-(aminomethyl)anilino]quinazolin-2-yl]amino)cyclohexane-1-carboxylic acid

Homo sapiens

at pH 7.5 and 25°C

0.000012

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(2-fluoro-3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.000023

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(2-fluoro-3-trifluoromethylphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.00015

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-chlorophenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.00015

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-difluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.00032

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-methoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.00005

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.000045

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-[(3-bromophenyl)amide] 2-[(1-carbamoyl-1H-indol-3-yl)amide]

Homo sapiens

at pH 7.5 and 25°C

0.000006

(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-[(6-bromo-pyridin-2-yl)-amide] 2-[(1-carbamoyl-1H-indol-3-yl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.000014

(1R,3S,5R)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(6-trifluoromethyl-pyridin-2-yl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.00065

(1S,2S,5R)-3-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.044

(2S)-2-([4-[3-(aminomethyl)anilino]pyrimidin-2-yl]amino)-3-methylbutanoic acid

Homo sapiens

at pH 7.5 and 25°C

0.075

(2S)-2-([4-[3-(aminomethyl)anilino]quinazolin-2-yl]amino)-3-methylbutanoic acid

Homo sapiens

at pH 7.5 and 25°C

0.0058

(2S)-N2-(diphenylmethyl)-N1-(1-methyl-1H-indol-3-yl)pyrrolidine-1,2-dicarboxamide

Homo sapiens

at pH 7.5 and 25°C

0.00005

(2S,4R)-4-fluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.00085

(2S,4R)-4-methyl-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.0005

(2S,4S)-4-amino-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.0007

(2S,4S)-4-fluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.0014

(2S,4S)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.0003

(2S,4S)-4-methyl-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide

Homo sapiens

at pH 7.5 and 25°C

0.03

(R)-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.00045

(S)-4,4-difluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.022

(S)-piperidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.0005

(S)-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.02

(S)-pyrrolidine-1,2-dicarboxylic acid 1-[(1-methyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxyphenyl)-amide]

Homo sapiens

at pH 7.5 and 25°C

0.000006

1-(2-[(1R,3S,5R)-3-[(6-bromopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl)-1H-indazole-3-carboxamide

Homo sapiens

at pH 7.5 and 25°C

0.000017

1-[2-[(1R,3S,5R)-3-[[(1R)-1-(3-chloro-2-fluorophenyl)ethyl]carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Homo sapiens

at pH 7.5 and 25°C

0.0034

3'-(aminomethyl)-5-(3-methylbutanamido)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)[1,1'-biphenyl]-3-carboxamide (incorrect configuration definition!)

Homo sapiens

at pH 7.5 and 25°C

0.31

3'-(aminomethyl)-N-benzyl[1,1'-biphenyl]-3-carboxamide

Homo sapiens

at pH 7.5 and 25°C

0.098

3'-(aminomethyl)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl][1,1'-biphenyl]-3-carboxamide

Homo sapiens

at pH 7.5 and 25°C

0.037 - 0.054

3'-(aminomethyl)-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl][1,1'-biphenyl]-3-carboxamide

show

0.02

3-([3-[3-(aminomethyl)anilino]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino)phenol

Homo sapiens

at pH 7.5 and 25°C

0.014

methyl 2-([[(2S)-2-[[3-(trifluoromethoxy)phenyl]carbamoyl]pyrrolidine-1-carbonyl]amino]methyl)benzoate

show

0.043

N-[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]-2-phenylacetamide

Homo sapiens

at pH 7.5 and 25°C

0.12

N-[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]-3-methylbutanamide

Homo sapiens

at pH 7.5 and 25°C

0.14

N-[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]-3-phenylpropanamide

Homo sapiens

at pH 7.5 and 25°C

0.69

N-[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]acetamide

Homo sapiens

at pH 7.5 and 25°C

0.257

N-[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]benzamide

Homo sapiens

at pH 7.5 and 25°C

0.000012

[2-([3'-[(1S)-1-amino-2-hydroxyethyl][1,1'-biphenyl]-3-yl]methoxy)phenyl]acetic acid

Homo sapiens

pH and temperature not specified in the publication

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Release 2023.1 (January 2023)